Patents Examined by Bryan Kilpatrick
  • Patent number: 10981166
    Abstract: Described herein are pipette driven well plates for nano-liter droplet storage and methods of using same. Embodiments may include an inlet, an outlet, a bypass channel, and a fluidic trap containing a valve covered by a removable covering, in which the fluid enters the fluidic trap when the removable covering is removed. The fluid enters either the fluidic trap or the bypass channel, depending on which of the fluidic trap or bypass channel has the lower hydrodynamic resistance. Embodiments may be used by closing the valve, introducing a first fluid to fill the fluidic trap and partially fill a bypass channel, opening the valve, removing the first fluid surrounding the valve, and introducing a second fluid into the fluidic trap, in which the introducing results in a mixture of the first and second fluids.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: April 20, 2021
    Assignee: NEOFLUIDICS LLC
    Inventor: Deepak Solomon
  • Patent number: 10942163
    Abstract: Devices for micro-fluid mixing micro-fluids are presented, together with example methods for micro-mixing using example devices. An example device may include a micro-volume fluid chamber (?VFC), a micro-volume mixing chamber (?VMC), and a source of a target micro fluid. The ?VFC may include two slidably-mounted piston segments that divide the ?VFC into three sub-volumes, one of which initially contains a mixer micro-fluid. The source of the target micro fluid may be triggered to deliver the target micro-fluid into another of the sub-volumes via an inlet channel. A propellant may be triggered to drive axial motion of the piston segments, causing the sub-volumes to compress. Through this action, the mixer micro-fluid may be expelled via a first outlet channel into the ?VMC, and the target micro-fluid may be expelled via a second outlet channel into the ?VMC. As the piston segments move, they block and unblock the inlet and outlet channels.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: March 9, 2021
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Benjamin David Krasnow, Eric Peeters, Peter Howard Smith, Ethan Glassman
  • Patent number: 10935475
    Abstract: A biological fluids concentration device, including a tube-in-tube assembly, is disclosed. The tube-in-tube assembly receives biologic fluids and may then be placed in the bucket of a centrifuge and spun to separate out the components of the biological fluid by their various densities. For example, whole blood may be centrifuged in the tube-in-tube assembly for separating into plasma, red blood cell component, and a buffy coat. A piston slideably and sealingly engages an inner tube of the tube-in-tube assembly, the inner tube fitting within an outer tube. A lid is designed to engage the top of the outer tube, which lid has an opening therein for receipt of a plunger. The plunger is adapted to move up and down with respect to the lid and the tubes, so as to sealingly, in a down position, and unsealingly, in an open position, engage the top of the inner tube of the tube-in-tube assembly.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: March 2, 2021
    Assignee: ALLIANCE PARTNERS, LLC
    Inventors: Emad Hassouneh, Logan White, Matt Schmidt, Andrew Enke, Frank Morris
  • Patent number: 10926258
    Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: February 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Xander Frank Van Kooten
  • Patent number: 10913063
    Abstract: Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: February 9, 2021
    Assignee: Emulate, Inc.
    Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Kyung Jin Jang
  • Patent number: 10898893
    Abstract: A method for forming a microchannel or microfluidic reservoir is described. Methods provided herein include applying a covering over a recess formed in a substrate and bonding the covering to the substrate along seams. Methods provided herein use a substrate having elevated edge regions bordering the recess that project from the surface of the substrate. Bonding seams nm a distance from the elevated edge regions of the recess such that the covering and the elevated edge regions are pressed against each other. Devices for bonding substrates and coverings to make microchannels and microfluidic reservoirs are also provided herein. Devices provided herein can include pressing elements for holding the substrate and the covering together. Pressing elements provided herein can include recesses and/or elastic layers positioned opposite to one or more recesses in a substrate.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: January 26, 2021
    Assignee: THINXXS MICROTECHNOLOGY AG
    Inventor: Lutz Weber
  • Patent number: 10888859
    Abstract: Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: January 12, 2021
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Peter Paul Blaszcak
  • Patent number: 10875017
    Abstract: Described is a microfluidic serial dilution platform based well-plate using an oil-free immiscible phase driven by manual or electronic pipettors. The well-plate includes a plurality of fluidic traps, a plurality of hydrophilic capillary constriction channels and a plurality of bypass channels. Each of the plurality of bypass channels is associated with one of the plurality of fluidic traps, each of the plurality of hydrophilic capillary constriction channels is associated with one of the plurality of fluidic traps, and each of the plurality of fluidic traps is associated with one of the plurality of bypass channels and one of the plurality of hydrophilic capillary constriction channels. The well-plate further includes an inlet, an outlet, and a main channel with a plurality of portions that connects the inlet to the plurality of fluidic traps, associated hydrophilic capillary constriction channels and associated bypass channels, and the outlet.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 29, 2020
    Assignee: NEOFLUIDICS LLC
    Inventors: Deepak Solomon, Nilesh Gupta
  • Patent number: 10864162
    Abstract: Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials) at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: December 15, 2020
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: YongTae Kim, Zahi Fayad, Willem J. Mulder, Edward Fisher, Francois Fay, Omid C. Farokhzad, Robert Langer
  • Patent number: 10850273
    Abstract: There is provided a master for micro flow path creation, a transfer copy, and a method for producing a master for micro flow path creation by which transfer copies having an area with high hydrophilicity can be easily mass-produced, the master for micro flow path creation including: a base material; a main concave-convex portion provided on a surface of the base material and extending in a planar direction of the base material; and a fine concave-convex portion provided on a surface of the main concave-convex portion and having a narrower pitch than the main concave-convex portion. The fine concave-convex portion has an arithmetic average roughness of 10 nm to 150 nm and has a specific surface area ratio of 1.1 to 3.0.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: December 1, 2020
