Abstract: The invention provides methods, kits and reagents for diagnosing fibromyalgia (FM) in an individual by determining whether the levels of one or more cytokines in the individual are altered, as compared to control levels. The altered level(s) or patterns of expression of the cytokines measured in the affected individual compared to the level from the control is predictive/indicative of FM in the individual.
Abstract: Treatment and diagnostic methods are provided for pulmonary disease, including chronic obstructive pulmonary disease. Various pro-inflammatory mediators are elevated in a model of COPD that can be used predict the presence of COPD and/or subtypes of COPD in human patients. Profiles of these mediators can also predict the responsiveness of some patients to certain therapies, including thromboxane receptor antagonist treatment. Methods are provided for diagnosing a subject as a pulmonary disease candidate that include determining leukocyte expression in the subject of at least one pro-inflammatory mediator and identifying the subject as a pulmonary disease candidate when leukocyte expression in the subject of the pro-inflammatory mediator is increased compared to leukocyte expression of the pro-inflammatory mediator in a healthy individual. The pulmonary disease candidate can also be treated by administering a therapeutically effective amount of a thromboxane receptor antagonist.
Type:
Grant
Filed:
April 9, 2013
Date of Patent:
June 12, 2018
Assignees:
NATIONAL JEWISH HEALTH, A NON-PROFIT ORGANIZATION, THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
John M. Hartney, Raul M. Torres, Roberta Pelanda
Abstract: Glycated hemoglobin (HbA1c) levels and other characteristics of diabetes are reduced by administering to a human subject a pharmaceutical composition that includes a pharmaceutically acceptable carrier and a therapeutically effective amount of an agent that selectively binds IL-1?.
Abstract: Provided is a method of refolding of recombinant GCSF that minimizes the generation of oxidized forms of GCSF by optimizing the refolding of inclusion bodies containing recombinant GCSF.
Abstract: Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
Abstract: Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.
Type:
Grant
Filed:
October 26, 2015
Date of Patent:
May 8, 2018
Assignee:
Teva Pharmaceuticals Australia Pty Ltd.
Inventors:
Adam Clarke, Matthew Pollard, Anthony Gerard Doyle, Collette Behrens, Tetsuo Yamagishi, David S. Wilson, Jr., Sarah L. Pogue, Tetsuya Taura
Abstract: The present invention provides compositions and methods of treating and improving the symptoms of rheumatoid arthritis using an antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R).
Type:
Grant
Filed:
October 10, 2012
Date of Patent:
April 17, 2018
Assignees:
SANOFI BIOTECHNOLOGY, REGENERON PHARMACEUTICALS, INC.
Inventors:
Martine Jasson, Vanessa Marks, Xiaohong Huang, Allen Radin
Abstract: This invention provides a method for treating tumors in a subject, comprising administering to the subject an effective amount of a recombinant interferon, wherein the interferon has the amino acid sequence of SEQ ID NO:2 and is encoded by the nucleotide sequence SEQ ID NO:1, wherein the tumors are selected from the group consisting of skin cancer, basal cell carcinoma, liver cancer, thyroid cancer, rhinopharyngeal cancer, solid carcinoma, prostate cancer, esophageal cancer, pancreatic cancer, superficial bladder cancer, hemangioma, epidermoid carcinoma, cervical cancer, glioma, leucocythemia, acute leucocythemia, chronic leucocythemia, lymphadenoma, and polycythemia vera.
Abstract: A method of treating obesity and obesity-related disorders in a mammal is provided. The method comprises the step of administering to the mammal a compound that inhibits the synthesis or activity of peripheral serotonin, including a Tph1 inhibitor or a serotonin receptor inhibitor.
Type:
Grant
Filed:
February 14, 2014
Date of Patent:
April 10, 2018
Assignee:
McMaster University
Inventors:
Waliul Khan, Gregory Steinberg, Palanivel Rengasamy
Abstract: A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.
