Patents Examined by Carlos Azpuru
  • Device for adsorbing odours
    Patent number: 10772985
    Abstract: The invention relates to a device for adsorbing odours comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one spice. Such a device is particularly useful for adsorbing and masking body odours.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: September 15, 2020
    Assignees: Institut Corie, Ecole Superieore De Physique Et De Chimie Industrielle (ESPCI), Cole Nationale Superieore De Chime De Paris (ENSCP), Centre National De La Recherche Scientifique, Cemag Care
    Inventors: Aurélie Thuleau, Isabelle Fromantin, Vincent Semetey, José Dugay, Jean-François Le Meur
  • Sumatriptan promethazine pharmaceutical compositions
    Patent number: 10772840
    Abstract: Pharmaceutical compositions and methods are provided to treat headache, headache-associated symptoms, photophobia, or adverse effects associated with the headache. Also provided herein are small smooth particulates comprising a 5HT1B/1D receptor agonist. Compositions for oral administration are described herein wherein the compositions comprise a combination of active agents, such as a 5HT1B/1D receptor agonist and one or more antiemetics.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: September 15, 2020
    Assignee: CHARLESTON LABORATORIES, INC.
    Inventors: Paul Bosse, John Ameling, William Kozarek, Bernard Schachtel, John Higgins
  • Halogenated heterocyclic N-halamine coated garbage bags
    Patent number: 10765770
    Abstract: Articles can be provided with odor resistance by applying a dispersion of a halogenated heterocyclic N-halamine in an inert liquid carrier onto the surface of the article and allowing the inert liquid carrier to penetrate into it. The N-halamine accordingly becomes deposited on the surface of the article after the inert liquid carrier penetrates into the article. This method can be used to provide odor resistance to a variety of substrates, including garbage bags. It can also be used to deposit other functional particulates onto the surface of substrates having sufficient porosity to take up the vehicle. For instance, such functional particles can be oxidants that display antimicrobial and/or enzyme inhibitory efficacy or particles having toxin interaction potentials through oxidative degradation or adsorption of toxic substances in air and/or water, such as fluoride uptake by metal oxide microparticles.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: September 8, 2020
    Assignee: THE GLAD PRODUCTS COMPANY
    Inventors: Jeffrey F. Williams, Simon Johnston
  • Magnetic particle conjugates, micelles, and methods of delivering agents
    Patent number: 10765744
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: September 8, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Carlos Rinaldi, Sun Hao, Brent S. Sumerlin
  • RGD and transferrin nanoparticle composition
    Patent number: 10765637
    Abstract: Provided is a composition which can be utilized for drug delivery systems that can penetrate the blood brain barrier, and has low cytotoxicity. A nanoparticle composition comprises nanoparticles to the surface of which a first substance and a second substance each having specificity to a tumor cell are bound, wherein the first substance having specificity to the tumor cell is a peptide comprising an amino acid sequence of arginine-glycine-aspartic acid, and wherein the second substance having specificity to the tumor cell is an iron-binding protein, and wherein the nanoparticles each comprise an outer layer and vesicles enveloped by the outer layer and the nanoparticles each comprise, as membrane components, a PEGylated phospholipid, a fatty acid with a melting point of 30° C. or more, and a non-PEGylated phospholipid.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: September 8, 2020
    Assignee: TOYO UNIVERSITY
    Inventors: Toru Maekawa, Sakthikumar Dasappan Nair, Sheikh Mohamed Mohamed, Srivani Veeranarayanan
  • Topical formulation of hyperbranched polyglycerol-coated particles thereof
    Patent number: 10758459
    Abstract: Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core or coated thereon. The HPG coating can be modified to adjust the properties of the particles. For example, unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups on tissue or otherwise interact with tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HPG coated nanoparticles.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: September 1, 2020
    Assignee: YALE UNIVERSITY
    Inventors: Yang Deng, Asiri Ediriwickrema, William M. Saltzman
  • Compositions of obeticholic acid and methods of use
    Patent number: 10758549
    Abstract: The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: September 1, 2020
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Richard Gail Lancaster, Kay K. Olmstead, Masashi Kagihiro, Mitsuhiro Matono, Ikuko Taoka, Mark Pruzanski, David Shapiro, Roya Hooshmand-Rad, Richard Pencek, Cathi Sciacca, Lise Eliot, Jeffrey Edwards, Leigh A. MacConell, Tonya K. Marmon
  • Active agent loaded uniform, rigid, spherical, nanoporous calcium phosphate particles and methods of making and using the same
    Patent number: 10758478
    Abstract: Uniform, rigid, spherical nanoporous calcium phosphate particles that define an internal space and an amount of active agent present in the internal space are provided. Also provided are topical delivery compositions that include the active agent loaded particles, as well as methods of making the particles and topical compositions. The particles and compositions thereof find use in a variety of different applications, including active agent delivery applications.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: September 1, 2020
    Assignee: Laboratory Skin Care, Inc.
