Abstract: A multi-pixel spectroscopy sensor for spectral analysis of a sample under test including an array of pixel elements generating a dataset including a plurality of data values corresponding to the pixel elements upon illumination of the sample by a light source. Each of the pixel elements including a stack of layers including first and second reflective structures, a phase tuning element, a detector element, and contact elements. The sensor further includes a read-out circuit connected to each of the contact elements for simultaneous read-out of a plurality of photocurrents for generating and outputting the dataset for the spectral analysis of the sample under test. The phase tuning element of each of the pixel elements is configured for a different wavelength response of the light and each photodetector of the pixel elements is comprised of a semiconductor material.

Abstract: A system for detection and coating analysis that comprises a digital camera and a light-based protractor positioned adjacent to or on a physical coating surface. The system identifyies a particular angular indication being displayed by the light-based protractor. The system then identifies a target color of the physical coating surface and identifies one or more target coating texture characteristics of the physical coating surface. Additionally, the system identifies a proposed coating that comprises a proposed color that matches the target color and proposed coating characteristics that match the one or more target coating texture characteristics. The system then displays, on a user interface, the proposed coating.

Abstract: A modular hand-held point of care testing system, which includes a plurality of different assay adapters configured to receive a plurality of different assay devices that perform assays on one or more samples; a shared door that that interchangeably receives the plurality of different assay adapters; wherein at least two of the plurality of assay adapters or at least two of the assay devices comprise different identifiers that distinguish the assays from each other; an apparatus comprising a portable frame configured to interchangeably receive the shared door and a means for decoding the different identifiers when received by the frame; and a means for reading assay results.

Abstract: A noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating a sclera may include at least one light source, at least one detector, and a processor. The at least one light source may direct incident light to illuminate a region of the sclera of an eye of the subject. The at least one detector may receive light, in response to the incident light, from the sclera or from inside the eye proximal to the illuminated region of the sclera. The processor may be configured to compute a ratio of an intensity of the received light from the at least one detector to a reference value and to estimate a level of a substance in the subject from the computed ratio.

Abstract: A method of measuring a gas concentration is described. The method comprises illuminating, with a light source, a volume of space that includes a gas and measuring, with a detector, a first illumination level of the volume of space. The method further comprises determining, via a processor, a gas concentration in the volume of space based on the measured first illumination level, where the volume of space is configured to be in fluid communication with a gas recirculation flow path including a catalyst, the catalyst configured to substantially remove the gas from the volume of space.

Abstract: The disclosure relates to a gas analysis method by Raman spectrometry, the method comprising the steps of generating by a laser source a laser beam sweeping a range of frequencies including a plurality of resonance modes of an optical cavity holding gases to be analyzed; delivering the laser beam into the cavity; extracting from the cavity a feedback beam that is sent adjusted in phase and amplitude to the source; during the frequency range sweeping, detecting light intensity peaks in the laser beam in the cavity, the phase of the feedback beam being adjusted to reduce shape asymmetries of the peaks, the amplitude of the feedback beam being adjusted to reduce intervals of zero intensity between the peaks; and performing a spectral analysis of the light inelastically scattered in the cavity, to determine the composition of the gases to be analyzed.

Abstract: Ultra-miniature spatial heterodyne spectrometers (SHSs) are presented. Ultra-miniature SHSs in accordance with the invention, comprise a beam-splitter and gratings configured to generate a fringe pattern for spectroscopic detection. Many embodiments include input optics and a sensor and are configured in a way to omit collimating optics and imaging optics from the SHS. Compared to conventional SHSs known in the art, the present invention enables fewer parts, significantly smaller and lighter SHSs, are more efficient and robust, and require less maintenance. Many embodiments are field-deployable, in that such embodiments can be deployed for hand held use in real-world or remote activities outside of research or diagnostic facilities.

Abstract: Corona Phase Molecular Recognition (CoPhMoRe) utilizing a template heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins.

Abstract: The present invention relates to an apparatus for optical applications, a spectrometer system and method for producing an apparatus for optical applications, and in particular to an apparatus comprising an optical waveguide having a first refractive index along a light propagation axis interrupted by a plurality of scattering portions having a second refractive index. Each scattering portion has a long axis substantially perpendicular to the light propagation axis as well as a short axis substantially perpendicular to the light propagation axis and the long axis. A receiver unit or a transmitter unit is arranged on a side of the optical waveguide, the long axis being substantially perpendicular, i.e. normal to the plane of this side on which the receiver unit or transmitter unit is arranged. Accordingly, simplification and miniaturization of an optical apparatus can be realized.

Abstract: A system for urine sample analysis, the system may include one or more transmitters for transmitting radiation; one or more sensors that are configured to receive received radiation that passed through the urine sample and to generate detection signals indicative of an intensity of the received radiation at multiple frequencies; detaching elements that are configured to detach the one or more transmitters and the one or more sensors to a toilet bowl; and a processor that is configured to participate in the urine sample analysis for determining a content of the urine sample based on the detection signals.

