Patents Examined by Bruce R. Campbell
  • Seeding treatments
    Patent number: 6209259
    Abstract: This invention pertains to combination seed capsules wherein each seed capsule includes both moieties of at least one soil conditioner and at least one seed, and optionally, one or more inorganic chemical fertilizer, growth enhancer, binder, and/or anti-fungal agent. The combination seed capsules are made by physically combining the respective soil conditioner and seed with one other, in the absence of any requirement for chemical reactions in the process of so combining the respective materials.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: April 3, 2001
    Assignee: Encap, LLC
    Inventors: Daniel Paul Madigan, Michael Dennis Krysiak, Ronald Dean Eichhorn, Glen H. Wesenberg
  • Pea3 is a tumor suppressor
    Patent number: 6172212
    Abstract: The present invention relates generally to the fields of cancer therapy and gene therapy. More particularly, it demonstrates that PEA3 is a tumor suppressor and may be used to treat various forms of cancer, and especially neu-mediated cancer.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: January 9, 2001
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mien-Chie Hung, Xiangming Xing
  • Replication-competent Herpes simplex virus mediates destruction of neplastic cells
    Patent number: 6139834
    Abstract: A method for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the .gamma.34.5 gene and the ribonucleotide reductase gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and yet is not neurovirulent.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: October 31, 2000
    Assignee: Georgetown University
    Inventors: Robert L. Martuza, Samuel D. Rabkin, Toshihiro Mineta
  • Nettle lectin cDNA
    Patent number: 6133507
    Abstract: A cDNA encoding a chitin-binding protein of nettle lectin (Urtica dioica) and subunits thereof is described. The cDNA is incorporated into a vector so as to be transformed into a plant. A synthetic gene encoding a chitin binding protein is also described.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: October 17, 2000
    Assignee: Board of Trustees operating Michigan State University
    Inventor: Natasha V. Raikhel
  • 3-ketoacyl-ACP-reductase (FabG) of Staphylococcus aureus
    Patent number: 6110704
    Abstract: The invention provides fabG polypeptides and polynucleotides encoding fabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: August 29, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Damien McDevitt
  • Oral delivery or adeno-associated viral vectors
    Patent number: 6110456
    Abstract: A method of expressing a gene product in the gut of an animal, which comprises administering a recombinant AAV vector to the gut of the animal, wherein the vector comprises a non-AAV gene of interest ligated into an AAV vector genome.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 29, 2000
    Assignee: Yale University
    Inventor: Mathew John During
  • Universal donor cells
    Patent number: 6100443
    Abstract: Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a coding region which provides protection against complement-based lysis, i.e., hyperacute rejection. In addition, the cell's natural genome is changed so that functional proteins encoded by either the class II or both the class I and the class II major histocompatibility complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally, the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 8, 2000
    Assignees: Oklahoma Medical Research Foundation, Yale University
    Inventors: Peter J. Sims, Alfred L. M. Bothwell, Eileen A. Elliot, Richard A. Flavell, Joseph Madri, Scott Rollins, Leonard Bell, Stephen Squinto
  • Transgenic pomaceous fruit with fire blight resistance
    Patent number: 6100453
    Abstract: The present invention relates to a method of conferring resistance against fire blight to pomaceous fruit scion or rootstock cultivars by transforming such cultivars with a gene which encodes for lytic proteins. Such transformation can be effected by bacterial infection or propulsion of particles into cell interiors. Once transformation has taken place, the cultivar is regenerated to a transgenic pomaceous fruit tree. This technique is particularly useful in treating apple and pear cultivars.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: August 8, 2000
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Herbert S. Aldwinckle, John L. Norelli
  • Genetically engineered mice containing alterations in the gene encoding RXR
    Patent number: 6093873
    Abstract: The present invention is directed to mice which are genetically altered to be deficient in the normal expression of RXR.gamma., to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The invention further provides mice and cell lines which, in addition to being deficient in RXR.gamma., are genetically altered to be deficient in the expression of RXR.alpha. and/or RXR.beta.. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of RXR.gamma., or the normal expression thereof, is desirable.