    Inventors: Tetsuro Ogawa, Akira Yamamoto
  • Compositions of obeticholic acid and methods of use
    Patent number: 10751349
    Abstract: The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: August 25, 2020
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Richard Gail Lancaster, Kay K. Olmstead, Masashi Kagihiro, Mitsuhiro Matono, Ikuko Taoka, Mark Pruzanski, David Shapiro, Roya Hooshmand-Rad, Richard Pencek, Cathi Sciacca, Lise Eliot, Jeffrey Edwards, Leigh A. MacConell, Tonya K. Marmon
  • Thiolated devitalized tissue particle implantable hydrogel
    Patent number: 10744229
    Abstract: Methods and compositions for use in repairing and/or regenerating tissues are disclosed. A hydrogel precursor composition comprising functionalized tissue particles and functionalized hyaluronic acid that can be deposited into an implant site and converted into a crosslinked hydrogel network which retains the tissue particles at the implant site is disclosed. Also disclosed are methods of forming functionalized tissue particles and functionalized hyaluronic acid for use herein. Kits containing reagents for producing the hydrogel precursor composition are also disclosed, along with methods of producing the hydrogel precursor composition.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: August 18, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jakob M. Townsend, Michael S. Detamore
  • Methods of use and processes for preparing alcoholic solutions of polyvinylpyridine polymers
    Patent number: 10743539
    Abstract: Provided is a process for preparing an alcoholic solution of a polyvinylpyridine polymer having biocidal and biocompatibility properties. The alcoholic solution is ready-to-graft in order to confer biocidal properties to various surfaces and to prevent biofilm formation on such surfaces. Also provided are methods of using the alcoholic solution, such as for controlling the growth of bacteria, fungi and/or viruses, and/or for preventing digestion of wood cellulose by wood-boring insects.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: August 18, 2020
    Assignee: DeBogy Molecular, Inc.
    Inventors: Houssam Bouloussa, Othman Bouloussa
  • Implants having a drug load of an oxysterol and methods of use
    Patent number: 10736993
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: August 11, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
  • Risperidone biodegradable implant
    Patent number: 10736965
    Abstract: The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: August 11, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Steven Siegel, Karen Winey
  • Bioactive components conjugated to dissolvable substrates of microneedle arrays
    Patent number: 10737083
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: August 11, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Geza Erdos
  • Sternum replacement implant
    Patent number: 10729808
    Abstract: The invention relates to a sternum replacement implant.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: August 4, 2020
    Assignee: I.CERAM
    Inventors: Daniel Setton, Fabrice Fiorenza, François Bertin, Frank Sturtz, Eric Denes, Delphine Donnez
  • Nanoceria for neutralizing free radicals
    Patent number: 10729717
    Abstract: A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: August 4, 2020
    Assignee: Cerion Enterprises LLC
    Inventors: Kenneth Joseph Reed, Wendi Ann Costanzo, Joseph Samuel Erlichman, Eric Leslie Bell
  • Neocartilage compositions and methods for modifying proteoglycan content
    Patent number: 10729814
    Abstract: The present disclosure relates to cartilage repair compositions and methods for modifying the proteoglycan content of the compositions. Specifically, the methods relate to serum free, collagen free neocartilage made from chondrocytes that can be used for implants. Proteoglycans, such as aggrecan and sulfated glycosaminoglycan are used and the content modified using temperature changes.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: August 4, 2020
    Assignee: Isto Technologies, Inc.
    Inventors: Neil Kizer, Nicole M. Bergmann, Gary Gage, Huston Davis Adkisson, Michael Maloney
  • Drug delivery polymer particles with hydrolytically degradable linkages
    Patent number: 10729805
    Abstract: Described are polymers and methods of forming and using same.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: August 4, 2020
    Assignee: Terumo Corporation
    Inventors: Gregory M. Cruise, Xinping Wu, Gloria Hincapie, Yue Wu
  • Nutritional supplements for growth enhancement in pre-pubertal adolescents
    Patent number: 10729704
    Abstract: Provided are nutritional supplements designed for enhancing the growth, particularly the linear growth, of pre-pubertal children with a stature measure short compared to the norm. The nutritional composition comprises an energy source, and a combination of micronutrients, and is adapted separately for the nutritional needs of male or female adolescents.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: August 4, 2020
    Assignee: NG Solutions LTD
    Inventors: Moshe Phillip, Michal Yackobovitch-Gavan, Raanan Shamir, Hadassa Bymel
  • Biphasic compositions for tissue augmentation
    Patent number: 10722445
    Abstract: Methods and compositions for use in tissue volume replacement are provided. The present invention comprises compositions comprising a combination of materials, comprising preferably a solid polymer particle phase and a gel phase, and also comprises single phase compositions. More particularly, preferred embodiments comprise a solid polymer particle phase made of materials comprising Gore-Tex (micronized e-PTFE), PDS II (polydioxanone, a monofilament), NUROLON (a long chain aliphatic polymer Nylon 6 or Nylon 6,6) ETHILON (a long chain aliphatic polymer Nylon 6 and Nylon 6,6), PROLENE (Polypropylene, isotactic crystalline stereoisomer of polypropylene, a synthetic linear polyolefin.), VICRYL (copolymer made from 90% glycolide and 10% L-lactide), silk, MONACRYL (poly ?-caprolactone.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: July 28, 2020
    Inventor: Inna Dyer