Patents Examined by C. Warren Ivy
  • Patent number: 5723622
    Abstract: A synthetic method for making pyridin-propyl-sulphobetaine, without any risks for the human beings and the environment is described. It comprises reacting a pyridine substituted alkyldihalogenide and then sulphonating in water with an alkylhalogenide solvent, so as to provide pyridin-propyl-sulphobetaine which can be separated from water leaving therein water the halogenides.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: March 3, 1998
    Inventors: Giuseppe Faranda, Luciano Antonio Vailati, Claudio Valzesi, Enrico Borroni
  • Patent number: 5721249
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • Patent number: 5721292
    Abstract: Compounds of formula (I), in which X is oxygen or sulfur, R.sub.1, R.sub.2 and R.sub.3 independently of one another are a group (a), C.sub.2 -C.sub.8 alkenyl, phenyl which is unsubstituted or is substituted from one to four times with C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy, C.sub.1 -C.sub.6 alkylthio and/or halogen, or are naphthyl which is unsubstituted or is substituted from one to four times with C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy, C.sub.1 -C.sub.6 alkylthio and/or halogen, or are biphenyl which is unsubstituted or is substituted from one to four times with C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy, C.sub.1 -C.sub.6 -alkylthio and/or halogen, or R.sub.1, R.sub.2 and R.sub.3 independently of one another are an O-, S- or N-containing 5- or 6-membered heterocyclic ring, R.sub.1 is in addition a group of formula (II), or R.sub.1 and R.sub.2 are linked to form a ring containing 4 to 10 carbon atoms which is unsubstituted or substituted by 1 to 6 C.sub.1 -C.sub.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: February 24, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: David George Leppard, Manfred Kohler, Gebhard Hug
  • Patent number: 5721255
    Abstract: The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R.sup.1, R.sup.2, R.sup.3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: February 24, 1998
    Assignee: Pfizer Inc.
    Inventors: Harry R. Howard, Masami Nakane, Masaya Ikunaka, Kunio Satake, Terry J. Rosen, John A. Lowe, III, Brian T. O'Neill, Fumitaka Ito
  • Patent number: 5721103
    Abstract: Novel trienoic compounds having activity for retinoic acid receptors and retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their use.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Marcus F. Boehm, Lin Zhang, Youssef L. Bennani, Alex M. Nadzan
  • Patent number: 5721275
    Abstract: Staple, aqueous gel vehicles are provided for the topical application to the skin of irritating active ingredients such as retinoids, particularly tretinoin, with slow release of the active ingredient and minimal irritancy to the skin. The vehicles include a gelling agent effective to form a gel and hold the active ingredient in the aqueous medium for slow release on the skin, and an effective amount of an antioxidant to retard decomposition of the active ingredient. The vehicles and formulations are preferably aqueous emulsions which contain a solubilizing agent for the generally non-water soluble active ingredients, as well as usually an emulsifying agent and/or surfactant. Chelating agents, emollients, preservatives and other adjuvants and additives may also be included in the vehicles and formulations.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: February 24, 1998
    Inventor: Gail S. Bazzano
  • Patent number: 5719303
    Abstract: A phosphonic acid derivative which is useful for medically treating hyperlipemia, represented by the following general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## Representative example of the compound according to the present invention is one represented by the following formula: ##STR2##
    Type: Grant
    Filed: September 6, 1995
    Date of Patent: February 17, 1998
    Assignee: Eisai Co., Ltd.
    Inventors: Ichirou Yoshida, Hironori Ikuta, Yoshio Fukuda, Yoshihito Eguchi, Makoto Kaino, Katsuya Tagami, Naoki Kobayashi, Kenji Hayashi, Hironobu Hiyoshi, Issei Ohtsuka, Makoto Nakagawa, Shinya Abe, Shigeru Souda
  • Patent number: 5717094
    Abstract: A process is disclosed for the preparation of disubstituted acetylene derivatives having retinoic acid like biological activity, wherein 6-ethynyl-chroman, 6-ethynyl-thio chroman and 6-ethynyl-1,2,3,4-tetrahydroquinoline derivatives of the formula shown below are reacted in the presence catalysts with halogenated phenyl or heteroaryl derivatives of to provide the disubstituted acetylenes.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: February 10, 1998
    Assignee: Allergan
    Inventor: Roshantha A. S. Chandraratna
  • Patent number: 5717100
    Abstract: Compounds represented by formula I: ##STR1## are disclosed. AR represents an aromatic group containing 6-10 atoms; and ##STR2## represents a 4 to 6 membered non-aromatic heterocycle containing only one N atom.A pharmaceutical composition is also included.Methods of treating cancer and cytokine mediated diseases are also included.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: February 10, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Harold G. Selnick, David A. Claremon, Nigel J. Liverton
  • Patent number: 5716983
    Abstract: Use of compounds of formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, Y and Z have the meanings stated in the claims, tautomers thereof as well as their salts with non-toxic acids or bases for the production of pharmaceutical agents having an inhibitory action on PLA.sub.2 in addition to compounds of formula I in which X does not denote a valency and processes for the production thereof.
    Type: Grant
    Filed: March 14, 1996
    Date of Patent: February 10, 1998
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Wolfgang Schaefer, Werner Scheuer, Ulrich Tibes
  • Patent number: 5716967
    Abstract: This invention relates to isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDE.sub.IV). The isoxazoline compounds are useful in inhibiting PDE.sub.IV and in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease, psoriasis, allergic rhinitis, dermatitis, shock, atopic dermatitis, rheumatoid arthritis and osteoarthritis. This invention also relates to pharmaceutical compositions useful therefor.
