Patents Examined by Brian R. Gordon
  • Patent number: 10444251
    Abstract: Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: October 15, 2019
    Assignee: HighRes Biosolutions, Inc.
    Inventors: Michael Nichols, Louis J. Guarracina
  • Patent number: 10435737
    Abstract: A droplet generating apparatus, system, and method are disclosed. Based on a relative vibration between a micro-pipe and a container containing a second liquid, a first liquid flowing out from an outlet end of the micro-pipe can be detached from the micro-pipe by a fluid shear force of the second liquid to form droplets in the second liquid. Multitudinous quantitative and uniform droplets can be generated precisely and accurately in the present disclosure.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: October 8, 2019
    Inventors: Wenbin Du, Peng Xu, Libing Dong
  • Patent number: 10435187
    Abstract: A recapper for placing foils on laboratory sample containers is presented. The foils are brought on the sample container by a lever arrangement that is rotated around a vertical axis.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 8, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Markus Hegel
  • Patent number: 10427151
    Abstract: Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from a pipette tip coupler mounted on a pipette device. The pipette tip couplers include a proximal elastomeric element, a distal elastomeric element, and a coupler stop shoulder surface between the elastomeric elements. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a tip stop shoulder surface at the interface of the first and second cylindrical sections, a third cylindrical section distal to the second cylindrical section, and a sealing seat surface at the interface of the second and third cylindrical sections. When the pipette tip is mounted on the pipette tip coupler, the proximal elastomeric element abuts the tip groove, the coupler stop shoulder surface abuts the tip stop shoulder surface, and the distal elastomeric element abuts the sealing seat surface.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: October 1, 2019
    Assignee: Hamilton Company
    Inventors: Jose Eduardo Guzman, Thomas Barresi, Dana A. Belton
  • Patent number: 10429403
    Abstract: A head device for mounting a dispensing tip includes a piston member, a first shaft member to move the piston member in an up-down direction, a tubular rod including a tubular space having a cylinder space in which the piston member is housed to move in the up-down direction and including a tip mounting portion into which a base end portion of the dispensing tip is fitted, a first frame equipped with the first shaft member and the tubular rod, a second shaft member engaging with the first frame to move the first frame, a second frame equipped with the second shaft member and including a guide portion configured to guide movement of the tubular rod in the up-down direction in association with the movement of the first frame in the up-down direction, and a shaft controller configured to control operation of the first and second shaft members.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: October 1, 2019
    Inventors: Saburo Ito, Yukimasa Osada, Yohei Izume
  • Patent number: 10427150
    Abstract: A pipetting apparatus for aspirating and dispensing liquids having a pipetting unit with an interchangeable vessel that receives a liquid to be transferred, a holder for the pipetting unit, a positioning device for the pipetting unit, a micrometering unit, and an electronic control device. The micrometering unit is embodied separately from the pipetting unit and has a separate electronic control unit. The pipetting unit has a coupling device and the micrometering unit has a counterpart coupling device that matches the coupling device for the purpose of coupling. Coupling device and/or counterpart coupling device is/are switchable. The holder or the micrometering unit has a contact device with at least one electrical contact element and the micrometering unit or the holder has a counterpart contact device, matching the contact device, with at least one counterpart electrical contact element for making electrical contact with the contact element.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: October 1, 2019
    Assignee: BRAND GMBH + CO KG
    Inventors: J├╝rgen Schraut, Steffen Gehrig
  • Patent number: 10406521
    Abstract: The invention provides a micro-droplet array formation apparatus. The apparatus includes a first plate configured for delivering and/or extracting fluids, a second plate aligned to the first plate and configured for preparing the fluid and a third plate removably aligned to the second plate and is configured for forming a micro-droplet array of the prepared fluid.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: September 10, 2019
    Inventors: Ashwin Lal, Ankit Shantilal Purohit, Madhavi Phani Singaraju
  • Patent number: 10406526
    Abstract: The present invention is an article or device to facilitate the heating of rounded vessels and other rounded objects comprising a plurality of nested, concentric hollow cylinders each having respective upper edges and inner sides and adapted to be arranged and fixed in at least two configurations such that the upper edges and inner sides of the hollow cylinders form at least two bowl-shaped contours. Also included is a device for taking the impetus of a first rotating magnetic field to create the impetus of a second rotating magnetic field at some distance from the first rotating magnetic field, in order for the impetus of second magnetic field to stir the contents of a vessel by means of a magnet placed in the vessel.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: September 10, 2019
    Inventor: Bernard Robert McKellar
  • Patent number: 10401372
    Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: September 3, 2019
    Inventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Peter Bajka
  • Patent number: 10376876
    Abstract: A pipette is described having a tube, a pressure mechanism, and at least one reagent pad. The tube has a first end, a second end opposite the first end, and a sidewall extending between the first end and the second end, with the sidewall defining an interior cavity. The pressure mechanism is operably connected to the first end of the tube and is configured to enable a sample to be drawn into the interior cavity of the tube through the second end of the tube. The at least one reagent pad is positioned in the interior cavity of the tube and within a predefined liquid path whereby the sample contacts at least a portion of the at least one reagent pad when drawn into the interior cavity. In another embodiment, a pipette is described having a tube, a pressure mechanism, and a capillary positioned within the tube.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: August 13, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: James A. Profitt
  • Patent number: 10369536
    Abstract: An apparatus for generating one or several droplets of a first liquid in a second liquid immiscible with the first liquid includes a rotational body and a drive apparatus. The rotational body includes a fluid chamber, a fluid channel and a transition area. The transition area includes a first expansion area and a second expansion area. The drive apparatus is configured to provide the rotational body with such a rotation that the first liquid is supplied centrifugally to the fluid chamber and that centrifugally hydrodynamically induced pressure and lifting forces are caused due to the second expansion area, which cause a droplet break-off in the first liquid, such that a droplet of the first liquid embedded in the second liquid is generated.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: August 6, 2019
    Assignee: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.
