Patents Examined by Catherine Scalzo
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Patent number: 4973598Abstract: HMG-CoA reductase-inhibiting compounds of the formula ##STR1## in which R.sup.1 is an optionally substituted alkyl as cycloalkyl radical,R.sup.2 is an optionally substituted aryl or heteroaryl radical,R.sup.3 is hydrogen or an organic radical,B is O or S,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl, aryl or a cation.Type: GrantFiled: February 22, 1989Date of Patent: November 27, 1990Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Rolf Angerbauer, Walter Hubsch, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 4973710Abstract: Water-soluble 1,2-dithiole-3-thione derivatives are prepared by reacting a polyoxyalkylated starting material with sulfur. These derivatives are useful as corrosion inhibitors, particularly in aqueous environments.Type: GrantFiled: August 28, 1989Date of Patent: November 27, 1990Assignee: Petrolite CorporationInventor: Bernardus A. Oude Alink
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Patent number: 4971722Abstract: Thickening agents contain polyether derivatives and low-molecular-weight alkylene glycol alkyl ethers, further common additives as required, and water as the rest, up to 100%. Mono-, di- or trialkylene glycol alkyl ethers are preferred. It is possible to prepare stock solutions with thickener concentrations of 50% and more. The thickening agents, because of their unexpectedly low viscosity, can be handled very well, and they exhibit synergistic effects during thickening, especially of aqueous systems.Type: GrantFiled: September 26, 1988Date of Patent: November 20, 1990Assignee: Akzo N.V.Inventor: Elke Philippsen
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Patent number: 4968448Abstract: An antifoam/defoamer composition comprising a polyether surfactant and a polyhydric alcohol fatty acid ester. The polyether surfactant being admixed with the polyhydric alcohol fatty acid ester in a ratio in the range between 10:90 to 90:10% by weight.Type: GrantFiled: April 5, 1989Date of Patent: November 6, 1990Assignee: Nalco Chemical CompanyInventor: James J. Svarz
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Patent number: 4966902Abstract: Compounds of the formula (I) and their stereoisomers ##STR1## wherein A, B, C' and D independently of one another denote CH or N, in which at least one of the symbols A, B, C' or D must correspond to a nitrogen atom,X denotes CH.sub.2 or oxygen,R.sup.1 denotes a radical bonded to a carbon atom from the series comprising H, trialkylsilyl, halogen, nitro, cyano, alkenyl, alkynyl, amino, cycloalkyl, phenyl, phenxy, alkoxy, alkenyloxy, alkynyloxy, hydroxycarbonyl, alkylthio, cycloalkyloxy, alkylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkoxyalkyl, alkylthioalkyl, alkoxyalkoxy, halogenoalkoxyalkoxy, alkenyloxyalkoxy, halogenoalkenyloxy, alkoxyalkylthio, alkylthioalkoxy, alkylthioalkylthio, halogenoalkoxycarbonyl, halogenoalkenyloxycarbonyl or dialkylamino or two radicals R.sup.1 when they are positioned ortho to one another together denote a methylenedioxy, ethylenedioxy or alkylene radical,R.sup.2 and R.sup.Type: GrantFiled: April 13, 1988Date of Patent: October 30, 1990Assignee: Hoechst AktiengesellschaftInventors: Hans H. Schubert, Gerhard Salbeck, Hans-Peter Krause, Walter Luders, Werner Knauf, Anna Waltersdorfer, Manfred Kern
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Patent number: 4965284Abstract: This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.Type: GrantFiled: April 25, 1989Date of Patent: October 23, 1990Assignee: American Cyanamid CompanyInventors: Vijay G. Nair, Ramson B. Conrow, Bosco S. Wang, V. M. Ruszala-Mallon
