Abstract: An absorbable prophylactic composition for protecting against ionizing or nonionizing electromagnetic waves. The composition is derived from a crude extract of residual fractions of crushed grapes, and primarily from solid material comprising pips, stalks and skins of grapes and/or combinations thereof. The crude extract is obtained by first pulverizing the fraction or fractions from the grapes to form a powder, and then subjecting the powder to at least two extraction processes, one with acetone and the other with ethyl acetate. The extract is then ingested in doses between about 20 mg to 3 g for an adult male. Tests have demonstrated the efficacy of this composition against changes induced by ionizing radiation (x-rays) and nonionizing radiation (UV-C).

Abstract: A high speed agitation granulator method of preparing a substantially spherical granule for pharmaceutical use comprising a medicament for pharmaceutical use, wherein the medicament has an aqueous solubility of 0.01 to 0.30 g/ml, which method comprises introducing a mixture of medicament and excipients comprising at least 5% crystalline cellulose into the granulator and spraying on water or a mixture of ethanol and water as binder solution; a substantially spherical granule for pharmaceutical use comprising famciclovir and 5% or more crystalline cellulose, together with an optional coating; and a sachet containing a unit dose of famciclovir in the form of such granules.

Abstract: Three-dimensional silicone elastomers having polyether and higher alkyl functionality in their molecules form networks of crosslinked linear siloxanes with polyether and olefin containing repeating units, and these silicone elastomers can be used as emulsifiers for making O/O and three-phase aqueous emulsions. One of the oil phases is a silicone oil, while the other oil phase is an organic oil such as mineral oil or castor oil. These emulsions of two and three mutually insoluble liquids are useful in personal and health care applications.

Abstract: A controlled release analgesic dosage form comprising: a core comprising an analgesic and binding agent; and a coating comprising an enteric polymer, a water insoluble second polymer and a lubricant.

Abstract: The hair cleaning preparation for improving the shine of the hair is an aqueous solution or emulsion which contains water; from 5 to 50 percent by weight of an anionic, nonionic and/or amphoteric surfactant compound; from 2 to 10 percent by weight of a mixture of at least two fruit acids selected from the group consisting of lactic acid, citric acid, maleic acid, tartaric acid, gluconic acid, fumaric acid and succinic acid; from 0.2 to 2 percent by weight of at least one ingredient selected from the group consisting of pantothenol, pantothenic acid and esters of pantothenic acid and at least one cosmetic ingredient selected from the group consisting of perfume oils, preservatives and pH buffer substances. This hair cleaning preparation does not contain any oily or greasy ingredients.

Abstract: The invention relates to a cosmetic or pharmaceutical composition containing a moisturizing effective amount of S water, as well as a method for enhancing the moisturization capacity of a skin care composition containing an aqueous component comprising incorporating S water as all or part of the aqueous component

Abstract: Hard shelled capsules and dry, powdered pharmaceutical formulations are treated with supercritical fluids to remove impurities such as mold lubricants and moisture.

Abstract: Cosmetic/pharmaceutical compositions, well suited for the treatment of unwanted skin wrinkles, e.g., for visibly reducing human skin wrinkles, comprise an effective antiwrinkle amount of at least one extract of at least one member of the Iridaceae family that relaxes and/or loosens cutaneous and/or subcutaneous tissue, formulated into a cosmetically/pharmaceutically acceptable excipient or carrier therefor.

Abstract: The dye precursor-containing composition for hair dyeing contains at least one p-aminophenol derivative compound of the formula (I): in which R1 and R2 each can be H, an alkyl, a hydroxyalkyl, an aminoalkyl, a mono- or dialkylaminoalkyl, an acylaminoalkyl, an aryl- or alkylsulfonylaminoalkyl, a carbamidoalkyl, an acyl, an aryl, an alkylsulfonyl or a carbomoyl group, each alkyl group having from 1 to 4 carbon atoms, or R1 and R2 together are part of a heterocyclic, non-aromatic 5- or 6-membered ring, with or without an oxo group; at least one 5-amino-2-methylphenol derivative compound of the formula (II), in which R is H, a C1- to C4-alkyl, a C2- to C4-hydroxyalkyl group or a C2- to C4- polyhydroxyalkyl group; and at least one m-phenylenediamine derivative compound of the formula (III), in which R1 and R2 each can be H, a C1- to C4-alkyl, a C2- to C4-hydroxyalkyl or a C3- to C4-polyhydroxyalkyl group; R3 stands for H, a C1- to C6-alkyl, a C1- to C4-alkoxy,

Abstract: It is described a new method for the preparation of pharmaceutical tablets carrying poorly soluble in water principle; this method allows to obtain tablets with fast and/or slow release of the active principle. The peculiar feature is the fact that the poorly soluble in water active principle (es: nifedipine) is treated with a surfactant, during the granulation phase or whatever during the preparation process; the obtained product, subjected to a compression, produces pharmaceutical tablets which show high bioavailability of the carried active principle. This procedure can be used to prepare polymeric matrixes (with modified release), formed by tablets with one or more layers. The procedure of manufacture and the characteristics of the new finished tablet are described.

