Abstract: The present invention provides a method for producing a peptide for the treatment (in particular, immunotherapy), monitoring, or diagnosis of a disease in a subject. This method is achieved by obtaining information pertaining to a genome read, for example an exome read, of the subject and a mutation thereof, and, as necessary, information regarding the RNA sequence of the subject and information regarding the MHC type of the subject, analyzing an epitope related to the mutation on the basis of the information pertaining to the genome read (for example, the exome read) and the mutation, arbitrary information from the RNA sequence, the MHC type information, and information regarding the disease, and producing a peptide, as necessary, on the basis of information regarding the epitope.

Abstract: Techniques are described and relate to anisotropic pooling for contextual embedding of a protein sequence. In an example, a system receives a first biological sequence and determines a sequence arrangement that comprises a component of the first biological sequence and a second biological sequence of components. By using an artificial intelligence (AI) model, the system determines a third sequence that comprises a contextual embedding vector corresponding to the component of the first biological sequence. The AI model generates the third sequence based at least in part on the sequence arrangement and by at least using a convolution and anisotropic pooling.

Abstract: Embodiments for storing digital data in DNA storage by receiving input file data, encoding the input file data into an oligonucleotide sequence to produce sequence data through a transformation of text to binary to Base_3 encoding, organizing the Base_3 sequence data into chunks of a defined chunk size, and storing the chunks in a block of a blockchain. The oligonucleotide sequence may comprise metadata for the input file data that refers to actual data stored in the DNA storage, where the actual data is formed by synthesizing the oligonucleotide sequence in a DNA synthesis process. The chunks may be stored in the blockchain only if the block agrees with a smart contract defined for the oligonucleotide sequence.

Abstract: A tool for winding and unwinding for a line-strainer, which has a housing to enclose and secure the strainer during winding and unwinding and provides a mechanism for applying an approximately directed transverse load to the line, such as wire, during the winding or unwinding modes to direct the wire onto or off the strainer hub.

Abstract: An open-face fishing reel of the fixed-spool type has a rotor, a line spool, a bail for winding a line onto the line spool, and a detachable trigger mechanism. Two mounting elements supporting the bail are so rotatably mounted each on one attachment on the rotor that the bail is pivotal between a folded-in line-winding position and a folded-out position in which it is released of the line. The trigger mechanism has a support element releasably mounted on one of the attachments and carrying a pin on which a trigger is mounted for pivotal movement between a first position and a second position. A driver eccentrically engages the mounting element mounted on the above-mentioned attachment.