Abstract: An oxygen-containing cyclicfluoro compound selected from the group consisting of a perfluorolactone having the formula ##STR1## a perfluorocyclic ether having the formula ##STR2## and mixtures thereof is produced by reacting an .alpha.,.omega.-diiodoperfluoroalkane having the formulaI (CF.sub.2).sub.n Iwith fuming sulfuric acid, wherein n is all formulas ranges from 3 to 5.
Abstract: The levorotatory enantiomers of 3-loweralkoxy-cyproheptadines are potent antiserotonin agents with a lower order of antihistaminic activity and substantially free of any anticholinergic activity. They are prepared by treatment of the levorotatory enantiomer of 3-iodocyproheptadine with an alkali metal lower alkoxide in the presence of copper powder.
Abstract: A perfluorolactone having the formula ##STR1## wherein n is an integer of 2 to 4, is produced by reacting a fluoro compound having the formulaI(CF.sub.2).sub.n COXwherein n is an integer of 2 to 4 and X represents a halogen atom, --OR or --NR.sup.1 R.sup.2, and R, R.sup.1 and R.sup.2 respectively represent hydrogen atom or a C.sub.1 - C.sub.10 alkyl group, with fuming sulfuric acid.
Abstract: N-(5,7-Dibromo-1,3-benzoxathiol-2-ylidene)-N-methylmethanaminium bromide and the analogous diodo iodide, new compounds, are prepared by the thermal rearrangement of O-(2,4,6-tribromophenyl)-N,N-dimethylthiocarbamate and O-(2,4,6-triiodophenyl)-N,N-dimethylthiocarbamate. The first-named compound has antimicrobial utility. Both compounds are useful as starting materials for the preparation of bis-(3,5-dibromo-2-hydroxyphenyl)disulfide and 2,4-diiodo-6-mercaptophenol, respectively, by hydrolysis of the two first-named compounds with methanolic sodium hydroxide. Both the disulfide and the mercaptophenol compounds have antimicrobial utility.
Type:
Grant
Filed:
March 24, 1977
Date of Patent:
May 2, 1978
Assignee:
The Dow Chemical Company
Inventors:
Charles E. Reineke, Christian T. Goralski
Abstract: Phenyl-substituted perfluoroalkanesulfonanilides in which the phenyl rings are linked by sulfur, sulfinyl or sulfonyl and salts thereof in which the rings and the perfluoroalkylsulfonamido nitrogen are optionally substituted. The compounds are active herbicides and some are anti-inflammatory agents and analgesic agents.
Type:
Grant
Filed:
January 10, 1977
Date of Patent:
April 25, 1978
Assignee:
Minnesota Mining and Manufacturing Company
Inventors:
George G. I. Moore, Joseph Kenneth Harrington
Abstract: 1,3-Benzodithiole-2-one and 1,3-benzodithiole-2-thione compounds are disclosed including the novel method of preparing said compounds and their biocidal activity.
Abstract: A method for producing a 3,3-dimethyl-4-(2,2-dihalogenovinyl)-4-hydroxybutyric-1,4-lactone of the formula, ##STR1## wherein X is a halogen atom, which comprises reacting a 1,1,1-trihalogeno-4-methyl-3-pentene-2-ol of the formula, ##STR2## wherein X is a halogen atom, or a 1,1,1-trihalogeno-4-methyl-4-pentene-2-ol of the formula, ##STR3## wherein X is a halogen atom, or the mixture of the both compounds with vinylidene chloride of the formula, ##STR4## IN SULFURIC ACID.
Abstract: 16-Oxa- and 16-thia-D-homo-estrogen derivatives useful as postcoital oral contraceptives which are produced by total synthesis from 1-vinyltetralin-1-ols or their thiuronium derivatives on reactions with 4-substituted tetrahydropyran- or tetrahydrothiopyran-3,5-diones, and subsequent appropriate modifications.
