Abstract: The present invention concerns an actuator for an implantable hearing aid for implantation into the human middle ear. The actuator comprises a substantially elongate piezoelectric component (34, 36) having first and second operating end faces (41, 43), said end faces extending substantially at right angles to the longitudinal axis of the piezoelectric component. Also there is provided a frame component comprising at least one flextensional amplifier element (32), the flextensional amplifier element being integral with and connecting first and second frame end portions (42, 44), the first and second frame end portions also extending substantially at right angles to longitudinal axis of the piezoelectric component when fitted thereto, whereby the first and second end portions are in contact with the piezoelectric component end faces.

Abstract: Apparatuses and methods for corrective guidance of eating behavior of a patient equipped with a gastric restriction device. The apparatus provides continuous monitoring or one or more parameters related to food passing through the gastric restriction device. Each monitored parameter is processed to provide a visual indication of the current eating behavior. The visual indication is used as input to the patient or a caregiver to modify the eating behavior. In some embodiments, the apparatus includes an emergency relief mechanism that automatically relieves excess pressure developing in the gastric restriction device. In some embodiments, the apparatus is enabled to deliver an appetite suppressant to modify the eating behavior.

Abstract: An apparatus for treating urinary incontinence, comprising a node; a support section adapted for providing urethral support attached to the node; and, an anchoring section adapted for resisting movement of the apparatus attached to the node; wherein the node is no longer than 30% of the entire length of the apparatus comprising the node, support section and the anchoring section together.

Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

Abstract: A system includes an adjustable implant configured for implantation internally within a subject, the adjustable implant comprising a first permanent magnet configured for rotation about a first axis, the first permanent magnet operatively coupled to a drive transmission configured to alter a dimension of the adjustable implant. The system further includes an external adjustment device configured for placement on or adjacent to the skin of the subject, the external adjustment device comprising a second permanent magnet configured for rotation about a second axis and a third permanent magnet configured for rotation about a third axis different from the second axis; and wherein cooperative rotation of the second permanent magnet about the second axis and rotation of the third permanent magnet about the third axis result in rotation of the first permanent magnet about the first axis.

Abstract: Described are pelvic implants and methods of surgically placing pelvic implants that provide treatment for pelvic floor disorders by support of the levator by creating an incision that allows access to a region of tissue of the pelvic floor and inserting a pelvic implant comprising a tissue support portion delivered by a delivery tool. A pelvic implant for supporting levator tissue comprising: a tissue support portion having a first end and a second; a tissue fastener disposed on the first end of the tissue support portion for fastening it to levator tissue; a guide extension portion disposed on the second end of the tissue support portion; and a support backer member attachable to the guide extension portion to adjust a tension of the tissue support portion and concomitantly the levator tissue.

Abstract: In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.

Abstract: Hearing systems for both hearing impaired and normal hearing subjects comprise an input transducer and a separate output transducer. The input transducer will include a light source for generating a light signal in response to either ambient sound or an external electronic sound signal. The output transducer will comprise a light-responsive transducer component which is adapted to receive light from the input transducer. The output transducer component will vibrate in response to the light input and produce vibrations in a component of a subject's hearing transduction pathway, such as the tympanic membrane, a bone in the ossicular chain, or directly on the cochlea, in order to produce neural signals representative of the original sound.

Abstract: An implantable device comprises a reservoir that contains a fluid for filling an inflatable portion of a gastric band. A device is coupled to the reservoir and includes stored potential energy having a first state and a second state. The first state represents a higher level of potential energy and the second state represents a lower level of potential energy. The implantable device further comprises a filling valve coupled between the reservoir and the gastric band, and the filling valve is configured to be opened in response to a first telemetric signal. The stored potential energy decreases from the first state to the second state when the filling valve is open, and a filling amount of the fluid moves from the reservoir to the gastric band when the stored potential energy decreases from the first state to the second state.

Abstract: A slotted shield for a surgical tack, including a body adapted to engage a tack head. The shield has at least one slot having a width, defined by the body. Optionally, the shield is mounted on a tack head on which said shield is mounted.

Abstract: Magnetically responsive therapeutic carriers comprise nanoparticles including single-domain nanoparticles comprising magnetite and having an average particle size ranging between 1 and 50 nanometers, clusters of the single-domain nanoparticles, the clusters having an average cluster size ranging between 5 and 1000 nanometers, and mixtures of the two. The single-domain nanoparticles are encapsulated with a silica coating. A silane coupling agent is bonded to the silica coating and has a specific pendant functional group capable of selectively binding with the therapeutic. Preferably, the bond between the specific pendant functional group and the therapeutic is a covalent bond. The movement of magnetically responsive nanoparticle therapeutic constructs, with concentration and extravasation/endocytosis at a target site, such as cancerous tumors, uses a controllable magnetic field generator adapted to move the therapeutic constructs in three dimensions, and is enhanced using a repetitively-varying magnetic field.

