Abstract: A method of sensing a target material in an environment is disclosed. The method comprises exposing a sensor to an environment for a first exposure period. The method further comprises, following the first exposure period, isolating the sensor from any target material in the environment for a first isolation period wherein the first isolation period is less than a characteristic recovery period for the sensor to return to a baseline after the first exposure period. The method further comprises, following the first isolation period, exposing the sensor to the environment for a second exposure period, and determining a concentration of the target material from a response of the sensor during the second exposure or a response of the sensor during the first and second exposure.

Abstract: The invention relates to a method for operating a fluidic microsystem (100) for the dielectrophoretic manipulation of suspended particles (1) having a particle diameter in a suspension liquid (2), wherein the microsystem (100) comprises: —a channel (10) having a longitudinal direction; —an electrode device (20) having an electrode (21), the longitudinal extent of which deviates from the longitudinal direction of the channel (10) and which has individually controllable electrode segments (22) for producing dielectrophoretic forces which act on the particles (1), each electrode segment (22) having a deflection angle ?, relative to the longitudinal direction of the channel (10), and a segment length (si), which determine a segment offset (Di) perpendicular to the longitudinal direction of the channel (10); and —a control device (30).

Abstract: A signal is obtained which comprises voltage measurements obtained from the calibration fluid and voltage measurements obtained from the unknown fluid. Diffusion of the measurements during the transition from measuring the calibration fluid to measuring the unknown fluid is modelled using a first model. The drift of the measurements is modelled from the calibration fluid measurements using a second model. The first model identifies a value and corresponding time point at which the diffusion process has settled. A calibration voltage value is estimated at the corresponding time point and the difference between the identified value and the calibration electrical potential value is calculated to determine a voltage difference. This voltage difference is normalized by adjusting the difference by a shift amount determined in relation to the calibration electrical potential value and a predetermined voltage value. The normalized voltage is then used to determine the ion concentration of the unknown fluid.

Abstract: A pattern electrode structure for an electrowetting device is laminated between a base material and a dielectric layer of the electrowetting device, and the pattern electrode structure includes first branch electrodes formed in a direction perpendicular to any plane perpendicular to a plane defined by the pattern electrode structure, and a basal pattern electrode formed in an area below lower ends of the first branch electrodes and connected to an electrode connection portion configured to receive a voltage, in which a sum of an interval between the first branch electrode and the basal pattern electrode and a width of the basal pattern electrode is larger than a diameter of a droplet to be removed, thereby preventing the droplet from stagnating without falling at the terminal end of the pattern in a structure that uses the vertical pattern.

Abstract: The present disclosure provides a sensing assembly for sensing an analyte. The sensing assembly comprises multiple test electrodes configured to provide signals from multiple independent measurements in response to the analyte. Alternatively or additionally, the multiple test electrodes are configured to produce different transient responses in response to a given concentration of the analyte.

Abstract: A method for recovering a biological substance and a device for recovering a biological substance capable of improving a recovery rate of a target biological substance with a simple configuration are provided. The method for recovering a biological substance uses an electrophoresis device having a gel 13 and recovery holes 11 and 111. The method for recovering a biological substance includes a step of starting application of a voltage for moving a target biological substance toward the recovery hole, after that, a step of removing buffer solution in the recovery hole before the target biological substance reaches the recovery hole, after that, a step of injecting a solvent into the recovery hole, and, after that, a step of recovering the target biological substance that reaches the recovery hole.

Abstract: A carbon monoxide gas sensor is a single-chamber sensor for measuring the carbon monoxide gas concentration in a gas phase. The carbon monoxide gas sensor has electrodes disposed on respective sides of a solid electrolyte layer. One of the electrodes is active for oxidation of carbon monoxide gas, and the other of the electrodes is more inactive for oxidation of carbon monoxide gas than the one electrode. The carbon monoxide gas sensor is configured to measure a short-circuit current between the electrodes. In the carbon monoxide gas sensor, the solid electrolyte layer has oxide ion conductivity.

Abstract: Embodiments relate to a biosensor. The biosensor includes an electrochemical system having a generator electrode, a collector electrode, and electrolyte. The generator electrode includes a particle capture region having an aspect ratio that is greater than 1. The particle capture region is a portion of the generator electrode configured to attract a particle supported within the electrolyte. The electrochemical system is operated so as to bias one of the generator electrode or the collector electrode below its formal potential while biasing the other electrode above its formal potential. The biosensor includes a processing module configured to measure electric current generated by the electrochemical system.

Abstract: The present disclosure provides sensor assemblies comprising a plurality of mixing species provided adjacent or on the sensing surface, wherein each mixing species comprises a polynucleotide chain and wherein each mixing species is anchored to the sensor assembly; and an actuation unit configured to move at least a part of each mixing species in a plurality of directions. Alternatively or additionally, the polynucleotide chain comprises DNA and has a length of at least 10 nm.