Abstract: Cross-linked particles are provided that are useful for delivery of pharmaceutical agents. The particles comprise at least one polymeric compound and a spacer compound, where the polymeric compound and the spacer each comprise reactive carboxyl, hydrazidyl, amino and/or thiol groups. The particles are cross-linked via covalent linkage of the reactive groups on the polymer and spacer respectively. Compositions comprising pharmaceutical agents contained within the particles are disclosed. Methods for preparing the particles, for encapsulating pharmaceutical agents within the particles, and for using the particles for controlled release of the pharmaceutical agent within the patient also are provided.

Abstract: A process for producing a pharmaceutical powder for inhalation comprising crystalline particles of an inhalation compound, comprising dissolving an inhalation compound in a solvent; and introducing the solution containing the inhalation compound in droplet form or as a jet stream into an anti-solvent which is miscible with the solvent and which is under agitation.

Abstract: The present invention provides a hair treatment composition (I) comprising the following components (a) and (b), or a hair treatment composition (II) comprising the following components (c) and (b), and a method for imparting elasticity to the hair using the composition: (a) an organic solvent; (b) at least one aromatic sulfonic acid selected from naphthalenesulfonic acids, azulenesulfonic acids, tetralin-sulfonic acids, indansulfonic acids and benzophenonesulfonic acids or salts thereof; and (c) a reducing agent.

Abstract: A composition, particularly adapted for oral administration, containing omeprazole, and a method for preparing the composition, are disclosed. The composition, being exempt of alkaline-reacting compounds, contains a core constituted of nuclei and said benzimidazole, the nuclei and benzimidazole being compressed together, an intermediate layer, and an enteric layer.

Abstract: A food formulation comprising an edible alkyl, or substituted alkyl cellulose compound and an edible polyhydric alcohol is provided which in combination and in specified amounts have been found to synergistically attain progressive, controlled hydration thereof during passage through the digestive system. The formulation may be further provided with a time-release coating thereover.

Abstract: An oral dosage form that provides for the controlled release of an analgesic wherein the dosage form comprises a core containing an analgesic that is coated with a mixture of an enteric polymer, a water insoluble polymer and a lubricant.

Abstract: The sustained release tablet of (R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5-ij]-quinolin-2(1H)-one (Z)-2-butenedioate (1:1) which is disclosed permits twice daily administration of (R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5-ij]-quinolin-2(1H)-one (Z)-2-butenedioate (1:1) to treat humans with Parkinson's disease.

Abstract: An oily composition having excellent storability and forming no precipitate of an ingredient selected from the group of gelatin and gum arabic during the storage for a long period of time is provided. This composition is composed of a solid phase comprising an effective substance selected from the group consisting of a water-soluble substance and water-dispersible substance and 50 to 4,000 parts by weight, for 100 parts by weight of the effective substance, of the ingredient, and an oil phase comprising an oily component and an emulsifier, wherein the solid phase in the form of fine particles having an average particle diameter of not larger than 5 &mgr;m is dispersed in the oil phase, the water content of the solid phase is not higher than 30% by weight and the water content of the whole composition is not higher than 20% by weight.

Abstract: The hair treatment composition for increasing the formability and luster of hair contains from 0.01 to 10 percent by weight of a copolymer formed from at least one ethylenic unsaturated monomer of the formula (I): CH2═CR1R2  (I), wherein R1 is A—(CH2CH2O)x—R3 or COOH group and A is C(═O)O, C(═O)NH or CH2O, x is a number from 1 to 100, R3 is a C8- to C30-alkyl group, R2 is H, a C1- to C30-alkyl group or a CH2—R1 group, with the proviso that at least one of the groups, R1 and R2, contain the A—(CH2CH2O)x—R3 group; and from at least one ethylenic unsaturated monomer of the formula (II): CH2═CR4COOR5  (II), wherein R4 and R5 are, independently of each other, H or an alkyl group with 1 to 30 carbon atoms; from 0.01 to 50 percent by weight of a polyethylene glycol with a molecular weight over 500 g/mol and from 0.01 to 20 percent by weight of a nonionic surfactant having an HLB-value under 20.

Abstract: A paraffin refill or package system or article wherein the paraffin mixture is provided in a large total volume which has preselected portions or sub-volumes which are defined by a divider structure. The sub-volumes or portions are preferably cube shaped. In use, a single carton containing the paraffin refill or system is opened. One or more portions or cubes of the system are added to the bath apparatus reservoir and heated. The user then observes the resultant liquefied mix to determine whether additional portions of the system are necessary. Any remaining portions of the system are saved in the carton.