    Assignee: DEXERIALS CORPORATION
    Inventors: Shinya Suzuki, Kazuya Hayashibe, Akihiro Shibata
  • Patent number: 10801946
    Abstract: A method for manufacturing a device for electronically monitoring the consumption of gas adsorbent media in a media bed includes forming a monitoring rod of a corrosion resistant material. A plurality of sensors are attached to an exterior surface of the monitoring rod, and a communication channel is routed between each sensor and the connecting rod.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: October 13, 2020
    Assignee: Pure Air Filtration, LLC
    Inventor: Kevin F. Jameson
  • Patent number: 10788457
    Abstract: A method of detecting at least a partial blockage in a porous member separating an inner chamber of a device having a gas sensor responsive to an analyte positioned within the inner chamber and an ambient environment includes emitting pressure waves within the inner chamber and measuring a response via a sensor responsive to pressure waves positioned within the inner chamber.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: September 29, 2020
    Assignee: MSA Technology, LLC
    Inventors: Jerin Miller, Ryan Alan Sherry, Robert Kevin Sexton, Robert Eric Uber
  • Patent number: 10788458
    Abstract: A method of detecting at least a partial blockage in a porous member separating an inner chamber of a device having a gas sensor responsive to an analyte positioned within the inner chamber and an ambient environment includes emitting pressure waves within the inner chamber and measuring a change in phase of a response via a sensor responsive to pressure waves.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: September 29, 2020
    Assignee: MSA Technology, LLC
    Inventors: Jerin Miller, Ryan Alan Sherry, Robert Kevin Sexton, Robert Eric Uber
  • Patent number: 10788507
    Abstract: A fluid delivery system and process for fluid delivery is provided that is useful in in flow-injection based sensing measurements, wherein samples from a sample rack are introduced into a flow cell where sensing measurements are taken. The system and process utilize at least two holding lines where each holding line can retain one of the samples prior to injection of the thus retained sample into a flow cell. The introduction of the samples from the sample racks to the holding lines is alternated and the injection of the samples from the holding lines to the flow cell are alternated so that one holding line is loaded with one of the samples simultaneously with another sample being injected from the another holding line to the flow cell.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: September 29, 2020
    Assignee: Sartorius Bioanalytical Instruments, Inc.
    Inventor: Christopher Iver Strande
  • Patent number: 10768108
    Abstract: A Surface Plasmon Resonance (SPR) biosensor system comprising: a SPR sensor surface, an illumination unit arranged to direct a wedge shaped beam of light at a line shaped detection area on the SPR sensor surface transverse to the direction of propagation of light, and a detection unit with detection optics for directing light reflected from the SPR sensor surface onto a two-dimensional optical detector unit such that the angle of reflection is imaged along one dimension and the width of the detection area along the other, wherein the illumination unit is arranged to selectively direct the wedge shaped beam of light at two or more spaced apart line shaped detection areas on the SPR sensor surface transverse to the direction of propagation of light.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: September 8, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Bengt Ivarsson, Stefan Sjolander
  • Patent number: 10768116
    Abstract: A multi-fluid test strip may include a first zone to test a first fluid, a second zone to test a second fluid, and a third zone intermediate the first zone and the second zone. The third zone may prevent cross-contamination of the first fluid with the second zone and prevent cross-contamination of the second fluid with the first zone. The multi-fluid test strip may also include a first grip zone and a second grip zone. The first zone may be intermediate the first grip zone and the third zone and the second zone may be intermediate the second grip zone and the third zone. The first grip and second grip zones may be dimensioned to permit gripping of the first and second grip zones without touching the first or second zones.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: September 8, 2020
    Inventor: Jon A. Petty
  • Patent number: 10761000
    Abstract: In a liquid stirring method, after a second liquid is discharged into a reaction container accommodating a first liquid from a dispensing probe provided with a dispensing tip at the leading end thereof, a mixture of the first liquid and second liquid in the container is stirred by being sucked out and discharged by the dispensing probe. The number of stirrings through sucking out and discharging is changed according to the total volume of the first liquid and second liquid. If the total volume of the first liquid and second liquid is below a preset threshold, sucking out and discharging is repeated for a prescribed number of times.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: September 1, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Shunsuke Sasaki, Yoshihiro Yamashita
  • Patent number: 10761095
    Abstract: A microfluidic device including a serum separator, a quantum dot and antibody inlet connected to the serum separator, a quantum dot linked immunosorbent assay (QLISA) chamber connected to the serum separator, and an outlet connected to the QLISA chamber. The microfluidic device is configured to determine an amount of drug in a serum.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: September 1, 2020
    Assignee: COMSATS Institute of Information Technology
    Inventors: Madeeha Chaudhry, Malik Abdul Rehman, Raheel Qamar, Arshad Saleem Bhatti
  • Patent number: 10737273
    Abstract: Provided herein is a single-walled pipette tip rack comprising buttresses for use in automated systems, in some embodiments. Also provided herein is a partial single-walled pipette tip rack comprising posts.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: August 11, 2020
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Phillip Chad Hairfield, Peter Paul Blaszcak
  • Patent number: 10710075
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: July 14, 2020
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon