Patents Examined by C. Kalita
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Patent number: 4452981Abstract: A condensed phenylurazol of the formula: ##STR1## wherein X is a chlorine atom or a bromine atom, Y and Z are each an oxygen atom or a sulfur atom and R is a C.sub.1 -C.sub.3 alkyl group, an allyl group or a propargyl group and n is an integer of 4 or 5, which is useful as a herbicide.Type: GrantFiled: September 15, 1982Date of Patent: June 5, 1984Assignee: Sumitomo Chemical Company, LimitedInventors: Eiki Nagano, Shunichi Hashimoto, Ryo Yoshida, Hiroshi Matsumoto, Katsuzo Kamoshita
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Patent number: 4450271Abstract: An improved procedure for the manufacture of 2-hydroxyquinoxalines from reacting a dialkyl tartrate with a periodate, adjusting the pH of the resulting reaction mixture, and condensing said mixture with an o-phenylenediamine.Type: GrantFiled: July 19, 1982Date of Patent: May 22, 1984Assignee: Industrial Technology Research InstituteInventors: Tsung-Tsan Su, Yu-Chen Cheng
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Patent number: 4450272Abstract: This disclosure describes 4-heteroaryl-1-piperazinethiocarboxamides useful in the treatment of atherosclerosis in mammals.Type: GrantFiled: May 6, 1982Date of Patent: May 22, 1984Assignee: American Cyanamid CompanyInventors: Mila T. Du, Robert G. Shepherd
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Patent number: 4447365Abstract: Described are the alkyl and bicycloalkyl methyl carbonates defined according to the structure: ##STR1## wherein R represents 2-ethyl hexyl, having the structure: ##STR2## or isobornyl having the structure: ##STR3## and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles.Type: GrantFiled: January 18, 1983Date of Patent: May 8, 1984Assignee: International Flavors & Fragrances Inc.Inventors: Richard M. Boden, Michael Licciardello, Theodore J. Tyszkiewicz
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Patent number: 4446323Abstract: Tetra- and hexa-hydropyrrolo[1,2-a]quinoxaline and azaquinoxaline derivatives of the formula: ##STR1## in which X is O or H.sub.2 ;Y is CH or N;R is hydrogen, alkyl, dialkylaminoalkyl, arylalkyl, phenoxyalkyl, benzoyl, pyridylalkyl or variations thereof; andR.sup.1 is hydrogen, alkyl, alkoxy, nitro, halo, trifluoromethyl, amino, alkylamino or dialkylamino;or pharmaceutically acceptable salts thereof; are anti-hypertensive agents.Type: GrantFiled: May 23, 1983Date of Patent: May 1, 1984Assignee: American Home Products CorporationInventors: Meier E. Freed, Magid Abou-Gharbia
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Patent number: 4442111Abstract: Compounds of the formula ##STR1## wherein n is 0 or 1;A is methylene, vinylene or ethylene optionally substituted by lower alkyl;B is alkylene;R.sub.1 is an optionally substituted alkyl, phenyl or naphthyl group, or a cycloalkyl or pyridyl group; andR.sub.2 is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics.Type: GrantFiled: July 6, 1982Date of Patent: April 10, 1984Assignee: Dr. Karl Thomae Gesellschaft mit beschrankter HaftungInventors: Erich Muller, Josef Nickl, Berthold Narr, Josef Roch, Walter Haarmann, Johannes M. Weisenberger
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Patent number: 4440930Abstract: Disclosed are certain herbicidally active quinoline or quinoxaline acetophenone oxime derivatives, herbicidal compositions containing these compounds and the use of such compounds to control the growth of noxious plants, i.e., weeds.Type: GrantFiled: October 25, 1982Date of Patent: April 3, 1984Assignee: PPG Industries, Inc.Inventors: Dennis K. Krass, Sidney B. Richter
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Patent number: 4439606Abstract: This disclosure describes 4-aryl, -heteroaryl and -heteroarylmethyl-1-piperazinecarbonyl compounds which are capable of ameliorating atherosclerosis in mammals.Type: GrantFiled: May 6, 1982Date of Patent: March 27, 1984Assignee: American Cyanamid CompanyInventors: Mila T. Du, Robert G. Shepherd