Abstract: A sensor includes: a support substrate; at least one surface structure protruding from an upper surface of the support substrate, wherein the surface structure includes an electrode layer; a sensing surface on the electrode layer, wherein the sensing surface is adapted to contact a sample containing a target analyte; a binding region on the support substrate, wherein the binding region is separated from the sensing surface; wherein, in use, a binding agent attached to a binding layer at the binding region is also adapted to contact the sample containing the target analyte.

Abstract: Some embodiments described herein relate to capillary-containing cartridges suitable for use with capillary electrophoresis instruments. Embodiments described herein generally relate to cartridges that include a transfer capillary coupled to a separation capillary. The transfer capillary can be configured to be disposed in sample reservoirs and/or buffer reservoirs. Suction applied through a sheath interface of the transfer capillary and the separation capillary can draw sample/buffer from such reservoirs and bring the sample/buffer into contact with the separation capillary. The separation capillary can be configured for separation of analytes contained within the sample, for example when an electric potential (i.e., voltage) is applied across the separation capillary.

Abstract: Provided are a sample analysis method comprising: separating hemoglobin in a sample from the sample comprising the hemoglobin, in an alkaline solution by capillary electrophoresis, wherein the alkaline solution comprises a cationic polymer having a secondary amino group and a quaternary ammonium base.

Abstract: A soft and stretchable microelectrode array (sMEA) including a first circuit board having a first though hole; a second circuit board having a second through hole; a microelectrode array including a plurality of microelectrodes embedded in an elastomeric substrate, wherein the microelectrode array is disposed between the first and second printed circuit boards, and includes an exposed portion corresponding the first and second through holes; a plurality of contact pads formed on a top or bottom surface of the first printed circuit board and electrically connected to the plurality of microelectrodes; and a culture well mounted on the first printed circuit board and encompassing the first through hole. Further, the exposed portion of the microelectrode array includes a 3D pocket lined with stretched microelectrodes for electrically stimulating and recording signals from an organoid placed in the 3D pocket.

Abstract: A dopamine (DA) sensor includes a glassy carbon electrode including an indium oxide doped zinc oxide (In2O3-doped ZnO) decorated mesoporous carbon (In2O3·ZnO@MC) nanocomposite material. The In2O3·ZnO@MC includes aggregates of spherical In2O3 nanoparticles (NPs) and cubic ZnO NPs dispersed on the surface of the mesoporous carbon.

Abstract: An electrochemical sensor comprising an array of working electrodes made of noble metals, wherein the array includes: one or more bare working electrode(s); and a first set of working electrodes coated with a first transition metal dichalcogenide, the first set comprises at least subset A and subset B, wherein working electrodes of subset B show the presence of hydroxide form(s) and/or high oxidation state oxide forms(s) of the noble metal, whereas working electrodes of subset A are free of such forms; and/or working electrodes of subset B show higher capacitive currents and lower charge transfer resistance compared to working electrodes of subset A, as determined by electrochemical impedance spectroscopy.

Abstract: A method for manufacturing a gas sensor element (100) including a solid electrolyte (110) and an electrode (130) formed on a surface (110a) of the solid electrolyte (110). The method includes: a slurry application step S3 of forming a first slurry layer (13) by applying a first slurry containing monoclinic zirconia and tetragonal/cubic zirconia to the surface (110a) of the solid electrolyte (110); a heat treatment step S4 of forming a base layer (14) by a heat treating the solid electrolyte (110) having the first slurry layer (13) formed thereon; and a plating step S5 of forming the electrode (130) by plating the base layer (14) using a plating solution containing a noble metal.

Abstract: The present disclosure relates to a method of distinguishably detecting two biomarkers with cross-reactivity in a biological sample. The method comprises providing two sensor units specific to the two biomarkers, respectively; obtaining binding affinities of a series of known concentrations of the two biomarkers to the sensor units, respectively; contacting the biological sample with the two sensor units to produce two signals; and calculating the concentrations of the two biomarkers in the biological sample with the two signals and the binding affinities.

Abstract: The disclosure relates to methods of analyzing a post-translationally modified protein of interest using electrophoresis, the methods comprising deglycosylating the protein of interest after labeling.

Abstract: A solid electrolyte assembly includes a substrate, a solid electrolyte, and a first electrode and a second electrode. The solid electrolyte has oxide ion conductivity, and the first electrode is located under the solid electrolyte and contains a porous material. The first electrode has only one oxygen diffusion path that is formed overlapping the substrate and the solid electrolyte. When Sr represents the smallest cross-sectional area that is a cross-sectional area of the oxygen diffusion path at a location where the area of a cross section of the first electrode taken perpendicularly to an oxygen diffusing direction is smallest in a portion of the oxygen diffusion path where the oxygen diffusion path overlaps the substrate and the solid electrolyte in a plan view of the solid electrolyte assembly, and Sp represents the area of a region where the first electrode and the second electrode overlap each other in a plan view of the solid electrolyte, Sr/Sp is from 1×10?7 to 6.9×10?4.

Abstract: The present disclosure relates to a device, system and method for sensing functional motions of a single protein molecule via direct attachment of one or more electrodes to the molecule. The present disclosure also relates to an array, a system comprising an array and method for sequencing a biopolymer using an array.