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Patent number: 4963677Abstract: A compound of the formula ##STR1## and pharmaceutically acceptable salts thereof, in which A is --N.dbd.N--NH--, --X--C(R.sub.2).dbd.N--, --N.dbd.C(R.sub.2)--X--, --X--C(R.sub.2)--CH(R.sub.2).dbd.N-- or --N.dbd.C(R.sub.2)--CH(R.sub.2)--X--, wherein X is sulphur, oxygen or nitrogen and R.sub.2 is provided that where two R.sub.2 -groups are present in the A group one of the R.sub.2 groups is hydrogen, amino, substituted amino, C.sub.1-6 alkyl, substituted acylamino or one of the following groups: ##STR2## wherein R.sub.a is hydrogen, amino, substituted amino, C.sub.1-6 alkoxy, heterocyclic five membered ring or --NHCOR', wherein R' is C.sub.1-6 alkyl, aryl or heterocyclic five membered ring, R.sub.b is hydrogen, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio or hydroxy, R.sub.c is hydrogen, C.sub.1-6 alkyl or oxygen and R.sub.d is C.sub.1-6 alkyl or oxygen, R.sub.e is hydrogen, hydroxy or C.sub.1-6 alkoxy, R.sub.f is C.sub.1-6 alkyl, provided that where two R.sub.2 -groups are present in the A group, one of the R.sub.Type: GrantFiled: November 8, 1988Date of Patent: October 16, 1990Assignee: Orion Corporation Ltd.Inventors: Lawrence Sellin, Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Tord K. W. Langenskiold, Irma O. Ojala, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 4963181Abstract: Fungicidal 3-cyano-4-phenyl-pyrrole= derivatives of the formula ##STR1## in which Ar stands for phenyl which is trisubstituted to pentasubstituted andR stands for alkyl, alkoxy or alkoxyalkyl.Claimed are compounds of the formula (I) wherein Ar is phenyl which is trisubstituted by halogen, at least one of which is fluorine, and R is alkyl, alkoxy or alkoxyalkyl each having 1 to 6 carbon atoms in the individual alkyl moieties, fungicidal compositions containing the compounds, and a method of combating fungi comprising administering the compounds to the fungi or their habitat.Type: GrantFiled: April 12, 1989Date of Patent: October 16, 1990Assignee: Bayer AktiengesellschaftInventors: Detlef Wollweber, Wilhelm Brandes, Stefan Dutzmann
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Patent number: 4961877Abstract: A solid silicone defoaming agent which includes a mixture of silicone oil having a viscosity of at least 20 centistokes at 25 degrees Centigrade and microparticulate silica, a copolymer selected from the group consisting of polyoxyalkylene and polyoxyalkylene/polysiloxane copolymers, and a wax selected from the group consisting of a water-insoluble wax which is insoluble in water at room temperature and which has a melting point of at least 35 degrees Centigrade, and a water-soluble wax which dissolves and disperses in water at room temeprature and which has a melting point of at least 30 degrees Centigrade.Type: GrantFiled: August 30, 1988Date of Patent: October 9, 1990Assignee: Dow Corning K.K.Inventors: Hirofumi Shimizu, Ken Morishita
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Patent number: 4960783Abstract: Method of promoting the yield and growth of animals which comprises administering to such animals a yield and growth promoting effective amount of a benzimidazole derivative of the formula ##STR1## in which R.sup.1 stands for hydrogen, hydroxyl, alkyl or halogenoalkyl,R.sup.2 stands for hydrogen, alkyl, halogen, CN or halogenalkyl,R.sup.3 stands for hydrogen, alkyl or acyl,R.sup.4 stands for hydrogen, alkyl or halogenoalkyl,R.sup.5 stands for alkyl or halogenoalkyl,R.sup.6 stands for alkyl or cycloalkyl, which is optionally substituted by halogen, cycloalkyl, OH, alkoxy, halogenoalkoxy or aryl, which can in turn be substituted by alkyl, halogen, CN or the radicals --COR.sup.7, --O--alkylene--COR.sup.7, --alkylene--R.sup.8 or --O-- alkylene--R.sup.8,R.sup.7 stands for hydroxyl, alkoxy or --NR.sup.9 R.sup.10,R.sup.8 stands for hydroxyl, alkoxy or --NR.sup.9 R.sup.10,R.sup.9 stands for hydrogen or alkyl andR.sup.10 stands for hydrogen or alkyl,or physiologically tolerated salts thereof.Type: GrantFiled: December 30, 1988Date of Patent: October 2, 1990Assignee: Bayer AktiengesellschaftInventors: Gerhard Bonse, Werner Hallenbach, Hans Lindel, Friedrich Berschauer
