Patents Examined by Brian M. Burn
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Patent number: 5962738Abstract: The present invention relates to an improved method of synthesizing polyamines, the improvement comprising producing polyamines having an increased nitrogen content. It concerns the improved fuel additives thereby produced, and the resultant improved fuel composition which comprises an admixture of said fuel additive and a gasoline.Type: GrantFiled: June 16, 1998Date of Patent: October 5, 1999Assignee: Petrokleen, Ltd.Inventors: Donald E. Koehler, William J. Claffey
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Patent number: 5962741Abstract: The present invention relates to a hydrogenation process for the production of aromatic halogen-amino compounds by means of catalytic hydrogenation on noble metal catalysts of corresponding aromatic halonitro compounds, characterised in that a rhodium, ruthenium, iridium, platinum or palladium catalyst which is modified with an inorganic or organic phosphorus compound with a degree of oxidation of less than V, is used, in the presence of a vanadium compound.Type: GrantFiled: November 14, 1997Date of Patent: October 5, 1999Assignee: Novartis AGInventors: Peter Baumeister, Urs Siegrist, Martin Studer
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Patent number: 5962721Abstract: A method of preparing carbamates by reacting amine with alcohol and mixed gas of CO/O.sub.2 in the presence of one or more catalyst selected from the group consisting of monovalent copper halide having the structural formula of Cu?NCMe.sub.4 !X, K?CuX.sub.2 !, ?CuX(S)! (wherein X=Cl, Br, or I; S=solvent) or monovalent copper compound having carbonyl group having the structural formula of ?Cu(CO)X.sub.a L.sub.b !.sub.m Y.sub.n (wherein, X=CF.sub.3 CO.sub.2, Cl, HB(pz).sub.3 (wherein, pz=pyrazoyl,C.sub.3 H.sub.3 N.sub.2), LBF.sub.2, {LBF.sub.2 =difluoro-3,3'-(trimethylenedinitrilo)bis(2-butanone oximato)borate}; L=en, diene; Y=BPh.sub.4, AsF.sub.6 ; a,b=0,1; m=1-4; n=0,1).Type: GrantFiled: April 29, 1998Date of Patent: October 5, 1999Assignee: Korea Institute of Science and TechnologyInventors: Hoon Sik Kim, Sang Deuk Lee, Hyun-joo Lee, In-Seok Seo, Yong Jin Kim
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Patent number: 5959150Abstract: A process for preparing methylamines is disclosed herein which comprises the step of reacting methanol with ammonia in the presence of a mordenite in which the ratio of the length of mordenite crystals in a c axis direction to that of the mordenite crystals in an a axis direction or a b axis direction, c/a or c/b is 2 or more, whereby the synthetic activity of the methylamines can be maintained at a high level, and the production ratio of trimethylamine can be inhibited to a low level of about several percent to predominantly produce dimethylamine and monomethylamine.Type: GrantFiled: April 21, 1995Date of Patent: September 28, 1999Assignee: Mitsui Chemicals, Inc.Inventors: Tadamitsu Kiyoura, Shigeki Nakahara
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Patent number: 5959145Abstract: Novel oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.Type: GrantFiled: July 15, 1993Date of Patent: September 28, 1999Assignee: Washington UniversityInventors: Robert O. Heuckeroth, Steven P. Adams, Jeffrey I. Gordon
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Patent number: 5959149Abstract: A method for the purification of dinitroanilines having herbicidal activity by means of the known reactions of denitrosation using acid, and denitration in a neutral or basic environment in the presence of a phase-transfer catalyst, wherein:the denitrosation reaction is effected on the dinitration mixture containing the dinitroaniline of interest and the corresponding unwanted N-nitroso- and N-dinitroaniline impurities, and in the absence of solvent,the denitration reaction is conducted sequentially to the denitrosation reaction in the same reactor with the addition to the denitrosation product as such of an aqueous base, and of the said phase-transfer catalyst.Type: GrantFiled: July 10, 1998Date of Patent: September 28, 1999Assignee: Finchimica S.p.A.Inventor: Gianluca Bernardi
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Patent number: 5958836Abstract: The present invention relates to a method for the prevention of growth of algae by incorporating within liquids or coating on surfaces certain substituted amino alcohols. More precisely, this invention provides for algistat end uses for amino alcohol compounds endowed with chain extension which have the general formula: ##STR1## wherein n is 1-1000; and R.sub.1 =R.sub.2, and R.sub.1 and R.sub.2 are from the croup consisting of --CH.sub.2 --CH.sub.2 --; --CH.sub.2 --C(CH.sub.3)H--; and --C(CH.sub.3)H--CH.sub.2 --; R.sub.3, and R.sub.4 are each independently selected from the group consisting of H, --CH.sub.3, --CH.sub.2 CH.sub.3, --CH.sub.2 OH, and --CH.sub.2 --CH.sub.2 --OH; and the diasteromeric salts thereof.Type: GrantFiled: September 26, 1998Date of Patent: September 28, 1999Assignee: TriQuest, LPInventors: Elmer Rauckman, Michael T. Sheehan, William W. Wilkison
