Abstract: 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]m ethoxy]phenyl]-1-piperazinyl]phenyl]triazolones, their pharmaceutically acceptable acid addition salts and stereoisomeric forms having improved antimicrobial properties, compositions containing the same, and methods of inhibiting and/or eliminating the development of fungi and bacteria in warm-blooded animals suffering from diseases caused by these fungi and/or bacteria.
Type:
Grant
Filed:
April 7, 1989
Date of Patent:
April 10, 1990
Assignee:
Janssen Pharmacuetica N.V.
Inventors:
Jan Heeres, Leo J. J. Backx, Louis J. E. Van der Veken