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Patent number: 4959373Abstract: Bispidine derivatives of the formula I ##STR1## where R, R.sup.1 and R.sup.3 are identical or different and are each H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, when Y is ##STR2## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN, C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are each C.sub.1 -C.sub.4 -alkyl, when Y is ##STR3## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN.sub.1 C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.9 R.sup.10 where R.sup.9 is C.sub.1 -C.sub.4 -alkyl and R.sup.10 is H or C.sub.1 -C.sub.4 -alkyl, and when X is not CH.sub.2 R.sub.2 may also be NO.sub.2 or NH.sub.2, X is --CH.sub.2 --, --C(O)-- or --C(R.sup.6)OR.sup.7 -- (where R.sup.6 is H or C.sub.1 -C.sub.4 -alkyl and R.sup.7 is H, C.sub.1 -C.sub.4 -alkyl or ##STR4## where R.sup.8 is H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy), Y is --C(O) or --CONH-- and Z is C.sub.1 -C.sub.Type: GrantFiled: September 22, 1988Date of Patent: September 25, 1990Assignee: BASF AktiengesellschaftInventors: Wilfried Lubisch, Fritz Binnig, Gerda von Philipsborn
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Patent number: 4959092Abstract: The present invention relates to a substituted phenyl(or pyridyl)urea compound and a herbicidal composition containing the substituted phenyl(or pyridyl)urea compound as an active ingredient.The compound has the formula: ##STR1## wherein A represents an alkylene group; B represents a nitrogen atom or CH; R represents a hydrogen atom, a lower alkyl group or a lower alkoxy group;R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent a hydrogen atom or a methyl group; and n is 0 or 1.Type: GrantFiled: May 25, 1988Date of Patent: September 25, 1990Assignee: Mitsubishi Kasei CorporationInventors: Hiroki Ohta, Katsutoshi Sato, Susumu Matsumoto, Kazuo Ishii, Yumiko Miura, Hisao Watanabe, Seiichi Suzuki, Yoichiro Umeki, Hiroshi Hanabe
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Patent number: 4959391Abstract: Phenol derivatives of the formula ##STR1## wherein A and B have the same or different meanings and each represent one of the groups --C.tbd.C--, cis--CH.dbd.CH-- or trans--CH.dbd.CH--, R.sub.1 is hydrogen, an optionally substituted alkyl or phenyl group or a cycloalkyl group, R.sub.2 is hydrogen, methyl or ethyl, R.sub.3 represents hydrogen, acetyl or propionyl, R.sub.4 has the same meaning as R.sub.3 or represents an alkyl group, R.sub.5 is a carboxylic or a hydroxy group or a functional derivative of such groups or R.sub.5 is a nitrile group and R.sub.6 is hydrogen, an alkyl group or the group OR.sub.4 which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The compounds are prepared by reacting suitable acetylene compounds or metal derivatives thereof with alkyl or aryl halides or by means of Wittig reactions optionally followed by transforming the member R.sub.Type: GrantFiled: July 14, 1988Date of Patent: September 25, 1990Assignee: Gruenenthal GmbHInventors: Oswald K. Zimmer, Werner P. Vollenberg, Gerriet K. H. Loschen, Werner Winter, Erwin O. Kiesewetter, Ulrich G. P. Seippl
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Patent number: 4959160Abstract: A process for the resolution of an emulsion which comprises an internal water phase, an external fat and/or oil containing phase and a finely divided metal contaminant which comprises mixing a contaminated emulsion with a volume of water sufficient to increase the total water content to at least 50% on a mass to mass basis, if the water content of the emulsion relative to that of the rest of the emulsion is less than 50% on a mass to mass basis; adding to the emulsion at least one of a suitable emulsifier and demulsifier; mixing the emulsion with a short-chain organic acid to lower the pH from to 3-5 and; allowing the emulsion to settle out into an upper layer comprising the external phase; a lower water layer and a bottom precipitate comprising the contaminant.Type: GrantFiled: April 13, 1988Date of Patent: September 25, 1990Assignees: Iscor Limited, Scientific Construction CC.Inventor: Alan W. Lake