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Patent number: 5955634Abstract: A process and reagent for allylating a nucleophile preferably of formula (V).(R).sub.n Ar--Y--H (V)The nucleophile is reacted with a reagent containing an allyl derivative and a catalyst in an aqueous phase containing at least one element of group VIII of the Classification of the elements. A water-soluble phosphine may also be present in the reagent, and the reagent may also contain at least one organic phase.Type: GrantFiled: August 2, 1991Date of Patent: September 21, 1999Assignee: Rhone-Poulenc ChimieInventors: Jean-Michel Grosselin, Hubert Kempf, Jean-Pierre LeCouve
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Patent number: 5955631Abstract: The invention provides a method for industrial purification of Capsaicin in high purity from capsinoids (Capsaicin and analogues), more specifically, a method for industrial purification of Capsaicin which comprises contacting capsinoids containing Capsaicin in a hydrophilic solvent with a silver compound in an aqueous solution to form a Capsaicin-silver complex which is soluble in water, and recovering highly pure Capsaicin from the Capsaicin-silver complex without chromatography.Type: GrantFiled: July 16, 1998Date of Patent: September 21, 1999Assignee: Alps Pharmaceutical Ind. Co., Ltd.Inventors: Hisashi Segi, Shuji Yamada, Satoshi Kato, Shoji Murasugi
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Patent number: 5952528Abstract: A process for enhancing the purity of 2R-?1-hydroxy-1-trifluoromethyl-3-cyclopropylpropyn-2-yl!-4-chloroaniline comprising the formation of an acid addition salt which is capable of rejecting the racemate in the selected organic solvent.Type: GrantFiled: September 2, 1998Date of Patent: September 14, 1999Assignee: Merck & Co., Inc.Inventors: Cheng Yi Chen, Edward J. J. Grabowski, Paul J. Reider, Lushi Tan, Richard D. Tillyer
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Patent number: 5948937Abstract: This invention relates to a process for the preparation of N-phosphonomethylglycine and its salts. More particularly, this invention is directed to a method for preparing N-phosphonomethylglycine involving the reaction of AMPA, an alkali metal cyanide or hydrogen cyanide, and formaldehyde and hydrolyzing the product of that reaction to form N-phosphonomethylglycine and its salts.Type: GrantFiled: September 5, 1997Date of Patent: September 7, 1999Assignee: Monsanto CompanyInventors: Jimmy W. Worley, Melvin L. Rueppel, James C. Peterson, Sherrol L. Baysdon
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Patent number: 5945558Abstract: A method is disclosed for making dibasic amino acid monoesters useful in repair of teeth in which a dibasic amino acid is partially esterified with an allylic acrylic compound in the presence of an acidic ion-exchange resin at ambient temperature. The invention also comprises cyclicizing the amino groups of the monoesters.Type: GrantFiled: July 1, 1997Date of Patent: August 31, 1999Assignee: Southwest Research InstituteInventor: William A. Mallow
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Patent number: 5945451Abstract: The present invention relates to new fluorobutenyl (thio)ethers of the formula (I) ##STR1## in which R.sup.1 represents hydrogen or halogen,R.sup.2 and R.sup.3 independently of one another represent hydrogen or in each case optionally substituted alkyl, cycloalkyl, aryl, aralkyl or hetaryl,R.sup.4 represents hydrogen, or represents in each case optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, hetaryl and additionally represent a metal ion equivalent or an ammonium ion if Z represents oxygen,X represents oxygen or sulphur,Y represents oxygen or sulphur,Z represents oxygen, sulphur or the radical NR.sup.5 in whichR.sup.5 represents hydrogen, in each case optionally substituted alkyl, aryl, aralkyl, hetaryl or the radical ##STR2## in which R.sup.6 and R.sup.7 independently of one another represent hydrogen, in each case optionally substituted alkyl, aryl, aralkyl, or together represent optionally substituted alkanediyl andR.sup.Type: GrantFiled: June 16, 1997Date of Patent: August 31, 1999Assignees: Bayer Aktiengesellschaft, Monsanto CompanyInventors: Udo Kraatz, Jurgen Hartwig, Wolfram Andersch, Christoph Erdelen, Andreas Turberg, Norbert Mencke, Peter Gerrard Ruminski