Type:
Grant
Filed:
April 13, 2016
Date of Patent:
April 3, 2018
Assignee:
IRX Therapeutics, Inc.
Inventors:
James E. Egan, Martin Kast, Harvey Brandwein
Abstract: The present application relates to treatment of cutaneous wounds using IL-12. The methods of the invention result in improved wound closure. The methods comprise treating cutaneous wounds using topical, subcutaneous, and/or intramuscular administration of IL-12.
Type:
Grant
Filed:
June 13, 2012
Date of Patent:
March 27, 2018
Assignee:
NEUMEDICINES, INC.
Inventors:
Lena A. Basile, Dolph Ellefson, Timothy K. Gallaher
Abstract: The present invention relates to a composition containing an inducer of SIRT1 (silent mating type information regulation 2 homolog) expression for preventing or treating sepsis or septic shock. The inducer of SIRT1 expression can remarkably reduce the mortality caused by sepsis or septic shock by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines. Therefore, the inducer of SIRT1 expression is useful for preventing or treating sepsis or septic shock.
Type:
Grant
Filed:
February 17, 2012
Date of Patent:
March 13, 2018
Assignee:
STEMDR INC.
Inventors:
Myung Kwan Han, Chae Hwa Yoo, Eun Kyung Song, Seung Ok Lee
Abstract: The present invention relates to a pharmaceutical composition comprising a histone-lysine N-methyltransferase EZH2 (enhancer of zeste homolog 2) inhibitor and an enhancer of interferon-gamma receptor activity. The invention also relates to method of treating a patient having cancer, comprising administration of the pharmaceutical composition.
Type:
Grant
Filed:
November 19, 2013
Date of Patent:
February 13, 2018
Assignee:
Agency for Science, Technology and Research
Abstract: This invention relates to the administration of an animal immunoglobulin source to mammals such as dairy cattle to improve milk production without negatively affecting reproductive parameters.
Type:
Grant
Filed:
September 14, 2015
Date of Patent:
January 23, 2018
Assignee:
The Lauridsen Group Incorporated
Inventors:
Francisco Javier Polo Pozo, Joy M. Campbell, Louis E. Russell, Alejandro Bach Ariza
Abstract: Methods are disclosed for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes using interleukin 1 receptor accessory protein and other targets.
Type:
Grant
Filed:
August 9, 2012
Date of Patent:
January 23, 2018
Assignee:
Albert Einstein College of Medicine, Inc.
Inventors:
Ulrich G. Steidl, Laura Barreyro De Pujato, Britta Will, Amit Verma
Abstract: Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.
Type:
Grant
Filed:
January 18, 2011
Date of Patent:
January 16, 2018
Assignee:
Hanmi Science Co., Ltd.
Inventors:
Mi Ji Lee, Jae Min Lee, Byung Sun Lee, Sung Min Bae, Se Chang Kwon
Abstract: Methods and compositions for treating and alleviating symptoms of irradiation injuries, therapeutic radiation intervention and/or anti-cancer therapies in a subject via pulmonary airway administration of granulocyte macrophage colony stimulating factor (GM-CSF) or a compound with similar affinity to the specific alveolar GM-CSF receptor to enhance pulmonary host defense are provided.
Abstract: This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure.
Abstract: A composition and method for using a composition, the composition having at least two compounds, each of which induces indolamine 2,3-dioxygenase, for the treatment of an autoimmune disorder or disease or immune rejection of transplants or gene therapeutically modified cells, wherein the inducers have different mechanism of action and wherein the composition gives rise to a synergistic effect on the IDO levels.
Type:
Grant
Filed:
November 25, 2014
Date of Patent:
December 12, 2017
Assignee:
Idogen AB
Inventors:
Leif Salford, Hans Olov Sjogren, Bengt Widegren
Abstract: Administration of an antibody that specifically binds IL-1? is useful for treating cachexia and increasing the lifespan of a subject suffering from cachexia.