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Patent number: 4956366Abstract: Substituted thienoimidazole derivatives, a process for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammationsThe invention relates to compounds of the formula ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, R.sup.1 to R.sup.10, X, Y and Z have the meanings indicated in the description, to a process for the preparation thereof, to pharmaceutical compositions containing them, and to the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations.Type: GrantFiled: July 13, 1988Date of Patent: September 11, 1990Assignee: Hoechst AktiengesellschaftInventors: Hildegard Nimmesgern, Klaus Weidmann, Hans-Jochen Lang, Robert Rippel, Andreas W. Herling
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Patent number: 4952574Abstract: Certain 2,5-disubstituted N-(2-piperidylmethyl)benzamides, wherein one substituent is 2,2,2-trifluoroethyoxy, and pharmaceutically acceptable acid-addition salts thereof, are active as antiarrhythmic agents.Type: GrantFiled: September 26, 1988Date of Patent: August 28, 1990Assignee: Riker Laboratories, Inc.Inventor: Elden H. Banitt
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Patent number: 4952602Abstract: Biphenyl derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkoxycarbonyl group and R.sup.2 is a lower alkoxycarbonyl group, or R.sup.1 and R.sup.2 are combined together to form a group of the formula: each of R.sup.3 and R.sup.4 is a lower alkoxy group; and Ring A is a substituted or unsubstituted sulfur-containing or nitrogen-containing heterocyclic ring, with the claims being drawn to Ring A as thiophene and a pharmaceutically acceptable salt thereof are disclosed. Said biphenyl derivative (I) and its salt have excellent hypolipidemic activity and are useful for treatment or prophylaxis of hyperlipidemia and/or arterioscelerosis.Type: GrantFiled: November 8, 1988Date of Patent: August 28, 1990Assignee: Tanabe Seiyaku Company, Ltd.Inventors: Tameo Iwasaki, Kohki Takashima
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Patent number: 4950420Abstract: An antifoam/defoamer composition a polyether surfactant and a polyhydric alcohol fatty acid ester. The polyether surfactant being admixed with the polyhydric alcohol fatty acid ester in a ratio in the range between 10:90 to 90:10% by weight.Type: GrantFiled: August 25, 1989Date of Patent: August 21, 1990Assignee: Nalco Chemical CompanyInventor: James J. Svarz
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Patent number: 4950668Abstract: A novel pyrazole derivative and an insecticidal or miticidal composition containing the derivative as the effective ingredient are disclosed.The pyrazole derivative of the present invention has an excellent controlling effect also against harmful insects and mites exhibiting resistance to conventional insecticides and does not disturb the ecosystem since it is less toxic and less residual.Type: GrantFiled: April 14, 1988Date of Patent: August 21, 1990Assignee: Mitsubishi Kasei CorporationInventors: Itaru Okada, Shuko Okui, Yoji Takahashi, Toshiki Fukuchi
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Patent number: 4931223Abstract: Processes are disclosed in which light of different wavelengths is simultaneously released from two or more enzymatically decomposable chemiluminescent 1,2-dioxetane compounds, said compounds being configured, by means of the inclusion of a different light emitting fluorophore in each of them, to each emit light of said different wavelengths, by decomposing each of said compounds by means of a different enzyme. Such processes can be used in multi-channel assays--immunoassays, chemical assays and nucleic acid probe assays--to detect the presence or determine the concentration of chemical or biological substances, and in multi-channel chemical/physical probe procedures for studying the microstructures of macromolecules.Type: GrantFiled: June 30, 1988Date of Patent: June 5, 1990Assignee: Tropix, Inc.Inventors: Irena Y. Bronstein, John C. Voyta