Abstract: Measurement apparatus including an optical sensor, which performs repeatedly transmission measurements through moving sheet of paper or board at at least one wavelength band dominantly absorbed by water, at at least one wavelength band dominantly absorbed by cellulose. The apparatus also includes an X-ray sensor, which performs repeatedly transmission measurements through the moving sheet of paper or board with photons of electromagnetic radiation (1 keV to 10 keV). The apparatus comprises a data processing unit, which receives signals with information on intensities of the optical and X-ray radiations passed through the sheet from the optical sensor and the X-ray sensor, and determines, based on the information, all of the following of the moving sheet: the dry stuff content as a function of the cellulose mass per unit area of the sheet, water mass per unit area of the sheet and the ash mass per unit area of the sheet.

Abstract: A concentration measurement device 100 includes a light source 22 for generating incident light to a measurement space 10A, a photodetector 24 for receiving light emitted from the measurement space, and an arithmetic control circuit 26 for calculating a concentration of a measurement fluid on the basis of an output of the photodetector, and the light source includes a first light-emitting element 22a for generating light having a first wavelength, and a second light-emitting element 22b for generating light having a second wavelength, and the concentration measurement device is configured so as to calculate the concentration using either light of the first wavelength or the second wavelength on the basis of the pressure or temperature of the measurement fluid.

Abstract: Systems and methods for characterizing biological specimens, which may involve identifying a cell type or state corresponding to a disease or health condition of a subject. A biological specimen is subjected to electromagnetic radiation for spectroscopic analysis such as Surface Enhanced Raman Spectroscopy (SERS) to determine the relative abundance of proteins or amino acids in the cells, which is used in a comparison to previously stored relative abundance data of a database to automatically identifies at least one of cell type and/or cell state of the cells (or the disease/health state of the subject with the disease state including the possibility of virus infection, or drug susceptibility of a subject to bacteria or fungus). The method may also be employed with biological entities or cellular structures such as exosomes and even protein or nucleic acid fragments to determine disease states or health states of the subject.

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

Abstract: Methods and systems for determining a radar compatible coating are provided. In one example, the method includes obtaining a reflectance measurement of a target coating to characterize a color of the target coating. One or more candidate formulas are generated to determine color matching to the color of the target coating. A corresponding color and a corresponding radar property for each of the one or more candidate formulations is predicted. A radar compatible coating composition that is the same or substantially similar in appearance to the target coating is generated. Generating the radar compatible coating composition is based at least in part on the corresponding color and the corresponding radar property for one of the one or more candidate formulations.

Abstract: A device for optical detection of analytes in a sample includes at least two optoelectronic components. The optoelectronic components include at least one optical detector configured to receive a photon and at least one optical emitter configured to emit a photon. The at least one optical emitter includes at least three optical emitters disposed in a flat, non-linear arrangement, and the at least one optical detector includes at least three optical detectors disposed in a flat, non-linear arrangement. The at least three optical emitters and the at least three optical detectors include at least three different wavelength characteristics.

Abstract: A system and related methods include a durable component, an indicator component including an indicator zone comprising at least one colorimetric analyte sensing element, at least one moisture sensor, and a fluid collection reservoir. The durable component contains at least one spectrophotometer, a computing system, and means for electronic communication between the computing system and at least one external device. The indicator component includes at least one colorimetric analyte sensing element and a fluid transport layer in fluid communication with the indicator zone, and it is arranged and configured for attachment to the durable component. In addition, the moisture sensor is arranged and configured to communicate the presence of moisture to initiate a predetermined delay in measuring the concentration of at least one analyte. The fluid collection reservoir is releasable from at least one of the indicator components and the durable component at a predetermined breaking point for clinical analysis.

Abstract: Optical sample characterization facilitates measurement and testing such as transmittance or reflectance at any discrete angle in a full range of angles of light propagation through a coated glass plate having a higher than air index of refraction. A rotatable assembly includes a cylinder having a hollow, and a receptacle including the hollow. The receptacle also contains a fluid having a refractive index matching the refractive index of the cylinder and coated plate. An optical light beam is input normal to the surface of the cylinder, travels through the cylinder, then via the index matching fluid through the coating, the coated glass plate, the fluid, the other side of the cylinder, and is collected for analysis. Due at least in part to the index matching fluid surrounding the coated plate, the plate can be rotated through a full range of angles (±90°, etc.) for full range testing of the coating.

Abstract: A device may receive information identifying results of a set of spectroscopic measurements of a training set of known samples and a validation set of known samples. The device may generate a classification model based on the information identifying the results of the set of spectroscopic measurements, wherein the classification model includes at least one class relating to a material of interest for a spectroscopic determination, and wherein the classification model includes a no-match class relating to at least one of at least one material that is not of interest or a baseline spectroscopic measurement. The device may receive information identifying a particular result of a particular spectroscopic measurement of an unknown sample. The device may determine whether the unknown sample is included in the no-match class using the classification model. The device may provide output indicating whether the unknown sample is included in the no-match class.

Abstract: In some implementations, a device may determine that an unknown sample is an outlier sample by using an aggregated classification model. The device may determine that one or more spectroscopic measurements are not performed accurately based on determining that the unknown sample is the outlier sample. The device may cause one or more actions based on determining the one or more spectroscopic measurements are not performed accurately.