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Patent number: 4435331Abstract: Described is the methyl carbonate of .alpha.,3,3-trimethyl cyclohexane methanol defined according to the structure: ##STR1## and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles such as solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softeners, fabric softener articles as well as hair sprays, shampoos and bath oils and perfumed polymers. Also described is a process for preparing the methyl carbonate of .alpha.Type: GrantFiled: March 10, 1983Date of Patent: March 6, 1984Assignee: International Flavors & Fragrances Inc.Inventors: Michael Licciardello, Richard M. Boden
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Patent number: 4430502Abstract: The present invention provides novel pyridinyl-benzimidazoles and quinoxalines which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.Type: GrantFiled: August 13, 1982Date of Patent: February 7, 1984Assignee: The Upjohn CompanyInventor: Norman A. Nelson
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Patent number: 4426391Abstract: Novel prodrugs of methyldopa which are [(alkoxycarbonyl)oxy]alkyl esters of methyldopa are disclosed. Also, pharmaceutical compositions containing these compounds are disclosed. Upon administration to warm-blooded animals, these prodrugs liberate methyldopa along with innocuous side products.Type: GrantFiled: September 15, 1982Date of Patent: January 17, 1984Assignee: Merck & Co., Inc.Inventors: Jose Alexander, Chung Shih
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Patent number: 4426331Abstract: A process for the oxidative carbonylation of an alcohol to produce a carbonate, which comprises reacting together carbon monoxide, oxygen and an alcohol, in the presence of a copper compound and in the presence of a sulfone.Type: GrantFiled: July 19, 1982Date of Patent: January 17, 1984Assignee: Shell Oil CompanyInventor: Eit Drent
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Patent number: 4414389Abstract: The compounds ##STR1## where R is hydrogen, alkyl, phenyl or substituted phenyl and R.sup.1 is 2-furanyl, 2-benzofuranyl, 2-thienyl or 2-pyridyl or pharmaceutically acceptable salts thereof are antihypertensive, antisecretory agents.Type: GrantFiled: May 25, 1982Date of Patent: November 8, 1983Assignee: American Home Products CorporationInventor: Meier E. Freed
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Patent number: 4397789Abstract: Described are the 4-cyclooctenyl lower alkyl carbonates reaction products including a major proportion of said 4-cyclooctenyl alkyl carbonates and a minor proportion of bicyclooctanyl carbonates having the structure: ##STR1## wherein R.sub.5 is methyl or ethyl, said mixture being produced by: first reacting 1,5-cyclooctadiene with formic acid to form a mixture of 4-cyclooctenyl formate in a major proportion and bicyclooctanyl formate in a minor proportion and then reacting the resulting mixture with an alkyl carbonate in the presence of an alkali metal alkoxide to form a mixture of compounds defined above and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles such as solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softeners, fabric softener articles, hair sprays, shampoos, bath oils and perfumed polymers.Type: GrantFiled: August 19, 1982Date of Patent: August 9, 1983Assignee: International Flavors & Fragrances Inc.Inventors: Richard M. Boden, Michael Licciardello
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Patent number: 4395556Abstract: Nitrobenzofurazan derivatives having the formula ##STR1## are provided wherein R.sub.1 and R.sub.2 each is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkyl; R.sub.4 is hydrogen or lower alkyl; m is 2 or 3; and n is 0, 1 or 2; these compounds are useful analytical tools.Type: GrantFiled: February 4, 1982Date of Patent: July 26, 1983Assignee: E. R. Squibb & Sons, Inc.Inventors: Callixtus E. Ita, Anthony F. Heald, Peter Egli