Patents Examined by Cecila Tsang
  • Piperazine Derivatives
    Patent number: 5541326
    Abstract: Piperazine derivatives of formula: ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula, n is 1 or 2; R and R.sup.5 are hydrogen or lower alkyl, R.sup.1 is substituted or unsubstituted aryl or a heteroaromatic radical; R.sup.3 is substituted or unsubstituted aryl or substituted or unsubstituted arylalkyl; R.sup.9 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl or substituted or unsubstituted arylalkyl with the proviso that when R.sup.9 is hydrogen, alkyl, or arylalkyl, R.sup.5 is other than a tertiary alkyl group. The compounds of this invention are useful 5-HT.sub.1A antagonists for the treatment of CNS disorders such as anxiety.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: July 30, 1996
    Assignee: John Wyeth & Brother, Limited
    Inventor: Ian A. Cliffe
  • Acetylene derivatives, process for producing the same, liquid crystal composition containing the same as an active ingredient, and liquid crystal element using said liquid crystal composition
    Patent number: 5534188
    Abstract: An acetylene derivative represented by general formula (I): ##STR1## wherein R.sup.1 is saturated or unsaturated alkyl group having 3-20 carbon atoms, R.sup.2 is saturated or unsaturated alkyl group having 1-20 carbon atoms which may optionally be substituted by halogen atom or alkoxyalkyl group having 2-20 carbon atoms, A and B represent phenylene group or the like or taken as --A--B-- represent naphthalene group or the like, m and s are each 0 or 1, n is integer of 1-6, and * means asymmetric carbon atom; a process for producing said acetylene derivative, a liquid crystal composition using the same as active ingredient, and a liquid crystal element using said composition.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: July 9, 1996
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masayoshi Minai, Takayuki Higashii, Shoji Toda, Naoyuki Takano, Kayoko Ueda, Koichi Fujisawa
  • Method of making oxydiphthalic anhydride
    Patent number: 5336788
    Abstract: Disclosed is a method of making oxydiphthalic anhydride from oxydiphthalic acid. The oxydiphthalic acid is mixed with an organic liquid that codistills with water and the resulting slurry is heated to the boiling point of the slurry to remove any water. About 1 to about 4 moles of acetic anhydride per mole of oxydiphthalic acid are added to the slurry and the slurry is heated to a temperature between 50.degree. and 160.degree. C. until the oxydiphthalic acid content thereof is less than 0.1 weight percent. The slurry is filtered and the filter cake is heated to a temperature between about 180.degree. C. and below its melting point for about 12 to about 24 hours.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: August 9, 1994
    Assignee: Occidental Chemical Corporation
    Inventor: Viesturs Lesins