Patents Examined by Catherine Mader
  • Patent number: 8906844
    Abstract: The invention relates to peptides derivatized with a hydrophilic polymer which, in some embodiments, bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used in some embodiments, for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates, in further embodiments, to methods of using and methods of making the peptides of the invention.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: December 9, 2014
    Assignee: Biogen Idec Hemophilia Inc.
    Inventors: Adam R. Mezo, Kevin A. McDonnell
  • Patent number: 8895696
    Abstract: Methods for building peptide chains containing sulfonyl modified amines at the N-terminus, or, within amino acid side chains, of a growing peptide in a solid-phase peptide synthesis are described. Further, compositions having a sulfonyl modified amine attached to the N-terminus, or within an amino acid side chain, of a polypeptide containing three or more amino acid residues are described.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: November 25, 2014
    Assignee: The University of Toledo
    Inventors: Steven J. Sucheck, Rommel S. Talan, Partha Karmakar
  • Patent number: 8877738
    Abstract: The present invention relates to monomeric and multimeric peptidic compounds which have antipathogenic, in particular antiviral or/and antibacterial activity. In a preferred aspect, the peptide compounds of the invention have an activity in respect of a broad spectrum of viruses, both DNA and RNA viruses, irrespective of whether they possess virus envelope or not. Further, the present invention refers to compositions comprising said peptidic compounds for medical use, i.e. for the treatment or prevention of pathogenic, in particular viral or/and bacterial infections.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: November 4, 2014
    Assignee: Spiderbiotech S.r.L.
    Inventors: Andrea Giuliani, Giovanna Pirri, Lorena Pizzuto, Santo Landolfo, Giorgio Gribaudo, David Lembo, Davide Gibellini
  • Patent number: 8871903
    Abstract: Methods to synthesize self-assembling peptides embedded with complex organic electronic subunits are provided.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 28, 2014
    Assignee: The Johns Hopkins University
    Inventors: John D. Tovar, Allix M. Sanders
  • Patent number: 8871706
    Abstract: The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogous of native hGhrelin.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: October 28, 2014
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Zheng Xin Dong, Michael DeWitt Culler, Rakesh Datta, John E. Taylor
  • Patent number: 8865647
    Abstract: If albumin is added to a pharmaceutical formulation containing acylated insulin described in WO 2009/022005 and WO 2009/022013, the acylated insulin can be kept in solution after subcutaneous injection.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: October 21, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Helle Naver, Svend Havelund, Peter Madsen
  • Patent number: 8859730
    Abstract: A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (FIG. 1 (a)): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: October 14, 2014
    Inventor: Xuechen Li
  • Patent number: 8859726
    Abstract: The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilised to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the adsorbed immunoglobulin containing proteins; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods in that each of the ligands comprises one or more of a protein A domain (E, D, A, B, C), or protein Z, or a functional variant thereof, with at least one of the monomers having a substitution of the C-terminal most proline residue after the third alpha-helix.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: October 14, 2014
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Tomas Bjorkman, Gustav Rodrigo
  • Patent number: 8859731
    Abstract: A method of selectively introducing a substituent into a protein proximal to a binding site on the protein for a homing peptide, comprising: (a) contacting the protein with a compound comprising a homing peptide having the ability to bind to the binding site of the protein; and (b) allowing a moiety on the protein proximal to the binding site to react with the compound comprising the homing peptide, thereby to transfer the substituent G onto the protein.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: October 14, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Mikael Kofod-Hansen, Henning Ralf Stennicke, Soeren Oestergaard, Henrik Oestergaard
  • Patent number: 8846603
    Abstract: The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: September 30, 2014
    Assignee: Synageva Biopharma Corp.
    Inventors: Anthony Quinn, Alex J. Harvey, Zhinan Xia
  • Patent number: 8846604
    Abstract: The invention provides lipid compositions comprising phospholipids having a high docosahexaenoic acid (DHA) content, which compositions are preferably extracted from natural sources. The lipid compositions are excellent sources of highly bioavailable DHA and they can be used in oral delivery vehicles, dietary supplements, functional foods, and the like.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: September 30, 2014
    Assignee: Artic Nutrition AS
    Inventors: Hogne Hallaraker, Jan Remmereit, Alvin Berger
  • Patent number: 8841258
    Abstract: The present disclosure serves to reduce the healing time of tissue wounds, including those formed during surgery, whether necessary or elective (including cosmetic surgery), by providing a therapeutic dose of a pancreatic enzyme inhibitor.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: September 23, 2014
    Assignee: The Regents of The University of California
    Inventors: Frank A. DeLano, Geert W. Schmid-Schonbein
  • Patent number: 8841413
    Abstract: The present invention provides novel peptidomimetics, of formula (I), which primarily act as glucose dependent insulin secretagogues. Furthermore, it was found that these peptidomimetics showed glucagon receptor antagonistic activity, along with the GLP-1 receptor agonistic activity.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: September 23, 2014
    Assignee: Cadila Healthcare Limited
    Inventors: Rajesh H. Bahekar, Braj Bhushan Lohray, Vidya Bhushan Lohray, Mukul R. Jain, Kaushik M. Banerjee, Pankaj Ramanbhai Patel
  • Patent number: 8835383
    Abstract: This invention relates to the coagulation of protein containing nutritional compositions in the upper gastro-intestinal tract, more in particular in the stomach and provides a method for reducing suchcoagulation.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: September 16, 2014
    Assignee: N.V. Nutricia
    Inventors: Thomas Ludwig, Claudia Catharina Maria van den Braak, Marianne Klebach, Zandrie Hofman
  • Patent number: 8809026
    Abstract: The present invention relates to processes for extracting lipid from vegetative plant parts such as leaves, stems, roots and tubers, and for producing industrial products such as hydrocarbon products from the lipids. Preferred industrial products include alkyl esters which may be blended with petroleum based fuels.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 19, 2014
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Thomas Vanhercke, James Robertson Petrie, Anna El Tahchy, Surinder Pal Singh, Qing Liu
  • Patent number: 8796200
    Abstract: The invention relates to optimized adhesins and nanoparticles to which said adhesins are bound. The invention furthermore relates to providing said nanoparticles by way of in vivo contrast agents, in particular for the diagnosis of bowel cancer.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: August 5, 2014
    Assignee: Signalomics GmbH
    Inventors: Christoph Block, Karin Mittmann, Claudia Arntz
  • Patent number: 8778872
    Abstract: Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: July 15, 2014
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Richard D. DiMarchi, Binbin Kou
  • Patent number: 8742068
    Abstract: The present invention relates to the use of fragments of heat shock proteins for the treatment and/or prevention of autoimmune diseases such as arthritis or inflammatory diseases such as Inflammatory Bowel Diseases. Preferably bacterial and/or mammalian heat shock proteins belonging to the HSP70 families are used.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: June 3, 2014
    Assignee: Universiteit Utrecht Holding B.V.
    Inventors: Willem van Eden, Ruurd van der Zee
  • Patent number: 8735111
    Abstract: The present invention relates to processes for producing industrial products such as hydrocarbon products from non-polar lipids in a vegetative plant part. Preferred industrial products include alkyl esters which may be blended with petroleum based fuels.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 27, 2014
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Thomas Vanhercke, James Robertson Petrie, Anna El Tahchy, Surinder Pal Singh, Qing Liu
  • Patent number: 8729011
    Abstract: Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: May 20, 2014
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Richard D. DiMarchi, Binbin Kou