Patents Examined by Brian R. Gordon
  • Patent number: 11561175
    Abstract: A method for the detection of hydrocarbon contamination in a sample is disclosed. The method includes contacting a sample with a molecular probe. The molecular probe has a photoluminescence which is environmentally sensitive. The photoluminescence from the molecular probe is collected. The method includes determining whether the photoluminescence is indicative of a hydrocarbon contaminated sample. A test strip for the detection of hydrocarbon contamination in a sample is also disclosed. The test strip includes a molecular probe embedded in a substrate and/or immobilized to the substrate, the molecular probe having a photoluminescence which is environmentally sensitive to hydrocarbon contaminated sample.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: January 24, 2023
    Assignee: Bundesrepublik Deutschland, vertreten durch die Bundesministerin für Wirtschaft und Energie, diese vertreten durch den Präsidenten der Bundesanstalt für Materialforgchung und- Prüfung (BAM)
    Inventors: Raúl Gotor, Jérémy Bell, Knut Rurack
  • Patent number: 11561156
    Abstract: Devices and methods for the deposition of reagents onto cells or tissue samples are disclosed. Also disclosed are reagent compositions suitable for dispensing via a droplet-on-demand system.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: January 24, 2023
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Henning Groll, Melis Hazar, Eric L. Klein, Raymond T. Kozikowski, III, Chana R. Paluszcyk, Melinda J. Polaske, Raviraj Thakur
  • Patent number: 11559802
    Abstract: An adapter for connecting an array of pipette tips having through bores with conical upper ends to a multichannel air displacement pipettor having a plurality of ports with compliant internal sealing surfaces. The adapter comprises a planar base with an array of openings extending between its top and bottom surfaces. Sealing tubes project upwardly from the top surface, and tip mounting tubes project downwardly from the bottom surface, with pairs of sealing tubes and tip mounting tubes being arranged coaxially and in communication with respective ones of the openings in the base. The tip mounting tubes are externally dimensioned and configured for insertion into the conical upper ends of the pipette tips, and the sealing tubes are externally configured and dimensioned for insertion into the ports of the pipettor and into sealing interengagement with their compliant internal sealing surfaces.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: January 24, 2023
    Assignee: Avidien Technologies, Inc.
    Inventor: Richard Cote
  • Patent number: 11554368
    Abstract: The present invention provides a pipette tip, which can be used in in-vitro diagnostics, in particular in the diagnostic testing of body fluids, such as in coagulation testing. The Pipette tip contains two constituents in a spatially separated manner. The present invention furthermore provides a method of performing such diagnostics, e.g. coagulation analysis, and to the use of the pipette tip in such diagnostic testing.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: January 17, 2023
    Inventor: James Lynn Hill
  • Patent number: 11541403
    Abstract: A system and method of fluid delivery for providing a surface fluid pattern. The system includes a fluid delivery head for fluid flow therethrough. The fluid delivery head includes a fluid delivery surface having surface openings defined therein and arranged across the fluid delivery surface as a two-dimensional display. Some of the surface openings are grouped as a surface opening unit. The surface opening unit includes at least one aspiration opening through which fluid can be provided to the fluid delivery surface and at least one injection opening through which fluid can be moved away from the fluid delivery surface. The surface opening unit includes at least three surface openings positioned as a two-dimensional display and outwardly of at least one other surface opening.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: January 3, 2023
    Inventors: Thomas Gervais, Pierre-Alexandre Goyette, Etienne Boulais
  • Patent number: 11543424
    Abstract: A manual-electronic pipetting device for pipetting a medium. The pipetting device includes a controller, a manually displaceable actuating element, at least one piston for aspirating and discharging the medium, a motor for driving the at least one piston in response to an actuation and/or displacement of the actuating element, at least one sensor for determining a displacement of the actuating element, and a data storage. The controller determines a pipetting protocol based on at least one sensor signal of the at least one sensor during a displacement of the actuating element, the controller further storing the pipetting protocol in the data storage, the pipetting protocol including data records indicative of a position and a speed of the at least one piston during the displacement of the actuating element.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: January 3, 2023
    Inventors: Stefan Scheuermann, Roger Steinbrenner, Ulrich Ackermann
  • Patent number: 11534750
    Abstract: Embodiments of lab automation workstations are disclosed in which the pod that performs pipetting operations is integrated with pipette tip-loading functionality. To generate the necessary tip-loading force, a dual drive system is used that is symmetric about the Y-axis to allow for offset or partial tip box loads by dynamically centering the drive force (e.g., the tip-loading force) over the reaction load. This minimizes the need for oversized linear motion components while still allowing for the generation of high tip-loading forces needed to properly load a large number of pipette tips simultaneously.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: December 27, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Matthew S. Davis, Ronald Douglas Johnson, Mark A. Nierzwick, Craig A. Hudson, Charles M. Neese, Mark F. Sauerburger, John S. Snider
  • Patent number: 11536634
    Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
    Type: Grant
    Filed: December 24, 2020
    Date of Patent: December 27, 2022
    Assignee: Hologic, Inc.
