Abstract: Analyte sensors and methods for fabricating analyte sensors and analyte sensing layers are presented here. In accordance with certain embodiments, a method for fabricating an analyte sensor includes providing a base layer and forming a conductive layer over the base layer. Further, the method includes forming an analyte sensing layer disposed over the conductive layer. The analyte sensing layer includes glucose oxidase entrapped within a thermally-cured polymer matrix and within a UV-cured polymer matrix.

Abstract: A cap for use with devices, such as sensors. The cap includes protrusions on its underside, to restrict the movement of a liquid or a gel placed under cap. The protrusions may take the form of walls or pillars, depending on the application. As such, the cap retains the liquid or gel in a specified position on the device. For example, an electrochemical sensor may require a liquid electrolyte to remain in place over one or more electrodes. The protrusions may not extend far enough to touch the device, but rather leave a small gap. However, because of the surface tension of the liquid, the liquid generally stays within the protrusions.

Abstract: A PCB based electrochemical sensor includes a PCB having a first electrode on a first surface of the PCB, and a second electrode on a second surface. A sensing element, such as a conductive wire, is attached to the first electrode. The PCB includes one or more through holes, and the conductive wire is positioned proximate one or more of the one or more through holes. When the PCB based electrochemical sensor is positioned in a solution to be sensed, the solution fills the through holes. The ions within the solution provide a current pathway between the conductive wire and the second electrode through the through holes. A voltage potential between the two electrodes is measured. The measured voltage potential is used to determine a value associated with the solution, such as a pH value.

Abstract: Provided is a gas sensor achieving improvement in detection accuracy for a specific gas component and responsiveness for detecting the specific gas component. A guide body is provided at a base end section of a first inner circulation hole in an inner cover of the gas sensor. The base end section is located between a base end position P1 2 mm away from a tip end of a sensor element in an axial direction L towards a base end side L1 and a tip end position P2 2 mm away from the tip end towards a tip end side L2. The tip end is on the base end side L1 relative to an imaginary line K passing through a base end and a tip end on a surface on the tip end side of the guide body.

Abstract: Apparatus and associated methods relate to a micro-electro-mechanical system (MEMS) based gas sensor including an electrolyte contacting one or more top electrode(s) arranged on the bottom surface of a top semiconductor substrate (TSS), and one or more bottom electrode(s) arranged on the top of a bottom semiconductor substrate (BSS), the TSS and BSS joined with an adhesive seal around the electrolyte, the sensor including one or more capillaries providing gaseous communication to the electrolyte from an external ambient environment. The electrodes may be electrically accessed by one or more vias to externally accessible bond pads. In some examples, an electrical connection may be made from an additional bond pad on top of the TSS to the electrolyte. Various embodiments may reduce the size of various gas sensors to advantageously allow their inclusion into portable electronic devices.

Abstract: A gas sensor element includes: an element main body including an oxygen concentration detection cell and an oxygen pump cell; and a protective layer that covers the element main body. The element main body includes a heater section. The heater section is a heating element that heats the oxygen concentration detection cell and the oxygen pump cell. The protective layer includes: a first protective layer including a carrier composed mainly of a white ceramic and a noble metal catalyst supported on the carrier; and a second protective layer that is a layer composed mainly of a white ceramic and supporting no noble metal catalyst. The second protective layer externally covers the first protective layer, and a surface of the second protective layer serves as the outermost surface of the protective layer. The thickness of the second protective layer is smaller than the thickness of the first protective layer.

Abstract: An object of the present invention is to solve inhibition of biopolymer measurement in a nanopore, which involves three-dimensional conformation of a biopolymer containing a nucleic acid. The present invention provides a device for analyzing a biopolymer containing a nucleic acid, the device including: an array device including a plurality of thin film parts having a nanopore; a single common container and a plurality of individual containers capable of storing a measurement solution which is brought into contact with the thin films; and individual electrodes respectively provided in the plurality of individual containers, wherein: the measurement solution is introduced into each of the individual containers and the common container so as to be brought into contact with the thin films; and the measurement solution has a pH equal to or greater than pKa of a guanine base and contains cesium ions as electrolyte cations.

Abstract: Disclosed is a gas sensor for detecting a measurement target gas in a measurement gas atmosphere, including: a first sensor element; a first installation part defining a first inner space in which the first sensor element is installed; and a casing accommodating therein the first installation part. The casing has an opening formed to introduce the measurement target gas into an inside of the casing. The first installation part has: a first gas introduction hole formed to provide communication between the first inner space and the inside of the casing; and a membrane member arranged to cover the first gas introduction hole and having permeability to water vapor and substantially no permeability to the measurement target gas. At least a portion of the first installation part in contact with the membrane member is made of insulating ceramic material or resin material.

