Patents Examined by Cecilia Shen
  • Patent number: 5212312
    Abstract: Dyes of the formula ##STR1## in which F is the radical of an indigoid dye, of a benzothioxanthene or of an aromatic dye which contains at least 4 alicyclic and/or heterocyclic, fused six-membered rings and at least two ring keto groups and is not water-soluble, R.sub.1 is a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted cycloalkyl radical, a substituted or unsubstituted aryl radical or a radical of the formula--A--Qwhere A is a substituted or unsubstituted C.sub.1-4 -alkylene radical and Q is a basic radical, which may be quaternised, and R.sub.2 is hydrogen or a substituted or unsubstituted C.sub.1-4 -alkyl radical, or in which R.sub.1 and R.sub.2 together with the ##STR2## group are a phthalimide radical, and R.sub.3 is hydrogen, a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted aryl radical, a C.sub.1-4 -alkoxycarbonyl radical or a N,N-di-C.sub.1-4 -alkylcarboxamide radical and n is 1, 2, 3 or 4.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: May 18, 1993
    Assignee: Ciba-Geigy AG
    Inventors: Jean-Marie Adam, Athanassios Tzikas
  • Patent number: 5185446
    Abstract: This invention encompasses compounds of the formula: ##STR1## and pharmaceutically acceptable non-toxic salts thereof wherein n is 0,1 or 2 and X is --N.dbd.C--R.sub.9 or NR.sub.10 --C.dbd.Twhere R.sub.1, R.sub.2, R.sub.3, and R.sub.9 and R.sub.10 and X, Y, W and T are variables.These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdoes with benzodiazepine type drugs, and enhancement of alertness.
    Type: Grant
    Filed: September 4, 1990
    Date of Patent: February 9, 1993
    Assignee: Neurogen Corporation
    Inventors: Kenneth Shaw, Alan J. Hutchison
  • Patent number: 5179104
    Abstract: An asymmetric process for the preparation of enantiomerically pure .beta.-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of the nucleosides. The anti-viral activity of the compounds is surprising in light of the generally accepted theory that moieties in the endo conformation, including these dioxolanes, are not effective antiviral agents. The toxicity of the enantiomerically pure dioxolane nucleosides is lower that that of the racemic mixture of the nucleosides, because the nonnaturally occurring .alpha.-isomer is not included.The product can be used as a research tool to study the inhibition of HIV in vitro or can be administered in a pharmaceutical composition to inhibit the growth of HIV in vivo.
    Type: Grant
    Filed: December 5, 1990
    Date of Patent: January 12, 1993
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Chung K. Chu, Raymond F. Schinazi
  • Patent number: 5143917
    Abstract: The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration ()CMC) in the order of 10.sup.-5 -10.sup.-7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components have pharmacological activities and can act as antimetabolites.
    Type: Grant
    Filed: May 24, 1990
    Date of Patent: September 1, 1992
    Assignee: Medice Chem.-Pharm. Fabrik Putter GmbH & Co. KG
    Inventor: Henrich H. Paradies
  • Patent number: 5142053
    Abstract: The invention relates to a process for the preparation of the compound of formula I: ##STR1## characterized in that 2,3,4-trimethoxybenzaldehyde is dissolved with piperazine, and then the reaction medium is subjected to the action of hydrogen to give the compound of formula I.
    Type: Grant
    Filed: April 19, 1991
    Date of Patent: August 25, 1992
    Assignee: Adir et Compagnie
    Inventor: Jean-Claude Souvie
  • Patent number: 5135931
    Abstract: Disclosed are compounds displaying improved preferential serotonin-1A binding activity. The claimed compounds have the formula: ##STR1## wherein R.sub.1 is selected from the group consisting of hydroxy, halogen, lower alkyl, lower alkoxy, and hydrogen;R.sub.2 is hydrogen or lower alkyl;X is CH or a nitrogen atom;ALK is a saturated, branched or unbranched, aliphatic hydrocarbon having from 1 to 7 carbon atoms; andZ is selected from the group consisting of hydrogen, halogen, hydroxy, trifluoromethyl, or lower alkyl;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 10, 1991
    Date of Patent: August 4, 1992
    Assignee: Akzo N.V.