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Patent number: 5942543Abstract: A topical anesthetic includes about 1-10% by weight lidocaine hydrochloride, about 0.01-0.10% by weight adrenaline, and about 0.25-4% by weight tetracaine hydrochloride, preferably in an aqueous base with about 2% benzyl alcohol or in a gel including about 3% hydroxyethyl cellulose. The topical anesthetic has been found to be at least as effective as TAC (tetracaine hydrochloride, adrenaline, cocaine), but with fewer harmful side effects and at a greatly reduced cost (about 1/10 of the cost of TAC).Type: GrantFiled: December 16, 1996Date of Patent: August 24, 1999Inventor: Amy A. Ernst
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Patent number: 5939581Abstract: Processes for preparing aromatic carboxylic acids. Cinnamaldehyde is hydrogenated to produce a mixture of hydrogenation products, namely, hydrocinnamaldehyde and hydrocinnamic alcohol. The mixture is then oxidized using a suitable oxidizing agent to substantially completely convert both hydrocinnamaldehyde and hydrocinnamic alcohol to hydrocinnamic acid.Type: GrantFiled: August 20, 1997Date of Patent: August 17, 1999Assignee: First Chemical CorporationInventors: August John Muller, Joseph Stanton Bowers, Jr., John Robert Ira Eubanks, Carey Cecil Geiger, John Gabriel Santobianco
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Patent number: 5936126Abstract: A process for the hydrogenation of an aromatic compound, in which at least one hydroxyl group is attached to an aromatic core, or an aromatic compound, in which at least one amino group is attached to an aromatic core, in the presence of a catalyst containing, as active metal, ruthenium and optionally one or more other Group IB, VIIB, or VIIIB metals, applied to a macroporous support.Type: GrantFiled: June 18, 1997Date of Patent: August 10, 1999Assignee: BASF AktiengesellschaftInventors: Thomas Ruhl, Boris Breitscheidel, Jochem Henkelmann, Wolfgang Reif, Helmuth Menig, Sabine Weiguny
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Patent number: 5932767Abstract: Protriptyline can be prepared from 5-dihydrodibenzocycloheptatriene, by deprotonation, followed by reaction at low temperatures with 1,3-bromochloropropane to give the 5-(chloropropyl)-dibenzocycloheptatriene, which is reacted with methylamine in a displacement reaction to give the protriptyline product.Type: GrantFiled: December 22, 1997Date of Patent: August 3, 1999Assignee: Merck & Co., Inc.Inventors: Robert S. Hoerrner, Joseph Auerbach, John Carolan
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Patent number: 5932769Abstract: A process for the production of aliphatic amines by reacting aliphatic alcohols with an amino compound in the presence of a catalyst containing at least two inter-dispersed metals, in a multi-metallic structure, in which at least one of the metals is nickel or cobalt, and at least one other metal is palladium, platinum, rhodium, ruthenium, or copper.Type: GrantFiled: January 26, 1998Date of Patent: August 3, 1999Assignee: Air Products and Chemicals, Inc.Inventors: Gamini Ananda Vedage, Kathryn Sue Hayes, Malee Leeaphon, John Nelson Armor
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Patent number: 5929282Abstract: An apparatus and method for converting hydrazine, substituted hydrazines and/or other nitrogen-containing explosive materials, particularly unsymmetric dimethyl hydrazine (UDMH), to ammonia or ammonia and the corresponding amines by hydrogenation are disclosed. The hydrazines are diluted with a suitable carrier fluid, preferably water, mixed with hydrogen, then hydrogenated in a catalyst reactor, followed by separation of the commercially valuable ammonia and amines. Separated carrier fluid and hydrogen gas may be recycled in to the process to conserve energy and reduce waste. Recycled carrier fluid may be used to preheat the diluted hydrazine prior to hydrogenation. Ammonia may be dissociated and the resultant hydrogen recycled into the hydrogenation process. The apparatus is sized for disassembly and transport for shipping to hydrazine disposal sites.Type: GrantFiled: March 16, 1998Date of Patent: July 27, 1999Assignee: AlliedSignal Inc.Inventors: Ken Sendelsky, Brent S. DeFeo, Russell W. Johnson, Subramaniam E. Haran, Alexander M. Bershitsky, Martin Andren, John Yamanis
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Patent number: 5925789Abstract: The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.Type: GrantFiled: April 6, 1998Date of Patent: July 20, 1999Assignee: DuPont Pharmaceuticals CompanyInventors: Michael E. Pierce, Cheng Y. Chen, Anusuya Choudhury, Lilian A. Radesca, Lushi Tan, Dalian Zhao