Patents Examined by C. Koh
  • Collagen-based matrices ribose cross-linked
    Patent number: 4971954
    Abstract: Stabilized collagen-based matrices are prepared by non-enzymatic glycosylation of native collagen to irreversibly cross-link collagen polypeptide chains. The sugar cross-linking agents, preferably is D-ribose, provide non-immunogenic, non-toxic cross-linked collagen matrices especially useful in clinical and veterinary applications.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: November 20, 1990
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Barbara Brodsky, Richard A. Berg, Gad Avigad, Eric Eikenberry, Manoj Jain, Shizuko Tanaka