Abstract: Treating compounds of the formula ##STR1## in which the nuclei marked "A" and "B" can be substituted by halogen, lower alkyl, lower alkoxy or phenyl, with acid binding agents at elevated temperatures in polar organic solvents yields compounds of the formula ##STR2## in which A and B have the same meaning. The products are dyestuffs of high brillancy, pure shades, high fluorescence, excellent tinctorial strength and good fastness to light.
Abstract: There are described novel charge transfer compounds having high electrical conductivity which are represented by the formula [A].sub.x.sup.+ [B].sub.y.sup.- where A is represented by the formula ##STR1## where R.sub.1 -R.sub.4 may be the same or different and may be H or CH.sub.3 and B is 7,7,8,8-tetracyanoquinodimethane, X is 1 and Y is 1 or 2.
Abstract: Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyls or alkenyls having 1 to 4 atoms or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, and RX is a salt-forming moiety. The compounds are prepared by reacting 2-acetyl benzothiophene with ##STR3## The compounds possess a blood plaque aggregation inhibiting property and also possess spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vasodilatatory properties.
Abstract: Novel substituted azabicycloalkanes and methods of preparing the same are disclosed. These compounds are useful as analgetic agents which exhibit a tendency towards low physical dependence.
Abstract: Novel N-tricyclic derivatives of azetidine are disclosed of the general formula: ##STR1## WHERE A is a --CH.sub.2 --S-- or --S--CH.sub.2 -- group, the remaining substituents being defined in the specification. Illustrative is the compound 1-[11-(6,11-dihydro-dibenzo [b,e] thiopinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
Type:
Grant
Filed:
November 2, 1976
Date of Patent:
March 7, 1978
Assignee:
Carlo Erba S.p.A.
Inventors:
Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
Abstract: 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.This is a division of application Ser. No. 611,282 filed Sept. 8, 1975.
Type:
Grant
Filed:
January 25, 1977
Date of Patent:
February 28, 1978
Assignee:
Warner-Lambert Company
Inventors:
David T. Connor, Patricia A. Young, Maximilian VON Strandtmann
Abstract: Novel compounds of the formula: ##STR1## wherein R is a hydrogen or fluorine atom, W is an oxygen atom or an ethylenedioxy or ethylenedithio group and Z is a certain secondary amino group, which are useful as central nervous system depressants, can be prepared by the reaction of a compound of the formula: ##STR2## wherein X is a halogen atom and R and W are each as defined above with a secondary amine of the formula: H--Z wherein Z is as defined above, in case of W being ethylenedioxy or ethylenedithio, optionally followed by hydrolysis and can be reduced to give a compound of the formula: ##STR3## wherein R and Z are each as defined above, which are useful as antipsychotic and/or analgesic agents.
Abstract: Decahydro-3,3,8,8-tetramethoxy-2,7-epithio-1,4-ethanonaphthalene-5,9-dione, decahydro-3,3,8,8-tetraethoxy-2,7-epithio-1,4-ethanonaphthalene-5,9-dione, decahydro-dispiro[1,3-dioxolane-2,3'-(2',7'-epithio-1',4'-ethanonaphthalen e)-8',2"-[1,3]dioxolane]-5',9'-dione have been found to be effective as secondary antioxidants for polyolefins.
Abstract: A novel class of dithiane and disulfone compound is described. These compounds are pharmaceutically active as coronary dilating agents and thus can be used therapeutically in cases of insufficient cardiac blood supply, i.e., in the treatment of angina pectoris. A preferred compound is N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithiane-2-p ropylamine-1,1-3,3-tetraoxide.
Abstract: 2-Oximino-1,3,5-trithiane compounds are useful intermediates in the preparation of 1,3,5-trithiane carbamoyloxime compounds which exhibit outstanding pesticidal activity.
Type:
Grant
Filed:
June 1, 1976
Date of Patent:
February 14, 1978
Assignee:
Union Carbide Corporation
Inventors:
Arthur P. Kurtz, Jr., Themistocles D. J. D'Silva