    Type: Grant
    Filed: May 15, 1996
    Date of Patent: February 10, 1998
    Assignee: Pfizer Inc.
    Inventor: Edward Fox Kleinman
  • Patent number: 5714650
    Abstract: A process is disclosed for producing 1,1-difluoroethane (HFC-152a) in a liquid phase by contacting chloroethene and hydrogen fluoride in the presence of a tin tetrahalide catalyst. The ability to reduce tar formation and increase volumetric productivity is also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 3, 1998
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Klaus Guenter Wuttke
  • Patent number: 5714639
    Abstract: Improved double metal cyanide (DMC) catalysts useful for making epoxide polymers are disclosed. One catalyst is a paste of a double metal cyanide (DMC) compound, an organic complexing agent, and water. The paste comprises at least about 90 wt. % of particles having a particle size within the range of about 0.1 to about 10 microns as measured by light scattering in polyether polyol dispersions of the catalyst particles. Preferred catalysts have a bimodal particle size distribution. The paste catalyst is more active and simpler to prepare than powder DMC catalysts. Polyols made from the paste catalyst have low unsaturations, low viscosities, and narrow molecular weight distributions, and are useful in making a variety of polyurethane products.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: February 3, 1998
    Assignee: Arco Chemical Technology, L.P.
    Inventors: Paul T. Bowman, Harry R. Hinney, Robert L. Meeker
  • Patent number: 5714495
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined in the description and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: February 3, 1998
    Assignee: Adir et Compagnie
    Inventors: Marie-Claude Viaud, Gerald Guillaumet, Daniel Mazeas, Herve Vandepoel, Pierre Renard, Bruno Pfeiffer, Philippe Delagrange
  • Patent number: 5714613
    Abstract: A method of producing a 2-naphthamide derivative of formula (I) that can be employed as an antiallergic agent or an agent for curing allergosis, and compounds for producing the 2-naphthamide derivative are provided: ##STR1## wherein R.sup.1 and R.sup.2 are each independently an unsubstituted or substituted aromatic hydrocarbon group, or an unsubstituted or substituted aromatic heterocyclic group; R.sup.3 is an acyl group, an alkoxylcarbonyl group, a substituted carbamoyl group, or an unsubstituted or substituted alkyl group.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: February 3, 1998
    Assignee: Fujirebio Inc.
    Inventors: Hiroshi Ikawa, Masato Nishimura
  • Patent number: 5714610
    Abstract: In a process for preparing 3-methylpiperidine or 3-methylpyridine from 2-methyl-1,5-diaminopentane in the gaseous phase, the initial product is made to flow over catalysts. In the first step, 3-methylpiperidine is produced, and if required 3-methylpyridine is produced in a second step.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: February 3, 1998
    Assignee: Lonza Ltd.
    Inventors: Josef Heveling, Erich Armbruster, Walter Siegrist
  • Patent number: 5714611
    Abstract: N,N'-bridged bistetramethylpiperidinyl compounds of Formula I ##STR1## useful as light stabilizers and stabilizers for organic material which are prepared starting from tetramethylpiperidinyl compounds of Formula II ##STR2## by reacting a compound of Formula II with a cyclic carbonate of Formula III.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: February 3, 1998
    Assignee: BASF Aktiengesellschaft
    Inventor: Alexander Aumuller
  • Patent number: 5714499
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: February 3, 1998
    Assignee: Corvas International, Inc.
    Inventors: Joseph E. Semple, Odile E. Levy, Ruth F. Nutt, William C. Ripka
  • Patent number: 5714645
    Abstract: An all trans-form polyprenol is obtained by;(A) subjecting a 3,7-dimethyl-6-hydroxy-7-octen-1-ol derivative to five-carbon lengthening reaction m-times which comprises reacting with 2-methyl-3,3-dimethoxy-1-butene and reducing the carbonyl group of the resulting compound, to obtain an allyl alcohol derivative;(B) halogenating the hydroxyl group of the allyl alcohol derivative to convert it to form an allyl halide derivative;(C) allowing the allyl halide derivative to react with a polyisoprenyl sulfone derivative to form a sulfonated polyprenol derivative; and(D) subjecting the sulfonated polyprenol derivative to desulfonylation to obtain the all trans-form polyprenol.
    Type: Grant
    Filed: October 29, 1996
    Date of Patent: February 3, 1998
    Assignee: Kuraray Co., Ltd.
    Inventors: Goro Asanuma, Yoshin Tamai, Koichi Kanehira
  • Patent number: 5714655
    Abstract: 2,2,3-trichloro-1,1,1,3,3-pentafluoropropane is used as a raw material, to which not less than 4.5 equivalent parts of hydrogen are added to effect a hydrogenation reaction in the presence of a noble metal catalyst, particularly a palladium catalyst, by the vapor phase method to manufacture 1,1,1,3,3-pentafluoropropane. Further, propane, propene, and hexachloropropene, etc. are chlorofluorinated in the presence of a metal catalyst to produce 2,2,3-trichloro-1,1,1,3,3-pentafluoropropane, then this compound is reduced with hydrogen in the presence of a noble metal catalyst to produce 1,1,1,3,3-pentafluoropropane. 2,2,3-trichloro-1,1,1,3,3-pentafluoropropane and 1,1,1,3,3-pentafluoropropane can thus be efficiently and economically produced.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: February 3, 1998
    Assignee: Daikin Industries, Ltd.
    Inventors: Akinori Yamamoto, Eiji Seki, Hirokazu Aoyama, Seiji Takubo, Tatsuo Nakada