    Inventors: Barry F. Hunt, Raymond Jenoski, Ryan Oliva, Michael Cordeiro, Eric Grimes
  • Patent number: 11529656
    Abstract: A wash station includes a wash nozzle for cleaning an exterior portion of a probe and a basin allowing for waste fluid to be collected. The wash nozzle includes a vertically-elongate cavity with side slits on opposing side portions. A fluid inlet port may be connected to a side portion of the cavity to provide fluid. Fluid may additionally or alternatively come from within the probe. The basin includes an elongate body with an opened end to receive and secure the wash nozzle. One or more access slots may be provided on opposing side portions of the basin. The probe passes through an access slot or over a portion of the basin and through a side slit of the nozzle to enter the cavity for cleaning. A geometry of the cavity allows the wash nozzle to fill to a predetermined level while waste fluid flows out through the side slits.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: December 20, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: William D. Dunfee, Thomas E. Weitkamp
  • Patent number: 11524286
    Abstract: A method for the contact metering of liquids having the following steps: a first liquid is introduced into at least one elongate hollow body, some of the first liquid contained in the elongate hollow body is pressed out of the lower end of the elongate hollow body as a contacting volume such that the contacting volume forms a drop suspended from the lower end of the elongate hollow body, at least some of the drop is immersed in a second liquid in a target vessel and the defined metering volume consisting of the contacting volume and a residual volume contained in the elongate hollow body is dispensed into the second liquid.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: December 13, 2022
    Inventor: Rusbeh Göcke
  • Patent number: 11525759
    Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: December 13, 2022
    Assignee: Agilent Technologies, Inc.
    Inventors: Adrienne Mccampbell, Victor Lim
  • Patent number: 11519771
    Abstract: One embodiment provides a method for detecting aspiration in a clinical analyzer, including: acquiring, from a sensor, pressure measurement data; transforming the pressure measurement data into frequency domain data; generating a clean version of the frequency domain data by attenuating, using a filter, unwanted frequencies; comparing the cleaned version of the frequency domain data to one or more predetermined data points; and determining, based on the comparison, if an aspiration was properly performed. Other aspects are described and claimed herein.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 6, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: William D. Dunfee, Stephen Krufka, Mark H. Sprenkle, Colin Ingersoll
  • Patent number: 11511300
    Abstract: A liquid discharging device to be used with a liquid dispensing apparatus includes a discharging portion configured to discharge a liquid based on a control signal from the liquid dispensing apparatus on which the liquid discharging device is mounted, and a sheet material having a characteristic configured to be changed by the liquid dispensing apparatus after a discharge of the liquid by the discharging portion.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: November 29, 2022
    Inventors: Shuhei Yokoyama, Satoshi Kaiho, Ryutaro Kusunoki, Seiya Shimizu
  • Patent number: 11511278
    Abstract: A solid reagent containment unit is formed by a support; a frame body fixed to the support and delimiting internally, together with the support, an analysis volume; a reagent-adhesion structure within the analysis volume; and at least one reagent cavity, which extends within the reagent-adhesion structure. The reagent-adhesion structure is of an adhesion material embossable at temperatures lower by 6-8° C. than its own melting point and has a melting point such as not to interfere with the analysis. The reagent cavity forms a retention wall, laterally surrounding the reagent cavity, and houses dried reagents. The adhesion material is chosen among wax, such as paraffin, a polymer, such as polycaprolactone, a solid fat, such as cocoa butter, and a gel, such as hydrogel or organogel.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 29, 2022
    Inventors: Marco Cereda, Lillo Raia, Alessandro Paolo Bramanti
  • Patent number: 11513133
    Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: November 29, 2022
    Inventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Bajka
  • Patent number: 11506677
    Abstract: Systems and methods applicable, for instance, to pipette robots. A pipette robot can perform one or more operations regarding deck calibration, one or more operations regarding pipette tip/probe calibration, one or more operations regarding pipette tip pick up, and/or one or more operations regarding tip ejection.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: November 22, 2022
    Assignee: Opentrons Labworks Inc.
