Abstract: Mixing apparatus having a sealed impeller shaft provided by a seal unit which supports the shaft and to which a motor drive unit may be detachably connected. When the motor drive unit is disconnected, the mixing apparatus may be sterilized, along or together with the vessel containing the material to be mixed and to which the seal unit is attached. The seal unit has a seal assembly with a movable part engageable by a drive shaft in the drive unit when the drive unit is mounted on the seal unit. The movable seal part is biased to move to a position against a mounting plate on which the drive unit is mounted when the drive mounted is removed so as to provide a static seal. When the drive unit is attached to the seal unit, the driven shaft engages the moveable seal unit part and moves it to another position away from the mounting plate, where the seal assembly may freely rotate with the impeller shaft and maintain a dynamic seal.