Patents Examined by Caralynne E Helm
  • Patent number: 11938228
    Abstract: A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: March 26, 2024
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron Manzi, Amritpreet Birdi
  • Patent number: 11931485
    Abstract: A biocompatible and bioresorbable implantable device that is intended to be deployed in the middle meningeal artery through intra-arterial catheters and release an anesthetic agent for a prolonged period into the branches of the middle meningeal artery to treat severe headaches including migraine and trigeminal neuralgias. The implantable device may be a mesh with multiple helical loops, fenestrated collapsible hollow shell or spheroid, or folded sheath.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: March 19, 2024
    Inventor: Adnan I. Qureshi
  • Patent number: 11931369
    Abstract: Disclosed herein are compositions and methods for delivering compositions to a subject in need of treatment for epilepsy. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering cannabidiol and CBD-containing compositions to subjects in need of treatment for epilepsy.
    Type: Grant
    Filed: July 24, 2023
    Date of Patent: March 19, 2024
    Assignee: POVIVA CORP
    Inventors: John Docherty, Christopher Andrew Bunka
  • Patent number: 11896738
    Abstract: An electrically conductive hyaluronic acid-based hydrogel is disclosed that is a crosslinked porous scaffold having a graphene-based material encapsulated or in contact within the porous scaffold. The graphene-based material includes one or more of graphene oxide foam, reduced graphene oxide foam, nanoplatelets, nanoparticles, or fibers. The porous scaffold may be formed over an implanted bioelectronic device such as a microelectrode array having a plurality of electrodes. The porous scaffold may also be used to control the differentiation of cells including Neural Stem/Progenitor Cells (NS/PCs).
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: February 13, 2024
    Inventor: Rebecca Bierman
  • Patent number: 11878013
    Abstract: The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: January 23, 2024
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Myung-Ae Bae, Dae-Seop Shin, Jung Yoon Yang, Kyu Seok Hwang, Seong Soon Kim, Byung Hoi Lee, Ki Young Kim, Won Hoon Jung, Jae Chun Woo
  • Patent number: 11806320
    Abstract: Storage stable aqueous ready-to-administer formulations comprising isoproterenol are presented with desirable stability characteristics. In preferred aspects, formulations are terminally sterilized and packaged in a suitable format, such as a polymeric bag with metalized overwrap and include a non-contact oxygen scavenger.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: November 7, 2023
    Inventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
  • Patent number: 11752098
    Abstract: Disclosed are compositions and methods for microneedle patches comprising diblock copolymer micelles designed for pH cascade and H2O2 triggered insulin delivery.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: September 12, 2023
    Assignee: North Carolina State University
    Inventors: Zhen Gu, Jinqiang Wang
  • Patent number: 11707483
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: July 25, 2023
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
  • Patent number: 11684703
    Abstract: Intraocular pressure sensors, systems, and methods of use. Implantable intraocular pressure sensing devices that are hermetically sealed and adapted to wirelessly communicate with an external device. The implantable devices can include a hermetically sealed housing, the hermetically sealed housing including therein: an antenna in electrical communication with a rechargeable power source, the rechargeable power source in electrical communication with an ASIC, and the ASIC in electrical communication with a pressure sensor.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: June 27, 2023
    Assignee: Qura, Inc.
    Inventors: Douglas P. Adams, Amitava Gupta
  • Patent number: 11607383
    Abstract: The present disclosure describes a method of delivering a therapeutic agent providing a microneedle array including a plurality of microneedles, the plurality of microneedles including a conductive coating disposed thereon, wherein the conductive coating includes the therapeutic agent and a conducting polymer; implanting the microneedle array in a dura mater of a subject in need thereof, wherein the microneedle array pierces the dura mater; and applying an electrical stimulus to the microneedle array to provide a controlled release of the therapeutic agent from the conductive coating, across the dura mater, to the central nervous system of the subject.