    Inventors: Andrew Sigler, Taylor Schlaff Goodman, Nicholas Pease Starno, Jonathan Preston Badal
  • Patent number: 11499183
    Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: November 15, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David P. Stumbo, George Carman, Steve Hobbs, Anthony J. Makarewicz, Jr., Dmitri Simonian, David Glade, Joshua Oen, Denis Pristinski, John Dzenitis
  • Patent number: 11498065
    Abstract: Systems and methods for positive dispense verification are disclosed. In one embodiment, a system has a plurality of light emitters. The light from the emitters is directed toward a plurality of light detectors across a proximately horizontal plane. The liquid dispense device is positioned above the horizontal plane of light emission from the plurality of light emitters to the plurality of light detectors such that the dispensed liquid will travel through the horizontal plane defined by the emitted light and onto the container being inoculated. Each of the plurality of detectors is coupled to an amplifier. The amplifier generates a signal in response to an interrupt in the transmission of light from the light emitters to the light detectors when the light path is disrupted by the dispense of liquid confirming the liquid was dispensed onto the container.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: November 15, 2022
    Inventors: Timothy Roy Hansen, Zhou Tong
  • Patent number: 11498064
    Abstract: A photometric dispensing nozzle unit, a photometric dispensing apparatus, and a photometric dispensing method are for preventing an increase in apparatus scale and have a simple structure to be easily handled. A nozzle performs suction/discharge of gas through a distal end opening and can have a dispensing tip attached thereto. A light guide end portion is provided in the nozzle and can receive or irradiate light at a distal end of the nozzle. A dispensing cylinder has a cylinder having a cavity therein, a plunger that is slidable in the cavity, and a suction/discharge port that performs suction/discharge of gas. A suction/discharge flow path passes through the nozzle and communicates with the suction/discharge port and the distal end opening of the nozzle. A light guide path is optically connected to the light guide end portion through the nozzle but not through the dispensing cylinder.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: November 15, 2022
    Assignee: Universal Bio Research Co., Ltd.
    Inventors: Hideji Tajima, Kazuhiro Nakamura, Yu Sugiyama
  • Patent number: 11491478
    Abstract: A dispensing cylinder capable of performing a dispensing treatment for both minute and large amounts of liquid includes: a cylinder having a cavity; a nozzle provided at one end of the cylinder, having a through hole in fluid communication with the cavity and extending in an axial direction of the cavity, and a plunger slidable in the cavity in the axial direction. The cavity has a large diameter region having a large inner peripheral surface and a small diameter region having a second inner peripheral surface. The plunger has a thick shaft portion slidable in the large diameter region and a thin shaft portion protruding from a distal end of the thick shaft portion in the axial direction and slidable in the small diameter region.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: November 8, 2022
    Assignee: UNIVERSAL BIO RESEARCH Co., Ltd.
    Inventors: Hideji Tajima, Kazuhiro Nakamura, Yu Sugiyama