Patents Examined by C. L. Cseh
  • Patent number: 5010195
    Abstract: Alkoxy substituted 1,2,4-triazolo[1,5-c]-pyrimidine-2-sulfonamides are prepared from alkoxy substituted 1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonyl halides by condensation with substituted N-trialkylsilylanilines and by other methods. N-(2,6-dichloro-3-methylphenyl)-5,7-dimethoxy-1,2,4-triazolo[1,5-c]pyrimid ine-2-sulfonamide is typical. The compounds are general and selective pre- and postemergence herbicides.
    Type: Grant
    Filed: May 3, 1989
    Date of Patent: April 23, 1991
    Assignee: The Dow Chemical Company
    Inventors: John C. Van Heertum, Ben C. Gerwick, III, William A. Kleschick
  • Patent number: 4990624
    Abstract: Polyetherimide oligomers having crosslinking end cap moieties which provide improved solvent-resistance to cured composites are generally represented by the formula: ##STR1## wherein ##STR2## E=allyl or methallyl; R=a trivalent C.sub.(6-13) aromatic organic radical;R.sub.1 =any of lower alkyl, lower alkoxy, aryl, or substituted aryl;R'=a divalent C.sub.(6-30) aromatic organic radical;j=0, 1, or 2; andG=--CH.sub.2 --, --O--, --S--, or --SO.sub.2 --Blends generally comprise substantially equimolar amounts of the oligomers and a comparable, compatible, noncrosslinking, etherimide polymer of substantially the same backbone. The crosslinkable oligomers are made by reacting substituted phthalic anhydrides with hydroxyaryl amines and suitable crosslinking end cap reactants, or by self-condensation of phthalimide salts followed by capping of the polymers.
    Type: Grant
    Filed: June 30, 1988
    Date of Patent: February 5, 1991
    Assignee: The Boeing Company
    Inventors: Clyde H. Sheppard, Hyman R. Lubowitz
  • Patent number: 4988813
    Abstract: 2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl]pyrido[2,3,-d]pyrimid ines and 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimid ines are prepared through through the reaction of a haloaromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineoplastic agents.A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: January 29, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George S. K. Wong
  • Patent number: 4983749
    Abstract: A process for preparing a S-substituted phosphorochloridothiolate having the formula: ##STR1## wherein R.sup.1 is a chlorine atom or an alkoxy or phenoxy group which may be substituted, and R.sup.2 is an alkyl, alkenyl, alkynyl, cycloalkyl or phenyl group which may be substituted, which comprises isomerizing an O-substituted phosphorochloridothionate having the formula: ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, in the presence of a Lewis acid catalyst or a phosphorus compound catalyst.
    Type: Grant
    Filed: January 15, 1988
    Date of Patent: January 8, 1991
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Tasuhiro Tsujii, Tatsuo Isogai, Takao Awazu, Tokiya Kimura
  • Patent number: 4981976
    Abstract: Cyanatoaryl-substituted 1,6-diaza[4.4]spirodilactam having a cyanatoaryl-containing substituent on each spiro ring nitrogen atom self-cure upon application of heat to produce cured, crosslinked thermoset resins of high glass transition temperature.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: January 1, 1991
    Assignee: Shell Oil Company
    Inventor: Pen C. Wang
  • Patent number: 4981618
    Abstract: These compounds, represented by the formula (I) below, are used by way of agents inducing resistance to cryptogamic diseases in plants capable of being infested by a pathogenic fungus, for example, for the protection of wheat especially with respect to Septoria nodorum, Erysiphe graminis and Gaemannomyces graminis; of capsicum with respect to Phytophthora capsici; of melon with respect to Pseudoperonospora cubensis; of tomato with respect to Phytophthora infestans; and of "Xanthi" tobacco with respect to Phytophthora parasitica var. nicotianae. ##STR1## in which Z denotes the residues ##STR2## with 0.ltoreq.n1.ltoreq.15; 0.ltoreq.m1.ltoreq.15 and n1+m1=15; and CH.sub.3 --(CH.sub.2).sub.n2 --CH--(CH.sub.2).sub.m2 --, with 0.ltoreq.n2.ltoreq.18; 0.ltoreq.m2.ltoreq.18, and n2+m2=18.
    Type: Grant
    Filed: February 24, 1989
    Date of Patent: January 1, 1991
    Assignees: Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique
    Inventors: Maud Bruneteau, Paul-Michel Molot, Thadee Staron, Olivier Lhomme, Pierre Mas
  • Patent number: 4978382
    Abstract: A method of combating pests which comprises applying to such pests or to a pest habitat a pesticidally effective amount of a 2-halogenoalkylthio-substituted pyrimidine of the formula ##STR1## in which R.sup.1 represents halogenoalkyl,R represents hydrogen, alkyl, alkylthio, alkoxy, halogenoalkyl, halogenoalkylthio, halogenoalkoxy, optionally substituted aryl or halogen andm represents a number 0, 1, 2 or 3.Those compounds other than 2-(difluoromethylthiomethylthio)-4,6-dimethyl-pyrimidine, 2,4-bis(difluoromethylthio)-6-methylpyrimidine and 4-(difluoromethoxy)-2-(difluoromethylthio(-6-methylpyrimidine are new.