    Type: Grant
    Filed: October 13, 2020
    Date of Patent: March 21, 2023
    Assignee: University of Washington
    Inventors: Rajiv Saigal, Joyce Huang
  • Patent number: 11602721
    Abstract: A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: March 14, 2023
    Inventors: Steven Lu, Peter D. Gabriele, Julia Donnelly, Brian Ginn, Charles Brendan Nicholson, Jeremy J. Harris, Michael S. Flemmens
  • Patent number: 11590064
    Abstract: The present invention provides an anhydrous, sprayable sunscreen composition comprising one or more oil soluble UV filters and a combination of film formers comprising at least one copolymer of trimethylolpropane, adipic acid, neopentyl glycol and hexanediol and at least one acrylates/octylacrylamide copolymer having a molecular weight of at least 50 kDA measured using Dynamic Light Scattering.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: February 28, 2023
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Navya Mudya, Frank C. Sun
  • Patent number: 11571372
    Abstract: A cosmetic ingredient including at least one plant squalane and at least one mixture of C24 to C48 alkanes, in at least dimeric form, chosen amongst the alkanes of formula (I), where n is 1 or 0, R1, R?1, R2, R?2, R3 and R?3, which may be identical or different, are chosen amongst hydrogen atoms, methyl radicals, and linear C8 to C30 alkyl radicals, at least one of R1, R?1, R2, R?2, R3 and R?3 is chosen amongst the linear C8 to C30 alkyl radicals, and at least one and at most one of R1, R?1, R2, R?2, R3 and R?3 is a methyl radical. The mixture of C24 to C48 alkanes have a viscosity between 12 and 25 mm2/s at 40° C.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: February 7, 2023
    Assignee: BIOSYNTHIS
    Inventors: Thierry Bernoud, Julien Magne, Antoine Piccirilli
  • Patent number: 11517512
    Abstract: Disclosed herein are personal care compositions comprising Zn:usnate complexes having a 1:2 zinc to usnate molar ratio. Methods of making and using the compositions are also provided. The personal care compositions may include a cleansing component and an antibacterial component, wherein the antibacterial component comprises Zn:usnate complexes having a 1:2 zinc to usnate molar ratio.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: December 6, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Stanislav Jaracz, Long Pan, Karthik Sambanthamoorthy, Junhong Mao, Aixing Fan
  • Patent number: 11504307
    Abstract: A biphasic topical product comprising a hydrophilic phase and a lipophilic phase floating on said hydrophilic phase. A method for preparing biphasic topical products.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: November 22, 2022
    Assignee: CMED AESTHETICS S.R.L.
    Inventor: Elena Bottai
  • Patent number: 11504395
    Abstract: The invention is concerned with use of oral inorganic pyrophosphate for preventing and/or reducing tissue calcification, particularly soft tissue calcification, and/or diseases or disorders characterized by low plasma PPi levels, as, e.g.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: November 22, 2022
    Assignee: Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis
    Inventors: András Váradi, Dóra Dedinszki, Flóra Mária Szeri, Piet Borst, Jan Koenraad Van De Wetering
  • Patent number: 11478429
    Abstract: A two-compartment capsule includes a body, a diaphragm between, which seals off the body and provides a first compartment to hold a first dry ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding a second dry ingredient. This disclosure also provides particular formulations for use in such a capsule. Examples include a probiotic, a digestive enzyme, an expectorant, a bronchodilator, a stool softener, a platelet aggregation inhibitor, a form or derivative of vitamin E, a statin, and aspirin.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: October 25, 2022
    Assignee: ComboCap, Inc.
    Inventor: Tobias Johan Louw
  • Patent number: 11464719
    Abstract: Cosmetic and dermatological compositions, including color changing compositions, are provided which typically include a plurality of synthetic particles having a size in the micrometer or nanometer range. Each synthetic particle typically includes one or more aggregates of a pigment selected from phenoxazone, phenoxazine, and a derivate or precursor thereof, and a stabilizing material which has a refractive index larger than 1.45; the aggregates having a size larger than about 100 nm and the composition being biodegradable and biocompatible.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: October 11, 2022
    Assignee: Northeastern University
    Inventors: Leila Deravi, Camille A. Martin, Amrita Kumar
  • Patent number: 11406592
    Abstract: An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: August 9, 2022
    Assignee: Mati Therapeutics Inc.
    Inventors: Eugene de Juan, Jr., Cary Reich, Stephen Boyd, Hanson S. Gifford, III, Mark Deem
  • Patent number: 11406742
    Abstract: A coating for an expandable portion of a catheter comprising a lipophilic matrix and a plurality of micro-reservoirs dispersed in the lipophilic matrix is disclosed. The plurality of micro-reservoirs comprises an active agent. A coating formulation and a method for forming the coating are also disclosed. A catheter comprising the coating on the expandable portion and a method for treating a condition are also provided.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: August 9, 2022
    Assignee: M.A. Med Alliance SA
    Inventors: Michael Thomas Ahlering, Ronald Kenichi Yamamoto, Robert John Elicker, Tien Thuy Nguyen, John Edwin Shulze, Jelle Jurjen Zoethout