Abstract: A sensor device, such as a biosensor, may comprise a polymer substrate, which is structured so as to form sets of microneedles and respective vias. The microneedles extend, each, from a base surface of the substrate. Each of the vias extends through a thickness of the substrate, thereby forming a corresponding set of apertures on the base surface. Each of the apertures is adjacent to a respective one of the microneedles. The device further may comprise two or more electrodes, these including a sensing electrode and a reference electrode. Each electrode may comprise an electrically conductive material layer that coats a region of the substrate, so as to coat at least some of the microneedles and neighboring portions of said base surface. Related devices, apparatuses, and methods of fabrication and use of such devices may be provided.

Abstract: Solid-state electrodes comprising Redox Active Surface Areas for use in analyte sensing devices and various product platform devices.

Abstract: A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the device comprising an enzyme layer, the method comprising: determining sensitivities of the device for each of one or more calibration solutions; determining a degree of modulation for the sample to be measured, determining a degree of modulation for each calibration solution; wherein said determining of each of the degrees of modulation comprises estimating the concentration of an enzyme modulator in the enzyme layer of the device; and calculating the sensitivity of the device for the sample, wherein the said calculating comprises adjusting the sensitivity of the device for each calibration solution by a factor comprising the determined degrees of modulation of the sample and the calibration solution.

Abstract: A biosensor electrode, comprising: a porous metal structure; and a carbon nanotube structure comprising a plurality of carbon nanotubes, the carbon nanotube structure is fixed on a surface of the porous metal structure, wherein the porous metal structure and the carbon nanotube structure are shrunk together to form a plurality of wrinkled parts.

Abstract: An apparatus and method, the apparatus including a channel; at least one pair of electrodes provided within sides of the channel; a conductor configured to move through the channel such that when the conductor is positioned between the at least one pair of electrodes a current path is provided through the at least one pair of electrodes and the conductor; and wherein the at least one pair of electrodes are configured such that the position of the conductor within the channel controls the length of the current path and enables a time varying voltage to be provided.

Abstract: Techniques described herein can apply AC signals with different phases to different groups of nanopore cells in a nanopore sensor chip. When a first group of nanopore cells is in a dark period and is not sampled or minimally sampled by an analog-to-digital converter (ADC) to capture useful data, a second group of nanopore cells is in a bright period during which output signals from the second group of nanopore cells are sampled by the analog-to-digital converter. The reference level setting of the ADC is dynamically changed based on the applied AC signals to fully utilize the dynamic range of the ADC.

Abstract: Devices, apparatus and methods for sequencing macromolecules are disclosed. The devices and apparatus include independently controllable fluid channels bi-directionally coupled to a measurement module.

Abstract: An active matrix electrowetting on dielectric (AM-EWoD) device including dual substrates with thin-film transistors (TFT) and capacitive sensing. As depicted herein the bottom substrate includes a first plurality of electrodes to propel various droplets through a microfluidic region, while the top substrate includes a second plurality of electrodes that are configured to interrogate the droplets with capacitive sensing. In some embodiments, the top substrate has zones of high-resolution sensing and zones of low-resolution sensing.

Abstract: In a sensor control device which controls a sensor, a first filter unit extracts a first filtered signal obtained by attenuating a frequency component higher than a first cutoff frequency from a digital signal indicating a current-application control value for a pump current, and a second filter unit extracts a second filtered signal obtained by attenuating a frequency component higher than a second cutoff frequency from the first filtered signal. A cutoff frequency setting unit sets at least one of the first cutoff frequency and the second cutoff frequency such that the sensor control device can control at least two types of sensors.

Abstract: An embodiment provides a method for compensating for inteferants in measurement of alkalinity in a reagent-less system, including: introducing an aqueous sample into a measurement device comprising one or more series of electrodes; applying an electrical signal to the aqueous sample using the one or more series of electrodes, wherein the electrical signal is selected from the group consisting of: current and voltage; identifying, during application of the electrical signal, that the electrical signal reaches an oxidation threshold and measuring, prior to reaching the oxidation threshold, a first electrical response to the electrical signal, the first electrical response attributable to interferants in the aqueous sample; identifying, during application of the electrical signal, that the electrical signal reaches an endpoint and measuring, from the oxidation threshold to the endpoint, a second electrical response to the electrical signal; and measuring an alkalinity of the aqueous sample based upon a differenc

Abstract: Provided in one example is a sensor having at least one fissure, the fissure being at least partially filled by at least one polymer formation extending vertically within a passivation layer. The polymer formation protects the underlying metal containing layer from corrosive solutions. Provided in another example is a method of forming the polymer formation in a fissure of a sensor.

Abstract: Isoelectric focusing devices configured for multiplex separation of sample components of interest in a polymeric separation medium are provided. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.