Patents Examined by Carol Lynn Cseh
  • Patent number: 4900841
    Abstract: This invention relates to a process for the preparation of substituted sulfonamidobenzamides which compounds are known antiarrhythmic agents and to the novel N-acylaziridine employed therein.
    Type: Grant
    Filed: April 20, 1987
    Date of Patent: February 13, 1990
    Assignee: Schering A.G.
    Inventor: Thomas K. Morgan, Jr.
  • Patent number: 4886886
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: December 12, 1989
    Assignee: American Home Products Corporation
    Inventors: Brian A. McKittrick, Alan H. Katz
  • Patent number: 4883799
    Abstract: N-[4-{1-Hydroxy-3-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimid in-6-yl)prop-2-yl )benzoyl]-glutamic acid, it salts, and derivatives thereof, have an inhibitory effect on one or more enzymes which utilize folic acid and can be used, alone or in combination, to inhibit the growth of those neoplasms which otherwise depend upon the enzymes so inhibited. The compounds can be prepared through catalytic hydrogenation of a protected derivative of N-[4-{1-hydroxy-3-(2-amino-4-hydroxy-pyrido[2,3-d]pyrimidin-6-yl)prop-2-en -2-yl)benzoyl]glutamic acid and removal of the protecting groups.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: November 28, 1989
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Cheol-min Yoon
  • Patent number: 4874875
    Abstract: Perfluoro-oxaziridines, characterized by the presence of an aminic group in position 3 of the oxaziridine ring, of the formula: ##STR1## wherein each R is independently either F or a perfluoro-alkyl group, and a process for their preparation, consisting in reacting the corresponding perfluoroimine with H.sub.2 O.sub.2, in the presence of a base in a dipolar aprotic solvent.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: October 17, 1989
    Assignee: Ausimont S.r.l.
    Inventors: Walter Navarrini, Darryl D. Desmarteu
  • Patent number: 4859691
    Abstract: Disclosed are 1,2-benzisoxazole and 1,2-benzisothiazole derivatives represented by formula I ##STR1## wherein X represents oxygen or sulfur; Z rep;esents carbon (CH) so as to complete the imidazol-1-yl ring radical or Z represents nitrogen (N) so as to complete the 1,2,4-triazol-1-yl ring radical; R.sub.1 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; R.sub.2 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; or R.sub.1 and R.sub.2 combined represent lower alkylene; or R.sub.1 combined with R.sub.5 located on the Z-carbon atom of the imidazolyl radical represents C.sub.2 -C.sub.4 -alkylene; R.sub.3 and R.sub.4 independently represent hydrogen, lower alkyl, cycloalkyl, halogen, trifluoromethyl, cyano, nitro, amino, hydroxy, lower alkanoyloxy, carbocyclic aroyloxy, lower alkoxy, or carbocyclic aryl; or R.sub.3 and R.sub.4, together when located on adjacent carbon atoms, represent lower alkylenedioxy; or R.sub.3 and R.sub.
    Type: Grant
    Filed: July 8, 1987
    Date of Patent: August 22, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Robert M. Bowman