Patents Examined by Bryan Kilpatrick
  • Patent number: 10549276
    Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: February 4, 2020
    Assignee: International Business Machines Corporation
    Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
  • Patent number: 10545073
    Abstract: The present disclosure relates to a method and a solid phase microextraction sampling instrument for inserting into or through a solid or semisolid material to extract a component of interest from a sample, comprising a support structure at least partially coated with an extraction phase for extracting the component of interest, a protrusion that shields the coating during insertion, where the distances within a cross-sectional plane of the sampling instrument are greater than or equal to the corresponding distances in all of the cross-sectional planes located between the cross-sectional plane of interest and the insertion end of the sampling instrument. The present disclosure also discusses methods of making the instrument, desorption chambers, and methods for desorbing a component of interest from the instrument.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 28, 2020
    Assignee: JP SCIENTIFIC LIMITED
    Inventors: Janusz Boleslaw Pawliszyn, Justen James Poole, Jonathan James Grandy, Barbara Bojko
  • Patent number: 10545128
    Abstract: The present invention discloses a device for measuring adsorption/desorption of contaminants onto surface bed sediments and a method of using the device. The measurement device includes a sediment sample disc, a sample holder, a reaction cylinder, a liquid collection cylinder, and a liquid circulating member from inside to outside, the liquid circulating member consisting of rubber pipes and a peristaltic pump.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: January 28, 2020
    Assignee: Hohai University
    Inventors: Hongwu Tang, Qingxia Li, Yang Xiao, Zhiwei Li, Saiyu Yuan
  • Patent number: 10525464
    Abstract: Microscale fluidic devices and components thereof having a fluid retention groove, as well as systems and methods related thereto. The fluid retention groove facilitates uniform bonding of microfluidic device components.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: January 7, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Alwin Wan, Amir Sadri, Tal Rosenzweig, Nenad Kircanski, Edmond Young
  • Patent number: 10493448
    Abstract: In one arrangement, a cartridge includes a cartridge body defining a holding compartment, first and second fractioning compartments, and a number of flow channels formed within the cartridge body. A predetermined quantity of fluid can be held in the holding compartment when the cartridge body is held in a first orientation, and can be poured from the holding compartment to the first fractioning compartment by rotating the cartridge body about a predefined rotation axis to a second orientation, spilling the fluid from the holding compartment to the first fractioning compartment through one of the flow channels. The first fractioning compartment is such that when the cartridge body is in the second orientation, not all of the fluid can be contained in the first fractioning compartment, and fluid that overflows the first fractioning compartment flows through a second flow channel to the second fractioning compartment.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: December 3, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Glenn Price, Chris Charlton, William Link, Robert Alan Iovanni, Anthony F. Prestigiacomo
  • Patent number: 10493444
    Abstract: A pipetting device (100) for an apparatus for processing a sample or reagent is disclosed. The pipetting device (100) comprises a coupling mechanism, wherein the coupling mechanism comprises at least a first coupling unit (104) adapted to be coupled to a first pipetting tip (108) and a second coupling unit (106) adapted to be coupled to a second pipetting tip (110), and a selection element (138) for selectively allowing a coupling of the first coupling unit (104) to or releasing the first coupling unit (104) from the first pipetting tip (108) and for selectively allowing a coupling of the second coupling unit to or releasing the second coupling unit (106) from the second pipetting tip (110). The selection element (138) is mechanically coupled to the first coupling unit (104) and the second coupling unit (106). Further, an apparatus (198) for processing a sample or reagent and a method for pipetting a sample or reagent are disclosed.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: December 3, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hans-Rudolf Bachmann, Rolf Schneebeli, Geza Burghardt, Kurt Barmettler
  • Patent number: 10449502
    Abstract: The present invention is generally related to the analysis of chemical compositions of hydrocarbons and hydrocarbon blends. This method, in particular embodiments, may apply specifically to the problem of analyzing extremely complex hydrocarbon-containing mixtures when the number and diversity of molecules makes it extremely difficult or impossible to realistically identify and quantify them individually in a reasonable timeframe. Particular SEC (size exclusion chromatography)-based methods and apparatus disclosed herein may be used to measure, e.g., the molecular size, weight, and/or volume, whether in absolute or relative manner, of the various components of eluate from the SEC stationary phase (e.g., a permeable gel). This analytical method is applicable on a wide variety of hydrocarbonaceous materials, and especially useful for, but not limited to oil, maltenes of oil, asphalt binders and asphalt binder blends, which may contain wide varieties of different types of additives, modifiers, and chemistries.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: October 22, 2019
    Assignee: The University of Wyoming Research Corporateion
    Inventors: Joseph F. Rovani, Jr., Jean-Pascal Planche, Ryan Bradley Boysen
  • Patent number: 10434513