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: December 18, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Udo Kraatz, Ernst Kysela, Jurgen Hartwig, Benedikt Becker
  • Patent number: 4978688
    Abstract: A method of removing virus from white blood cells without causing concurrent damage to any red blood cells is provided by treating the white blood cells with an effective amount of a special detergent which selectively lyses the white blood cells without causing substantial lysis of any red blood cells in admixture therewith.
    Type: Grant
    Filed: March 24, 1989
    Date of Patent: December 18, 1990
    Inventor: Allan L. Louderback
  • Patent number: 4977190
    Abstract: Riboflavin produced by a microbial method is prepared in the form of free-flowing, non-dusting, spray-dried granules or microgranules as a feed additive by removing water from the mixture discharged from microbial fermentation for the preparation of riboflavin, wherein the mixture is subjected to(a) a fluidized-bed spray-drying process(b) a one-material spray-drying process or(c) a disk spray-drying process without significant amounts of binders being added to the discharged fermentation mixture.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: December 11, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Joachim Meyer, Wolfgang Buehler, Johannes Grimmer, Gunter Eipper, Hans Kiefer, Christoph Martin
  • Patent number: 4975468
    Abstract: A fluorocarbon microemulsion is provided which contains an ethoxylated alcohol as surfactant, the alcohol containing a tertiary carbon atom.
    Type: Grant
    Filed: April 3, 1989
    Date of Patent: December 4, 1990
    Assignee: Affinity Biotech, Inc.
    Inventor: Seang H. Yiv
  • Patent number: 4975465
    Abstract: A liquid water base ibuprofen composition for oral administration is described, the ibuprofen being maintained in suspension by a combination of primary suspending agents and being taste masked by primary taste masking agents, the composition also containing a buffer acid to adjust the pH of the composition to between 1.5 and up to about 3.5 and to provide a buffer capacity within the range of 0.03 to 0.05 between the initial pH and a pH which is 1.0 pH unit higher than the initial pH.
    Type: Grant
    Filed: March 28, 1989
    Date of Patent: December 4, 1990
    Assignee: American Home Products Corporation
    Inventors: Solomon Motola, Annabelle Mogavero, Gary R. Agisim, Pamela N. Panopoulos
  • Patent number: 4973685
    Abstract: Heteroannellated penicillins and cephalosporins of the formula ##STR1## in which R.sup.
    Type: Grant
    Filed: September 28, 1988
    Date of Patent: November 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Karl G. Metzger, Hans-Joachim Zeiler
  • Patent number: 4973709
    Abstract: Alkanolamines can be converted to a cyclic or a cyclic alkylamines and aziridines and/or other cyclic or acyclic alkanolamines by contacting the alkanolamines with a molecular sieve selected from the group consisting of (a) non-zeolitic molecular sieves; and (b) zeolites having a silicon:aluminum ratio of at least about 6, the contacting of the alkanolamine starting material with the molecular sieve being effected under conditions effective to convert the alkanolamine starting material into at least one of the specified products.
    Type: Grant
    Filed: December 18, 1987
    Date of Patent: November 27, 1990
    Assignee: Union Carbide Chemicals and Plastics Company, Inc.
    Inventors: Kurt D. Olson, Steven W. Kaiser
  • Patent number: 4966979
    Abstract: A novel process is described for preparing azetidine and 2 or 3 methyl and ethyl azetidine free bases by reacting primary arylmethylamine having suitable bulk providing substituents attached to the methyl carbon and an appropriate propane derivative having leaving groups in the one and three position in hot organic solvent containing a non-nucleophilic base and an amount of water sufficient to promote azetidine ring formation to give N-protected-azetidines and deprotecting by hydrogenolysis under acidic conditions to give an acid salt of the azetidines and thereafter flashing off vaporized azetidine from a hot, agitated strong base solution or slurry and condensing to give the liquid azetidine free bases.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: October 30, 1990
    Assignee: A. H. Robins Company, Incorporated
    Inventors: Young S. Lo, Dwight A. Shamblee, David H. Causey, Richard P. Mays
  • Patent number: 4966980
    Abstract: A process for producing an aziridine compound represented by the following general formula ##STR1## wherein R represents hydrogen, or a methyl or ethyl group, which comprises intramolecularly dehydrating an alkanolamine represented by the following formula ##STR2## wherein R is as defined, X is OH or NH.sub.2, and Y is NH.sub.2 when X is OH, and OH when X is NH.sub.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: October 30, 1990
    Assignee: Nippon Shokubai Kagaku Kogyo Co. Ltd.
