Patents Examined by Bridge E Bunner
  • FGFR extracellular domain acidic region muteins
    Patent number: 8338569
    Abstract: Fibroblast growth factor receptor (FGFR) extracellular domain (ECD) acidic region muteins that have been engineered to exhibit decreased tissue binding by increasing the number of acidic amino acid residues within the D1-D2 linker region are provided. Polynucleotides encoding FGFR ECD acidic region muteins are also provided. Methods of making FGFR ECD acidic region muteins, and methods of using such molecules to treat proliferative disorders, including cancers, disorders of angiogenesis, and macular degeneration, are also provided.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: December 25, 2012
    Assignee: Five Prime Therapeutics, Inc.
    Inventors: Shannon Marshall, Deborah H. Charych, Ali Sadra