    Abstract: A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon. The central region includes an outer periphery that defines a first fluid constraint configured for discouraging fluid on the central region from flowing therepast. A second fluid constraint extends about the first fluid constraint. The second fluid constraint is configured for discouraging fluid flowing therepast. A third fluid constraint extends about the second fluid constraint. The third fluid constraint configured for discouraging fluid flowing therepast.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: October 8, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, David J. Guckenberger, Jr., Scott M. Berry, Hannah M. Pezzi
  • Patent number: 10434508
    Abstract: A capsule (100) comprising a housing (110) in which are disposed nanofluidic biosensors (120), a fluid connecting element (140), a filter (150) and a cover (160) is described. The capsule (100) allows the analysis of a fluid sample (300) that would be deposited in the capsule system (100) by a pipette (400). The fluid sample (300) is filtered when passing through a filter (150), then transferred by a fluid connecting element (140) to the inlets of one or several nanofluidic biosensors (120). The capsule system (100) is disposed on an external support (200), and finally an optical or an electrical measurement unit (500) is used to measure the molecular interactions in the nanofluidic biosensors.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: October 8, 2019
    Assignee: Abionic SA
    Inventors: Iwan Maerki, Lauriane Carrere, Nicolas Durand
  • Patent number: 10391488
    Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: August 27, 2019
    Assignee: International Business Machines Corporation
    Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
  • Patent number: 10384209
    Abstract: A microfluidic platform including a microfluidic layer and a contact layer. The microfluidic layer is embedded with a microfluidic structure including a micro-channel and a fluidic sample contained in the micro-channel. The contact layer is able to be attached to the microfluidic layer, and includes a first heater for heating a first area of the microfluidic structure to a first temperature and a second heater for heating a second area of the microfluidic structure to a second temperature. The microfluidic layer and the contact layer rotate together during operation. A method for controlling a sample in the micro-channel of the microfluidic structure.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: August 20, 2019
    Assignees: THE CHINESE UNIVERSITY OF HONG KONG, NANYANG TECHNOLOGICAL UNIVERSITY, HOSPITAL AUTHORITY
    Inventors: Qiu Lan Chen, Ho Pui Ho, Siu Kai Kong, Patrick Kwok Leung Kwan, Yiu Wa Kwan, Ho Chin Kwok, Ping Shum, Yick Keung Suen, Shu Yuen Wu, Alice Kar Lai Yang, Jun Qiang Zhou
  • Patent number: 10376884
    Abstract: Systems and methods disclosed herein related to an apparatus including a fluid flow plate and a microfluidic valve assembly. The fluid flow plate includes a plurality of polymer layers that define a fluid flow passage through the microfluidic valve assembly. The microfluidic valve assembly includes a valve seat, a flexible membrane, a valve cavity, a valve head, and an actuator. The actuator is configured to selectively control pressure applied by the valve head to the flexible membrane, such that in a first actuator state the valve head depresses the flexible membrane into the valve cavity and into contact with the valve seat, thereby preventing fluid flow through the valve assembly, and in a second state, the valve head and the flexible membrane are retracted substantially out of the valve cavity allowing fluid to flow through the valve assembly. In various implementations, the valve seat and/or the flexible membrane include an elastomer layer.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: August 13, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Mark Joseph Mescher, Jonathan Robert Coppeta, Abigail June Spencer, Brett Isenberg
  • Patent number: 10379055
    Abstract: Gas detector tube templates are described. Gas detector tubes may be used to determine the concentration of target gases in a sampled gas either visually or electronically. Gas detector tubes for visual reading have the length-of-stain demarcations printed or etched on the transparent tube. However, the demarcations may interfere with electronic reading of gas detector tubes. Embodiments of a gas detector tube template may be used to accurately and reliably read gas detector tubes that do not have concentration demarcations printed on the tube in the working area adjacent to the chemical reagent. The gas detector tube template may have a gas detector tube holder capable of reversibly receiving a gas detector tube and two scale card holders. The gas detector tube template could have a left and right scale holder hingedly connected to the gas detector tube holder. The gas detector tube template may be used with scale cards capable of being, reversibly received in the scale rockets.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: August 13, 2019
    Assignee: Nextteq LLC
    Inventor: Bryan I. Truex
  • Patent number: 10369572
    Abstract: A reagent dispensing apparatus includes a housing having a cavity with an opening and an aperture; and a plunger that includes a first member, that fits through the aperture, that is associated with a first seal. The plunger includes a second member associated with the first seal and a second seal that together form a first chamber, within the cavity, in which a first reagent is stored. The plunger includes a safety mechanism that controls movement of the plunger within the cavity. The apparatus includes a frangible seal that covers the opening and together with the second seal forms a second chamber, within the cavity, that stores a second reagent. When the first end is depressed and the safety mechanism is disengaged, the frangible seal is breached causing the evacuation of the first reagent or the second reagent through the opening.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: August 6, 2019
    Assignee: Point of Care Diagnostics, LLC
    Inventor: William Francis Marion, Jr.