    Inventors: Teruo Kamei, Yuuji Shimasaki, Hideaki Tsuneki, Koichi Yamamoto, Yutaka Morimoto, Michio Ueshima
  • Patent number: 4960919
    Abstract: A process for the preparation of alkyl esters of alkenylphosphinic acid, having the general formula I ##STR1## wherein R.sup.1 represents H or CH.sub.3, R.sup.2 alkyl having from 1 to 4 carbon atoms or phenyl and R.sup.3 alkyl having from 1 to 8 carbon atoms, which comprises cleaving an alkyl ester of 2-acetoxyethyl phosphinic acid, having the general formula II ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the meaning indicated above, in contact with a liquid catalytically acting medium and at a partial pressure of the total of the components of the reaction system in the range of from 1 to 500 mbar, and drawing off the resulting alkyl esters of alkenyl phosphinic acid and other volatile reaction products.The invention also relates to compounds of the formula I ##STR3## wherein (a) R.sup.1 represents H, R.sup.2 represents alkyl having from 1 to 4 carbon atoms or phenyl and R.sup.3 represents isobutyl or alkyl having from 5 to 8 carbon atoms, or(b) R.sup.1 represents CH.sub.3, R.sup.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: October 2, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Jerg Kleiner, Gunter Roscher
  • Patent number: 4959473
    Abstract: N-(Substituted-phenyl)-7-ethoxy-5-fluoromethyl-1,2,4-triazolo[1,5-a]pyrimid ine-2-sulfonamides are prepared from 2-benzylthio-5-fluoromethyl-1,2,4-triazolo[1,5-a]pyrimidines and found to be herbicidal. The compounds, illustrated by 7-ethoxy-5-fluoromethyl-(2,6-dichloro-3-methylphenyl)-1,2,4-triazolo[1,5-a ]pyrimidine-2-sulfonamide, are degradable in the soil and are selective to wheat.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: September 25, 1990
    Assignee: The Dow Chemical Company
    Inventors: Norman R. Pearson, William A. Kleschick, Chrislyn M. Carson
  • Patent number: 4958031
    Abstract: Polyetherimide oligomers having crosslinking end cap moieites which provide improved solvent-resistance to cured composites are generally represented by the formula: ##STR1## wherein X=--O--or --S--; ##STR2## n=1 or 2; E=allyl or methallyl;R=a trivalent C.sub.(6-13) aromatic organic radical;R.sub.1 =any of lower alkyl, lower alkoxy, aryl, or substituted aryl;R'=a divalent C.sub.(6-30) aromatic organic radical;j=0, 1, or 2; andG=--CH.sub.2 --, --O--, --S--, or --SO.sub.2 --The crosslinkable oligomers are made by reacting substituted phthalic anhydrides with hydroxyaryl amines and suitable crosslinking and cap reactants, or by self-condensation of phthalimide salts followed by capping the polymers.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: September 18, 1990
    Assignee: The Boeing Company
    Inventors: Clyde H. Sheppard, Hyman R. Lubowitz
  • Patent number: 4957931
    Abstract: Disclosed are 1,2-benzisoxazole and 1,2-benzisothiazole derivatives represented by formula I ##STR1## wherein X represents oxygen or sulfur; Z represents carbon (CH) so as to complete the imidazol-1-yl ring radical or Z represents nitrogen (N) so as to complete the 1,2,4-triazol-l-yl ring radical; R.sub.1 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; R.sub.2 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; or R.sub.1 and R.sub.2 combined represent lower alkylene; or R.sub.1 combined with R.sub.5 located on the Z-carbon atom of the imidazolyl radical represents C.sub.2 -C.sub.4 -alkylene; R.sub.3 and R.sub.4 independently represent hydrogen, lower alkyl, cycloalkyl, halogen, trifluoromethyl, cyano, nitro, amino, hydroxy, lower alkanoyloxy, carbocyclic aroyloxy, lower alkoxy, or carbocyclic aryl; or R.sub.3 and R.sub.4, together when located on adjacent carbon atoms, represent lower alkylenedioxy; or R.sub.3 and R.sub.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: September 18, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Robert M. Bowman
  • Patent number: 4956359
    Abstract: Novel 3-aryloxy and 3-arylthioazetidinecarboxamides having utility in a method of treating convulsions and epilepsy and compositions therefor are disclosed having the formula: ##STR1## wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo-substituted-pyridyl, phenyl or substituted phenyl; R.sup.1 and R.sup.2 are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl, diloweralkylaminoloweralkyl, and R.sup.1 and R.sup.2 when taken with the adjacent nitrogen atom may form a heterocyclic radical; R.sup.3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof, excepting that when R.sup.3 is hydrogen, Z is oxygen, B is oxygen, and Ar is phenyl or phenyl substituted by trifluoromethyl or aminocarbonyl, then R.sup.1 and R.sup.2 cannot be a combination of hydrogen and loweralkyl, and the further exception that when R.sup.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: September 11, 1990
    Assignee: A. H. Robins Company, Inc.
    Inventors: Chandler R. Taylor, Jr., Albert D. Cale, Jr., Harold F. Stauffer, Jr.