Patents Examined by Bryan James Rego
  • Patent number: 12263188
    Abstract: Some embodiments include methods of treating, inhibiting, or ameliorating ischemic stroke or a symptom thereof in a subject. Some embodiments include oxygenated fluid for use in treating, inhibiting, or ameliorating ischemic stroke. The oxygenated fluid may comprise charge-stabilized oxygen-containing nanostructures.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: April 1, 2025
    Assignee: Revalesio Corporation
    Inventors: Supurna Ghosh, Helmut Andreas Kalmes
  • Patent number: 12239687
    Abstract: Non-aqueous membrane emulsion methods for producing polymeric and polymer-coated microparticles are provided. Some embodiments provide methods for producing a sustained release or controlled release microparticle by combining micronized protein powder and a polymer into a hydrocarbon solvent to form a non-aqueous first solution, agitating the first non-aqueous solution to form a suspension, feeding the suspension into a dispersion pump, wherein the suspension is infused through a porous membrane into a continuous phase comprising a fluorocarbon liquid and a fluorosurfactant to form a hydrocarbon-in-fluorocarbon emulsion. The hydrocarbon solvent, the fluorocarbon liquid, and the fluorosurfactant are removed, and the microparticles are collected.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: March 4, 2025
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Hunter Chen, Yiming Zhao
  • Patent number: 12239613
    Abstract: The present invention provides a preparation method for a carotenoid preparation having high bioavailability and high stability, comprising the following steps: a) dissolving part of a water-soluble colloid and a filling substance in water to form an aqueous phase; b) adding a carotenoid crystal to the aqueous phase and stirring for dispersion so as to form a dispersion liquid; c) loading the dispersion liquid into a first-stage grinding machine for first grinding to form a first-stage grinding liquid; d) adding the remaining water-soluble colloid and filling substance to the first-stage grinding liquid, loading same into a second grinding machine for secondary grinding to obtain a second-stage grinding liquid; and e) drying the moisture in the second-stage grinding liquid to obtain carotenoid dry powder or particles.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: March 4, 2025
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Xinde Xu, Di Zhou, Tian Xie, Shuangming Ye, Shengnan Wang
  • Patent number: 12220472
    Abstract: Processes and kits-of-parts reshape keratin fibers and comprise applying a composition on to keratin fibers and cover the keratin fibers, wherein the composition comprise an alkalizing agent, a thickening polymer, and an organic solvent. Additionally, the keratin fibers are put under tension using a curler along with covering the curler with a moisture barrier, and heating the keratin fibers. As a result, long-lasting curl having cosmetic properties are achievable.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: February 11, 2025
    Assignee: KAO GERMANY GMBH
    Inventors: Steven Breakspear, Niu Jian, Bernd Nöcker
  • Patent number: 12213993
    Abstract: Medicinal clay compositions and pharmaceutical compositions containing the same are disclosed. The medicinal clay compositions provide a protective barrier for the clay allowing manufacturing, storage and use that protects the medicinal clay from moisture and hydration that would otherwise prematurely activate the clay. The medicinal clay compositions allow use of medicinal clays in various delivery systems and types of therapeutic compositions, including foams, hydrocolloids, electrospinning, films, pastes, and the like. Methods of preparing the medicinal clay compositions and methods of use are also disclosed. Methods of using the medicinal clay compositions, pharmaceutical compositions, and cation sources to reduce microbial populations on a subject and/or remove chloride from exudate from a tissue or organ in need of treatment are also disclosed.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: February 4, 2025
    Inventor: Darlene E. McCord
  • Patent number: 12208151
    Abstract: Hair treatment compositions and methods for using them is described. The hair treatment compositions include: (a) one or more fatty alcohols; (b) one or more cationic surfactants; (c) one or more cationic polymers; (d) one or more nonionic polymers; (e) citric acid, salts thereof, or combinations thereof; and (f) water.
    Type: Grant
    Filed: October 27, 2022
    Date of Patent: January 28, 2025
    Assignee: L'OREAL
    Inventors: Liliana Xavier, Kazumitsu Kawakami
  • Patent number: 12201717
    Abstract: The present disclosure is directed to the use of a composition comprised of: (1) a first active blend of at least: (a) Jojoba oil/Macadamia seed oil esters; (b) squalene; (c) phytosteryl macadamiate; and (d) phytosterols; (2) a second active blend of at least: (e) EGF growth factor; (f) IGF-1 growth factor; (g) acidic FGF growth factor; (h) basic FGF growth factor; (i) VEGF growth factor; (j) vitamin B9; and (k) acetyl glutamine; and (3) a third active blend of at least: (l) an extract of lithothamnium calcareum; (m) pentylene glycol; (n) lactic acid; and (o) glycerin; (4) an emulsifier; and (5) a dermatologically acceptable carrier which, when applied onto skin, helps to positively influence inflammation, hydration, and keratinocyte hyperproliferation, thereby supporting skin barrier health, integrity, and functionality.
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: January 21, 2025
    Assignee: Skinfix Inc.
    Inventors: Amy Gordinier, Marc Cornell, Erica Arnoldin
  • Patent number: 12186450
    Abstract: A composition for bone regeneration includes substantially spherical granules. Each of the spherical granules include an outer shell including magnesium phosphate and nano-sized silica and a bioactive core encapsulated by the outer shell. The granules include macro-pores and micro-pores. The macro-pores are intergranular spaces between adjacent granules, and the micro-pores are intragranular nanopores formed on the outer shell of each of the granules. A method of producing the substantially spherical granules, includes providing a mixture of a biological active powder, magnesium phosphate, and an initiator with a colloidal silica solution; rotating the mixture with dual asymmetric centrifugation for a predetermined amount of time; and drying the resulting material.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: January 7, 2025
    Assignee: OSTEONOVUS LLC
    Inventors: Anand Agarwal, Xiaodong Gao, Smruti Gore
  • Patent number: 12161743
    Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: December 10, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Long Pan, Ravi Subramanyam
  • Patent number: 12128139
    Abstract: The present invention relates to microparticles that can be used as drug-loaded hydrogel particles for embolization and a method for manufacturing same. The microparticles of the present invention have a very excellent anticancer agent adsorption ability, a short anticancer agent adsorption time, and a controllable decomposition time when administered in vivo. Therefore, when the microparticles of the present invention are used in chemoembolization, not only the anticancer effect is excellent, but also side effects can be minimized.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: October 29, 2024
    Assignee: NEXTBIOMEDICAL CO., LTD.
    Inventors: Yi Xian Li, Choong Ryeol Choi
  • Patent number: 12064504
    Abstract: The present disclosure relates to stable cosmetic compositions containing high amounts of acetyl trifluoromethylphenyl valylglycine. The cosmetic compositions further include high amounts of hydroxypropyl tetrahydropyrantriol, taurate copolymers, fatty alcohols, fatty compounds (other than the fatty alcohols), nonionic emulsifiers, and water. Methods for stabilizing cosmetic compositions containing high amounts of acetyl trifluoromethylphenyl valylglycine and methods for treating the skin with the cosmetic compositions is also described.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: August 20, 2024
    Assignee: L'OREAL
    Inventors: Jonathan James Faig, Yon Jae Yoon, Susan Halpern Chirch, Angelike Galdi