Patents Examined by Cecilia Tsang
  • Mussel bioadhesive
    Patent number: 7622550
    Abstract: The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a hybrid of MGFP-5 and foot protein type 1 (FP-1), where an adhesive protein with adhesive activity can be economically mass-produced to be used in place of chemical adhesives through the present invention.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: November 24, 2009
    Assignees: Postech Foundation, POSCO
    Inventors: Hyung Joon Cha, Dong Soo Hwang
  • Bimolecular optical probes
    Patent number: 7619059
    Abstract: Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically include a peptide, a first detectable moiety, a first binding member, and a protease cleavage site. Modification of a composition by a post-translational modification enzyme, such as a kinase or phosphatase, alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition when it is associated noncovalently with a probe composition that includes a second binding member and a second detectable moiety. Panel assays for determining substrates or modulators of enzymatic activities are also described.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: November 17, 2009
    Assignee: Life Technologies Corporation
    Inventors: Kevin R. Kupcho, Kurt Vogel, Elizabeth A. Werner, Jane A. Beebe, Tony A. Klink, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
  • Peptidomimetic polymers for antifouling surfaces
    Patent number: 7618937
    Abstract: Peptidomimetic polymers comprising one or more DOPA moieties and related coatings and composites.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: November 17, 2009
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Annelise Barron, Andrea Statz, Robert Meagher
  • Heteroaryl peptidomimetics as thrombin receptor antagonists
    Patent number: 7618945
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: November 17, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, William J. Hoekstra, Kimberly White
  • Encapsulated amyloid-beta peptides
    Patent number: 7618944
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: November 17, 2009
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Habib Skaff, Kevin N. Sill
  • Plastic implant impregnated with a degradation protector
    Patent number: 7615075
    Abstract: A plastic implant device for a mammal that contains a rare earth metal compound tracer and a method for detecting degradation such as wear of the implanted device are disclosed. The tracer can also be present with a separate antioxidant or the tracer compound can be can be the salt of a C6-C22 unsaturated carboxylic acid. The rare earth metal compound tracer is released when the prosthetic is worn down or otherwise degraded in the mammalian body in which it was implanted. The presence and amount of released tracer present in a body fluid or tissue sample measured and is proportional to the degree of degradation of the implant.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: November 10, 2009
    Assignee: Rush University Medical Center
    Inventors: Achim Kunze, Markus Wimmer
  • Immunogenic compositions and methods of use
    Patent number: 7615530
    Abstract: Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: November 10, 2009
    Assignee: Artificial Cell Technologies, Inc.
    Inventor: Donald T. Haynie
  • TPO peptide compounds for treatment of anemia
    Patent number: 7615533
    Abstract: Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: November 10, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Edward J. Yurkow, Brian R. MacDonald, Jeffery K. Weis
  • Treatment of endometriosis
    Patent number: 7615210
    Abstract: A method of combating menorrhagia, dysmenorrhoea or endometriosis in a female individual that includes administering to the individual at least one agent that reduces the effect of prokineticin 1 on a prokineticin receptor.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: November 10, 2009
    Assignee: Medical Research Council
    Inventors: Henry Nicolas Jabbour, Robert Peter Millar
  • Cardiac muscle function and manipulation
    Patent number: 7612164
    Abstract: This invention relates to polypeptides which affect myocardial cell differentiation and organisation of cardiac muscle contractile units, assay for identifying such polypeptides, and methods for improving cardiac function by the administration of such polypeptides to patients with heart disease. In one aspect, the invention provides a therapeutic composition comprising a peptide consisting of a fragment of human neuregulin ?2 isoform containing the EGF-like domain, e.g., SEQ ID NO.:2, and a physiologically acceptable carrier, excipient or stabilizer.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: November 3, 2009
    Assignee: Zensun (Shanghai) Science and Technologies Ltd.