    Inventors: Patrick Carlier, Claude Poisson, Andre Monteil
  • Patent number: 5133973
    Abstract: The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration (CMC) in the order of 10.sup.-5 -10.sup.-7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components have pharmacological activities and can act as antimetabolites.
    Type: Grant
    Filed: May 24, 1990
    Date of Patent: July 28, 1992
    Assignee: Medice Chem.-Pharm. Fabrik Putter GmbH & Co. KG
    Inventor: Henrich Paradies
  • Patent number: 5132425
    Abstract: Novel quaternary ammonium compounds of formula (1) and (2): ##STR1## wherein R represents a straight or branched alkylene group containing from 2 to 24 carbon atoms, an alicyclic alkylene group, an aralkylene group or a group of the formula --CH.sub.2 CH.sub.2 O).sub.p (CH.sub.2 CH.sub.2).sub.q (in which p and q each represents a positive integer), R' represents a straight or branched alkyl group containing from 1 to 24 carbon atoms, an alkenyl group or an aralkyl group, R" represents an alkyl group containing 1 to 5 carbon atoms or an aralkyl group, X.sup.- represents an anionic group and n represents a positive integer of from 2 to 50 are disclosed. The quaternary ammonium compounds are useful as surfactants capable of serving as softening agents and antistatic agents for fabrics, hair and the like.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: July 21, 1992
    Assignee: Kao Corporation
    Inventors: Kohshiro Sotoya, Uichiro Nishimoto, Hiroshi Abe
  • Patent number: 5129938
    Abstract: A herbicidal pyrimidine derivative having the formula, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y.sub.1, Y.sub.2, Y.sub.3, X and Z are defined as in the specification.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: July 14, 1992
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Mitsunori Hiratsuka, Naonori Hirata, Kazuo Saitoh, Hideyuki Shibata
  • Patent number: 5127935
    Abstract: Disclosed herein is uracil derivatives having a haloalkyl group at the 5-position and a phenyl group at the 2-position which has a specific substituent, which are represented by the formula (I) and showing penetrative translocation activity and a very high herbicidal activity, in which as compared with the conventional herbicidal compounds, the said uracil derivatives can be applied for either soil treatment or foliage treatment, thereby producing a quick and high herbicidal effect even at a very low dosage against a large variety of weeds including perennial weeds, and have the property to residual effect for an appropriate period of time.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: July 7, 1992
    Assignee: Nissan Chemical Industries Ltd.
    Inventors: Jun Satow, Kenzou Fukuda, Kaoru Itoh, Koichi Suzuki, Tsutomu Nawamaki, Shigeomi Watanabe
  • Patent number: 5128348
    Abstract: Certain hexane and heptane amines including geometric and stereoisomers, agricultural compositions containing them and their use as fungicides.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: July 7, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Gregory S. Basarab
  • Patent number: 5126350
    Abstract: A compound represented by the formula I: ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen or (C.sub.2 -C.sub.10) alkanoyl in substantially chemically pure form, and pharmaceutical compositions thereof are disclosed.
    Type: Grant
    Filed: June 13, 1990
    Date of Patent: June 30, 1992
    Assignee: Schering Corporation
    Inventors: Raymond Cooper, Ann C. Horan, Joseph A. Marquez, Mahesh G. Patel
  • Patent number: 5126463
    Abstract: This invention provides a process for the production of an anhydride by the vapor phase reaction of a hydrocarbon with substantially pure oxygen in the presence of a suitable catalyst. In the improved process, the anhydride product is removed, carbon monoxide, present in the reactor effluent as a by-product, is oxidized to carbon dioxide and part of the gaseous effluent, comprised mainly of carbon dioxide and unreacted hydrocarbon, is recycled to the reactor. Removal of carbon monoxide from the recycle stream reduces the hazard of a fire or explosion in the reactor or associated equipment. The use of carbon dioxide as the principal diluent increases heat removal from the reactor, thereby increasing the production capacity of the reactor.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: June 30, 1992
    Assignee: The BOC Group, Inc.
