Abstract: The present invention provides a heat shock protein immunotoxin comprising: at least a fragment of a heat shock protein, the fragment being capable of being bound by an immune cell; and a toxin bound to the fragment. The present invention also provides a method for decreasing the number of immune cells in an individual using the heat shock protein immunotoxins of the present invention. In addition, the present invention provides a method for decreasing the number of immune cells in an organ using the heat shock protein immunotoxins of the present invention.
Abstract: A method for reducing gastrointestinal inflammation in an animal is disclosed. The method involves administering to the animal an agent that reduces the bioavailability in the animal of a prostaglandin or leukotriene lipid precursor wherein the agent comprises an antibody.
Abstract: A compound of Formula (I):
wherein R is a linkage independently selected from (CH2)12 or (CH2)4O3; and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
Type:
Grant
Filed:
July 31, 2000
Date of Patent:
April 9, 2002
Assignee:
The University of Toledo
Inventors:
Walajapet G. Rajeswaran, William S. Messer
Abstract: Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a first portion which targets a desired cysteine protease and positions the inhibitor near the thiolate anion portion of the active site of the protease, and a second portion which covalently bonds to the cysteine protease and irreversibly deactivates that protease by providing a carbonyl or carbonyl-equivalent which is attacked by the thiolate anion of the active site of the cysteine protease to sequentially cleave a .beta.-dicarbonyl enol ether leaving group.
Type:
Grant
Filed:
February 2, 1998
Date of Patent:
November 14, 2000
Assignee:
Prototek, Inc.
Inventors:
Mary P. Zimmerman, Robert E. Smith, Mark Becker