Abstract: The invention relates to monoclonal antibodies which differentially bind oxidation-specific epitopes on lipoprotein in blood, arterial tissue and vascular tissue, including atherosclerotic plaque formed in arterial tissue and vascular tissue through lipoprotein oxidation. Methods for use of the antibodies in detecting and monitoring lipoprotein oxidation in vivo and in vitro are described, as are methods for inhibiting lipoprotein oxidation in vivo.
Type:
Grant
Filed:
August 7, 1997
Date of Patent:
May 1, 2001
Assignee:
The Regents of the University of California
Inventors:
Joseph L. Witztum, Wulf Palinski, Sohvi Hörkkö, Daniel Steinberg
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