    Inventors: Ramakrishnan Ramachandran, Arthur I. Shirley, Lien-Lung Sheu
  • Patent number: 5126443
    Abstract: Compounds of the formulae ##STR1## salts thereof, and mixtures of such compounds or salts,wherein Me, Pc, Q.sub.1, R.sub.1, R.sub.2, R.sub.3, Y, a, b, c and d as defined,useful as fiber-reactive dyes for dyeing or printing hydroxy group- and nitrogen-containing organic substrates, for example, textile material comprising cotton, the obtained dyeings and prints having good all-round fastnesses, such as good light fastness.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: June 30, 1992
    Assignee: Sandoz Ltd.
    Inventors: Helmut A. Moser, Roland Wald
  • Patent number: 5124332
    Abstract: Substituted indoles and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: June 23, 1992
    Assignee: Warner-Lambert Company
    Inventors: Lawrence D. Wise, David J. Wurtrow
  • Patent number: 5124442
    Abstract: The present invention relates to a process for preparing a compound of formula I ##STR1## from a compound of formula II ##STR2## via a compound of formula IV ##STR3## and to a compound of formula IV by way of an intermediate in the preparation of a compound of formula I.
    Type: Grant
    Filed: October 25, 1990
    Date of Patent: June 23, 1992
    Assignee: Universite Pierre et Marie Curie (Paris VI)
    Inventors: Stanislas Czernecki, Jean-Marc Valery
  • Patent number: 5124324
    Abstract: Disclosed are compounds of formula I ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, benzyl or an indolyl carbonyl group, R.sub.2 is a saturated or unsaturated 5- or 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C.sub.1 -C.sub.6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain --(CH.sub.2).sub.n -- are optionally substituted by a C.sub.1 -C.sub.6 alkyl, phenyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.
    Type: Grant
    Filed: November 16, 1990
    Date of Patent: June 23, 1992
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Makoto Yanai, Toshio Suguro, Koichiro Hagihara
  • Patent number: 5124331
    Abstract: 3,4-Dihydrothieno[2,3-d]pyrimidine compounds having immunoregulating and carcinostatic actions of the general formula ##STR1## wherein A represents a C.sub.1-4 alkylene; R.sup.1 represents hydrogen, an alkyl, an aryl which may be substituted or --N(R.sup.7)(R.sup.8); R.sup.2, R.sup.3 and R.sup.4 represent hydrogen, a halogen, hydroxy, an alkyl which may be substituted by a halogen, an alkoxy, nitro, cyano or --N(R.sup.9)(R.sup.10); R.sup.5 represents hydrogen, a halogen, nitro, amino, cyano, an alkyl or an alkoxycarbonyl; R.sup.6 represents hydrogen, a halogen, nitro, amino, cyano, an alkyl, an alkoxycarbonyl, a halogenosulfonyl or --SO.sub.2 N(R.sup.12)(R.sup.13); or R.sup.5 and R.sup.6 may, taken together, form a C.sub.3-6 alkylene chain, and their pharmaceutical use.
    Type: Grant
    Filed: November 2, 1989
    Date of Patent: June 23, 1992
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Masafumi Arita, Yoshitaka Fukumasu, Mitsuharu Sano, Yukio Hoshino, Hirotsugu Komatsu
  • Patent number: 5122617
    Abstract: Tetracarboxylic acid anhydrides represented by the following formulae [IA] and [IB] are provided: ##STR1## where n is an integer of 1 to 3. The tetracarboxylic acid anhydrides give polyimides having low thermal expansion, low dielectric constant and low hygroscopicity.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: June 16, 1992
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventor: Koji Okada
  • Patent number: 5120738
    Abstract: Compounds represented by general formula (I) below ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;R.sup.3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C.sub.5 .about.C.sub.25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula ##STR2## where R.sup.4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C.sub.5 .about.C.sub.25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, andR.sup.5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrovarbon group which may be substituted with an aromatic group;Q represents(a) a group of formula --X.sup.1 --A--Y.sup.1 --, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C.sub.2 .about.C.sub.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: June 9, 1992
    Assignee: Fujirebio Inc.
    Inventors: Hiroshi Ikawa, Hajime Matsumoto, Nobuo Kobayashi, Jun Kusunoki