Abstract: The invention provides, in various embodiments, aspects of soft tissue anchors, adjustable length/tension slings, interconnects between slings and soft tissue anchors, delivery devices and systems for implanting supportive slings, and methods relating to anchoring, adjusting and implanting supportive slings.

Abstract: An apparatus and method are disclosed for treating overweight and obese patients by applying a restrictive Artificial Gastric Valve (AGV) on part of the stomach. The apparatus includes a mechanism to control the opening of the AGV automatically on demand, dynamically and progressively. The controlled opening of the AGV inside the stomach controls and regulates the flow of food.

Abstract: Methods and devices for minimally-invasive delivery of radiation to the posterior portion of the eye including a cannula comprising a distal portion connected to a proximal portion and a means for advancing a radionuclide brachytherapy source (RBS) toward the tip of the distal portion; a method of introducing radiation to the human eye comprising inserting a cannula between the Tenon's capsule and the sclera of the human eye and emitting the radiation from the cannula on an outer surface of said sclera.

Abstract: A magnetic field therapy apparatus includes a first wire coil, a second wire coil and an electrically conductive member connecting the coils in series. The coils are wound in the same direction. In a preferred embodiment the coils are wrapped around a single bobbin, with the first coil forming a bottom layer and the second coil wrapped around the first coil and forming a top layer. AC power coupled to the coils energizes the coils and generates a magnetic field within the bobbin interior region. When current enters one coil it induces current in the other coil, thereby creating a scalar effect, producing energy in the form of a helix. The waves are identical, but out of phase temporally, that is, physically identical, but 180 degrees out of phase in terms of time. In an alternate embodiment, the coils may be on separate bobbins. A trigger may be applied to the part of a body undergoing therapy.

Abstract: Methods and devices for minimally-invasive delivery of radiation to the posterior portion of the eye including a cannula comprising a distal portion connected to a proximal portion and a means for advancing a radionuclide brachytherapy source (RBS) toward the tip of the distal portion; a method of introducing radiation to the human eye comprising inserting a cannula between the Tenon's capsule and the sclera of the human eye and emitting the radiation from the cannula on an outer surface of said sclera.

Abstract: Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.

Abstract: Improved methods and apparatus to secure a urethral sling to pubic bone in a sub-urethral location to support the urethra and alleviate incontinence are disclosed. The urethral sling is preferably formed of a flexible sheet material extending between opposed first and second sling ends and bounded by opposed first and second sling sides. The urethral sling is selectively tensioned in a central portion intermediate the first and second sling ends and/or in one or both of end portions bracketing the central portion. In one embodiment, pre-positioned plicating lines in the central portion are selectively drawn and tied to slacken the central portion and tension the end portions. In further embodiments, bone anchor lines passed through locations displaced from the sling ends are drawn and fixed to tension the central portion between the displaced locations and slacken the end portions.

Abstract: A method of treatment of the symptoms of tinnitus is disclosed in which a non-sinusoidal pulsating electric waveform having a pulse repetition rate (frequency) less than 100 Hz is applied to a headphone or an earphone or a like acoustic transducer worn by a tinnitus sufferer. Square, sawtooth and triangular waveforms are suitable. Preferably a sequence of square, triangular, square and square waveforms each of duration of 3 minutes, and separated by a silent pause of 10-15 seconds, is applied. Various devices for applying such waveform(s) to such transducers are disclosed including a clinical oscillator, an internet distribution system, a playback device, electronic or magnetic storage devices, and a cochlear implant.

Abstract: Disclosed is a pressure-to-tension conversion device for treating urinary incontinence. The pressure-to-tension conversion device includes resilient sections which are inserted in and occupy Retzius spaces positioned in left and right sides of the urethra in front of the urinary bladder, respectively, and a support extending below the urethra and across the resilient sections in a “V” shape, wherein if the resilient sections are deformed as the abdominal pressure increases and the Retzius spaces contract, the support is tensioned, thereby supporting the urethra, so that the urinary incontinence can be treated. Consequently, the length of operation time for transplanting the pressure-to-tension conversion device can be shortened, a complication or a side effect can be reduced, and the charges of operation can be reduced. In addition, expensive operation materials can be substituted by the pressure-to-tension conversion apparatus, the costs for operation materials can be saved.