    Type: Grant
    Filed: August 19, 1997
    Date of Patent: July 25, 2000
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, Bristol-Myers Squibb Company
    Inventors: Pierre Chambon, Philippe Kastner
  • Adenovirus vectors generated from helper viruses and helper-dependent vectors
    Patent number: 6080569
    Abstract: The present invention provides an improved helper-dependent vector system for production of high capacity adenoviral cloning vectors. The invention makes use of the DNA size packaging constraints imposed on a pIX-defective Ad virion that prevent such virions from packaging DNA larger than approximately 35 kb. This constraint can be used to develop helper viruses that do not package their DNA. In one embodiment, the invention combines this methodology with the Cre-loxP helper-dependent system to decrease the quantity of contaminating helper virus in vector preparations. In another embodiment the invention is used for vector growth.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: June 27, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Frank L. Graham, Robin Parks, Liane Chen
  • Methods for creating transgenic animals
    Patent number: 6080912
    Abstract: The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: June 27, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert D. Bremel, Anthony W. S. Chan, Jane C. Burns
  • Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy
    Patent number: 6080728
    Abstract: Carrier complexes comprising DNA encoding an anti-angiogenic gene or peptide and optionally a further DNA encoding a tumor suppressor protein are described. When administered to a subject bearing a tumor, the complexes can inhibit growth of the tumor.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: June 27, 2000
    Inventor: A. James Mixson
  • Cellular composition for the treatment of human or animal organisms
    Patent number: 6074637
    Abstract: Composition designed to treat human or animal organisms comprising cells expressing genes enabling them to secrete in vivo one or more biologically-active substances, said cells exhibiting genetic characteristics preventing them from growing durably in the treated organism, and making them susceptible to elimination artificially or naturally from the organism. These compositions can be used in particular in the treatment of tumors or cancers, in which case the substances used are interleukins. The cells contained in these compositions are at least partially allogenic or xenogenic.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 13, 2000
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale
    Inventors: Claude Roth, Lluis M. Mir, Philippe Kourilsky
  • Nucleic acid fragments encoding portions of the core protein of the human mammary epithelial mucin
    Patent number: 6054438
    Abstract: Nucleic acid fragments are described which can be used as probes for detecting one of the strands of the DNA tandem repeat sequence in the gene encoding the core protein of human polymorphic epithelial mucin, or incorporated into an expression vector to encode a portion of the mucin core protein to be used for immunization purposes.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 25, 2000
    Assignee: Imperial Cancer Research Technology Limited
    Inventors: Joyce Taylor-Papadimitriou, Sandra Gendler, Joy Burchell
  • Variety of petunia named ‘Trumpet Neon Rose’
    Patent number: PP11825
    Abstract: The claimed cultivar brings a new color to the Trumpet series of Petunias and is characterized by a large purple rose colored flower accented in its center with a large and distinctive yellow-white circular center, over medium green foliage. As with all Trumpet Petunias, this cultivar exhibits early flowering with superior branching so that the plant may also be used in a hanging pot.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: March 27, 2001
    Assignee: John Bodger and Sons Company
    Inventor: Mike Heffner
  • Hibiscus plant named ‘Crown Jewels’
    Patent number: PP11857
    Abstract: A new and distinct cultivar of winter hardy hibiscus plant named, ‘Crown Jewels’ is the result of a unique hybridization. This new and distinct cultivar is characterized primarily as to its low-growing nature, its extreme cold hardines to Zone 4, its dark purple “maple-cut leaf”, its ruffled white flowers with red partially-streaking centers, and its vigorous and uniform growth habit, and its floriforous nature from midsummer until frost.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: May 1, 2001
    Assignee: Fleming's Flower Fields, Inc.
    Inventors: David W. Fleming, Gretchen A. Zwetzig
  • Fern plant named ‘Regina’
    Patent number: PP11864
    Abstract: A distinct cultivar of Fern plant named ‘Regina’, characterized by its upright and outwardly arching plant habit; relatively compact growth habit; rapid growth rate; durable rachis; numerous pinnae per frond that are dark green, glossy and curly; and closely-spaced pinnae.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: May 8, 2001
    Assignee: Milestone Agriculture, Inc.
    Inventor: Antonio Cifrian
  • New guinea impatiens plant named `Balcelelro`
    Patent number: PP11651
    Abstract: A new and distinct cultivar of New Guinea Impatiens plant named `Balcelelro`, characterized by its reddish purple-colored flowers; floriferousness; upright and mounded plant habit; relatively tall plant size; vigor; good basal branching; and dark brown leaves.
    Type: Grant
    Filed: February 20, 1999
    Date of Patent: November 28, 2000
    Assignee: Ball Floraplant, a division of Ball Horticultural Co.
    Inventor: Scott C. Trees
  • New Guinea impatiens plant named `Balcelvago`
    Patent number: PP11652
    Abstract: A new and distinct cultivar of New Guinea Impatiens plant named `Balcelavgo`, characterized by its dark lavender-colored flowers; floriferousness; upright and mounded plant habit; medium plant size; vigor; good basal branching; and dark green leaves.
    Type: Grant
    Filed: February 20, 1999
    Date of Patent: November 28, 2000
    Assignee: Ball Floraplant, a division of Ball Horticultural Co.
    Inventor: Scott C. Trees
  • Variety of Petunia named `Trumpet Chiffon`
    Patent number: PP11670
    Abstract: The claimed cultivar brings a new color to the Trumpet series of Petunias and is characterized by a deep salmon colored flower delicately accented at its center with green over a medium green foliage. As with all Trumpet Petunias, this cultivar exhibits early flowering with superior branching so that the plant may also be used in a hanging pot.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: December 5, 2000
    Assignee: John Bodger and Sons Company
    Inventor: Mike Heffner