    Inventors: Frank Schwemmer, Friedrich Schuler
  • Patent number: 10363557
    Abstract: An apparatus for processing a biological sample is provided. The apparatus has a body having a processing chamber, a first reservoir, a second reservoir, a filter, a first one-way valve, a second one-way valve, a third one-way valve, a first fluid pathway, a second fluid pathway, and a third fluid pathway.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 30, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Jon A. Kirschhoffer, Gregory W. Sitton, Andrew H. Tilstra
  • Patent number: 10357771
    Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: July 23, 2019
    Assignee: 10X Genomics, Inc.
    Inventors: Rajiv Bharadwaj, Anthony Makarewicz, Bill Kengli Lin
  • Patent number: 10343168
    Abstract: A reagent-loaded pencil, method of preparing a reagent-loaded pencil, and a system that uses reagent-loaded pencils are disclosed. The reagent-loaded pencil or pencils include a matrix of at least a soluble carrier, a hardening substance, and a reagent. The pencils also include a sheath disposed around at least a portion of the matrix. The soluble carrier may include poly(ethylene glycol) methyl ether. The hardening substance may leave a visible mark when abraded against a writing surface. One example of such a substance includes graphite. The sheath may be the outside of a wooden pencil or a mechanical pencil. A system that uses reagent-loaded pencils or compressed matrices may include a computer-controlled plotter that holds and plots with at least one of the reagent-loaded pencils or matrices.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: July 9, 2019
    Assignee: Cal Poly Corporation
    Inventors: Andres W. Martinez, Haydn T. Mitchell, Chad E. Immoos, Nathaniel W. Martinez, Philip J. Costanzo, Samantha J. Carlton
  • Patent number: 10343169
    Abstract: A device for use in molecular diagnostics testing includes at least one reagent storage container, the reagent storage container being sealed; at least one opener for unsealing the reagent storage container; and an actuator. The actuator is coupled to at least one of the reagent storage container and the opener such that moving the actuator brings the reagent storage container and the opener together so that the opener unseals the reagent storage container, but inadvertently opening is prevented.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: July 9, 2019
    Assignee: Koninklijke Philips N.V.
    Inventor: Ronald Cornelis De Gier
  • Patent number: 10323223
    Abstract: A vessel having a mixer that ensures a homogeneous cell distribution in dispensed quantities. The vessel has a mixer therein for stirring contents of the vessel and an orifice in a lower wall to which a cell dispenser is attached. The cell dispenser dispenses quantities of suspended cells having a homogeneous cell distribution.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: June 18, 2019
    Assignee: PBS Biotech, Inc.
    Inventors: Chanyong Brian Lee, Yasunori Hashimura, Oscar Garza, Gary Evans
  • Patent number: 10300479
    Abstract: The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array. The spotter apparatus includes a loading surface, including a first well and a second well, and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: May 28, 2019
    Assignee: Carterra, Inc.
    Inventors: Bruce Kent Gale, Adam Miles, Joshua Wayne Eckman, Sriram Natarajan, Jim Smith, Mark Eddings
  • Patent number: 10300488
    Abstract: Provided herein are anti-static pipette trays that reduce the amount of static charge accumulated on or in pipette tips and allow for discharge of any accumulated static charge.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 28, 2019
    Assignee: Biotix, Inc.
    Inventors: Arta Motadel, Scott Edward Curry
  • Patent number: 10302534
    Abstract: A filter device (1) for filtering complex fluid samples including a first filter funnel (2) having an inlet (2a), an outlet (2b) and a first internal space (2c), and a second filter funnel (3) having an inlet (3a), an outlet (3b) and a second internal space (3c). The first and second filter funnels (2,3) are sequentially arranged with a first filter medium (4) located therebetween such that a volume of sample fluid placed in the first internal space (2c) can pass through the first filter medium (4) and be collected in the second internal space (3c). An intermediate connector (12) is provided between the first filter medium (4) and the internal space (3c). The intermediate connector (12) has a port (13) and/or a vent for communicating the internal second space (3c) with an external gas source/atmosphere and/or a vacuum source via a valve arrangement (14).
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: May 28, 2019
    Inventors: Philippe Rivat, Sylvain Frey
  • Patent number: 10302665
    Abstract: An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: May 28, 2019
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Kurt Reinhardt, Charles D. Lemme, Glen Ward, William L. Richards, Wayne Showalter, Brandon Ambler, Austin Micheil Ashby, Chris Borchert, Devon C. Campbell, Kimberly Christensen, Matthew Freeman, Andrew Ghusson, Rick Griebel, Kendall B. Hendrick, Miroslav Holubec, Parula Mehta, Vince Rizzo