  • Patent number: 10330574
    Abstract: A biological fluids concentration device, including a tube-in-tube assembly, is disclosed. The tube-in-tube assembly receives biologic fluids and may then be placed in the bucket of a centrifuge and spun to separate out the components of the biological fluid by their various densities. For example, whole blood may be centrifuged in the tube-in-tube assembly for separating into plasma, red blood cell component, and a buffy coat. A piston slideably and sealingly engages an inner tube of the tube-in-tube assembly, the inner tube fitting within an outer tube. A lid is designed to engage the top of the outer tube, which lid has an opening therein for receipt of a plunger. The plunger is adapted to move up and down with respect to the lid and the tubes, so as to sealingly, in a down position, and unsealingly, in an open position, engage the top of the inner tube of the tube-in-tube assembly.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: June 25, 2019
    Assignee: ALLIANCE PARTNERS, LLC
    Inventors: Emad Hassouneh, Logan White, Matt Schmidt, Andrew Enke, Frank Morris
  • Patent number: 10300480
    Abstract: A pipetting device (100) for an apparatus (164) for processing a sample or reagent is disclosed. The pipetting device (100) comprises a coupling mechanism (102), wherein the coupling mechanism (102) comprises at least a first coupling unit (104) adapted to be coupled to a first pipetting tip and a second coupling unit (106) adapted to be coupled to a second pipetting tip, and a tilt mechanism (112) for moving the first coupling unit (104) between an untilted position, in which the first coupling unit (104) and the second coupling unit (106) are arranged parallel to one another, and a tilted position, in which the first coupling unit (104) is tilted relative to the second coupling unit (106).
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: May 28, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hans-Rudolf Bachmann, Rolf Schneebeli
  • Patent number: 10295441
    Abstract: A method for producing a pneumatically actuatable microfluidic analysis cartridge includes closing a joining side of a fluidic part of the analysis cartridge with a first fluid-tight elastic membrane and/or closing a joining side of a pneumatic part of the analysis cartridge with a second membrane. The fluidic part is configured to perform fluidic basic operations of a biochemical analysis process, and the pneumatic part is configured to control the basic operations using air pressure. The joining side of the fluidic part and the joining side of the pneumatic part are aligned, and the fluidic part and the pneumatic part are connected to form the analysis cartridge.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: May 21, 2019
    Assignee: Robert Bosch GmbH
    Inventors: Franz Laermer, Juergen Steigert, Sven Zinober
  • Patent number: 10295458
    Abstract: An analytical device for determining a parameter of a liquid sample, especially a digestion parameter, such as chemical oxygen demand, total carbon content or total nitrogen content, comprising a reactor, and measuring system for ascertaining the parameter of the liquid sample. A container system for storing samples, reagents and waste products in containers, a transport and dosing system for metering and transporting the sample and reagents from the containers into a metering container and for disposal of waste products from the metering container into a waste container, and a measuring transducer for registering a measured parameter correlating, measured value of the liquid sample mixed in the reactor, and measuring, system, in given cases, with one or more reagents is provided.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: May 21, 2019
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Marco Volker, Sofia Reim, Anja Gerlinger, Xu Zhou
  • Patent number: 10288590
    Abstract: Disclosed herein are devices and methods for determining the pH of fluid. Example devices include a device comprising a surface configured to contact the fluid and a pH indicator covalently bound thereto, wherein the pH indicator has a first color prior to contact with the fluid and changes color as a function of the pH of the fluid.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: May 14, 2019
    Assignee: Smith & Nephew PLC
    Inventors: Victoria Jody Hammond, John Kenneth Hicks
  • Patent number: 10281407
    Abstract: A multi-fluid test strip may include a first zone to test a first fluid, a second zone to test a second fluid, and a third zone intermediate the first zone and the second zone. The third zone may prevent cross-contamination of the first fluid with the second zone and prevent cross-contamination of the second fluid with the first zone. The multi-fluid test strip may also include a first grip zone and a second grip zone. The first zone may be intermediate the first grip zone and the third zone and the second zone may be intermediate the second grip zone and the third zone. The first grip and second grip zones may be dimensioned to permit gripping of the first and second grip zones without touching the first or second zones.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: May 7, 2019
    Inventor: Jon A. Petty