    Inventor: Mingdong Zhou
  • Methods for delivering compounds into a cell
    Patent number: 7612033
    Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: November 3, 2009
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas McCreery
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7612037
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: November 3, 2009
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel D. Long, Daniel Marquess, Edmund J. Moran, Matthew B. Nodwell, S. Derek Turner, James Aggen
  • Peptoid compounds
    Patent number: 7612036
    Abstract: The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compositions thereof.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: November 3, 2009
    Assignee: University of Wollongong
    Inventors: John Bremner, Stephen Pyne, Paul Keller, Dan Coghlan, Adel Garas, Helen Witchhard, Tim Boyle, Jonathan Coates
  • Method for treating oncological diseases
    Patent number: 7612032
    Abstract: A method to treat solid tumors and other oncological diseases consists of parenterally injecting an agent which destroy's blood's extracellular DNA into the systemic blood circulation of a cancer patient to slow down malignant. The agent is embodied in the form of a DNAse enzyme and, more particularly, as a bovine pancreatic DNAse. Doses from 50,000-250,000,000 Kunz units/day are injected for 5-360 days. A binding agent or an agent that modifies the chemical composition of the blood extracellular DNA is additionally injected into the blood. This modifying agent is preferably an enzyme-ribonuclease.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: November 3, 2009
    Inventors: Dmitry Dmitrievich Genkin, Viktor Veniaminovich Tets, Gregory Viktorovich Tets
  • Solid-phase synthesis is a capillary
    Patent number: 7612165
    Abstract: The invention provides, inter alia, methods for synthesizing a molecule on the channel surface of a capillary, comprising the steps of: (i) covalently attaching a first chemical entity to the channel surface of a capillary; and (ii) covalently attaching a second chemical entity to the first chemical entity, wherein the covalent attachment steps are part of a process for synthesizing a molecule on the channel surface.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: November 3, 2009
    Assignee: PhyNexus, Inc.
    Inventor: Douglas T. Gjerde
  • Use of acid stable protease in animal feed
    Patent number: 7608444
    Abstract: The present invention relates to acid-stable proteases of the subtilisin family, their use in animal feed, feed-additives and feed compositions containing such proteases, and methods for the treatment of vegetable proteins using such proteases.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: October 27, 2009
    Assignee: DSM IP Assets B.V.
    Inventors: Peter Rahbek Oestergaard, Carsten Sjoeholm, Anna-Marie Kluenter
  • Delivery vehicle comprising a modified MscL protein channel
    Patent number: 7608582
    Abstract: The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: October 27, 2009
    Assignee: Applied NanoSystems B.V.
    Inventors: Armagan Kocer, Martin Walko, George Thomas Robillard
  • Process for the extraction and isolation of insulin from recombinant sources
    Patent number: 7608583
    Abstract: The present invention relates to the extraction and isolation of insulins from recombinant sources, particularly those expressed in and secreted by yeasts. Organic solvents have been used to extract host surface bound forms of insulin polypeptide. In addition, procedures for combining the steps medium clarification, solvent extraction and chromatography, in order to effect the simultaneous isolation and purification of soluble and membrane bound forms of insulin, is disclosed.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: October 27, 2009
    Assignee: Wockhardt Limited
    Inventors: Maharaj K Sahib, Edupuganti B Raju, Umesh S Shaligram
  • Apparatus for ultrasonic microbial disruption
    Patent number: 7608440
    Abstract: Apparatus for microbial disruption, comprises a cylindrical transducer having a beat conducting, solid transmission layer disposed along at least a part of the inner longitudinal surface thereof, said transmission layer or said transducer and transmission layer defining a channel for receipt of a liquid sample, and means capable of delivering an alternating potential to said transducer at a frequency and voltage exciting resonance and inducing cavitation in said liquid sample.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: October 27, 2009
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: William Terence Coakley, Kathryn Amelia Jane Borthwick, Martin Bernard McDonnell, Tracey Elizabeth Love
  • Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
    Patent number: 7608580
    Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: October 27, 2009
    Assignees: Genetics Institute, LLC, Fidia Advanced Biopolymers S.R.L.
    Inventors: Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney