Patents Examined by Ceila Chang
  • Patent number: 7078563
    Abstract: A process for the oxidation of a C2 to C4 alkane to produce the corresponding alkene and carboxylic acid which process comprises contacting in an oxidation reaction zone, said alkane, molecular oxygen-containing gas, and the corresponding alkene and optionally, water, in the presence of at least one catalyst active for the oxidation of the alkane to the corresponding alkene and carboxylic acid, to produce a product stream comprising alkene, carboxylic acid and water, wherein in said process the molar ratio of alkene to carboxylic acid produced in said oxidation reaction zone is adjusted or maintained at a pre-determined value by controlling the concentrations of the alkene and optional water in said oxidation reaction zone and optionally by also controlling one or more of the pressure, temperature and residence time of the oxidation reaction zone. Such an oxidation process may be used in an integrated process, such as for the manufacture of vinyl acetate or ethyl acetate.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: July 18, 2006
    Assignee: BP Chemicals Limited
    Inventors: Brian Ellis, Andrew Richard Lucy, Mark Stephen Roberts
  • Patent number: 7049451
    Abstract: A carrier for use in the catalyst for the production of an epoxide is obtained by preparing a carrier precursor containing (a) ?-alumina, (b) silicon or a compound thereof, and (c) at least one element selected from the class consisting of germanium, tin, lead, phosphorus, antimony, and bismuth or a compound thereof and subsequently heat-treating the precursor in non-oxidative gas. The catalyst for the production of the epoxide is obtained by having silver deposited on this carrier and the epoxide is obtained from a corresponding unsaturated hydrocarbon of 2–4 carbon atoms with a high selectivity by using the catalyst.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: May 23, 2006
    Assignee: Nippon Shokubai, Co., Ltd.
    Inventors: Toshiya Ehara, Hitoshi Takada
  • Patent number: 7030262
    Abstract: Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: April 18, 2006
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Jack Henkin, Megumi Kawai, Xenia B. Searle, George S. Sheppard, Jieyi Wang
  • Patent number: 6967209
    Abstract: A process for preparing 6-hydroxy-3,4-dihydroquinolinone by intramolecular Friedel-Crafts alkylation of N-(4-methoxyphenyl)-3-chloropropionamide in which an equivalent of N-(4-methoxyphenyl)-3-chloropropionamide is contacted with a Lewis acid in DMSO or a high boiling amide or amine at an elevated temperature of from about 150° C. to about 220° C. is provided. The process produces 6-HQ in high yield and a high state of purity such that it may be used in subsequent reactions toward the preparation of cilostazol without intermediate purification. A process for preparing cilostazol from 6-hydroxy-3,4-dihydroquinolinone prepared by the process and improved processes for preparing N-(4-methoxyphenyl)-3-chloropropionamide are also provided.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: November 22, 2005
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Marioara Mendelovici, Gideon Pilarsky, Tamar Nidam, Ben-Zion Dolitzky
  • Patent number: 6962997
    Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: November 8, 2005
    Assignee: Celgene Corporation
    Inventors: Vikram Khetani, Yalin Luo, Sowmianarayanan Ramaswamy
  • Patent number: 6953856
    Abstract: A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine hydrochloride (Donepezil HCl) is disclosed. 5,6-Dimethoxy-2-(pyridin-4-yl) methylene inda-1-one is hydrogenated with a noble metal catalyst or a non-oxide derivative of a noble metal catalyst in a solvent at 20-100° C. and 10-90 psi gauge pressure. The resulting 4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine is alkylated with an alkylating agent in an organic solvent at 20-80° C.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: October 11, 2005
    Assignee: USV, Limited
    Inventors: Tarur Venkatasubramanian Radhakrishnan, Sathe Dhanajay Govind, Naidu Avinash Venkatraman
  • Patent number: 6924294
    Abstract: The present invention provides novel compounds of Formula (I), or the pharmaceutically acceptable salts or prodrugs thereof, and methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: August 2, 2005
    Assignee: Eli Lilly and Company
    Inventors: Thomas John Bleisch, Ana Maria Castano Mansanet, Esteban Dominguez-Manzanares, Ana Maria Escribano
  • Patent number: 6919476
    Abstract: A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: July 19, 2005
    Assignee: Credia Japan Co., Ltd.
    Inventors: Hisafumi Ikeda, Isao Saito, Yushin Nakamura
  • Patent number: 6906197
    Abstract: A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a) wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a is typically a hydrocarbon group having at least one oxo group and optionally having other substituent, with an optically active amine of Formula (2): wherein R3 is an unsubstituted or substituted aryl group; R4 is an unsubstituted or substituted lower alkyl group; and C1 is an asymmetric carbon atom, in the presence of an organic acid to thereby yield a corresponding optically active imine, hydrogenating the imine in the presence of a catalyst to yield a corresponding amine, subjecting the amine or its salt to hydrogenolysis in the presence of a catalyst, and reducing the hydrogenolyzed product with a reducing agent.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: June 14, 2005
    Assignee: Daicel Chemical Industries, Ltd
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura
  • Patent number: 6906089
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are various substituent groups; and one of X1 and X2 is N or CR?, and the other is NR? or CHR? wherein R? is hydrogen, OH, C1-6alkyl, or C3-7cycloalkyl; or when one of X1 and X2 is N or CR? then the other may be S or O; and their use as pharmaceuticals.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: June 14, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Laramie Mary Gaster, John David Harling
  • Patent number: 6906104
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 14, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Patent number: 6903209
    Abstract: Disclosed is a polyuronic acid having an average degree of polymerization less than 20. The method of the present invention comprises the steps: (a) providing a solution containing 5 wt. % or more of a high molecular weight polyuronic acid predominantly as its lithium salt; (b) adding hydrogen peroxide and a ferrous salt to the solution prepared in step (a) to oxidatively degrade the high molecular weight polyuronic acid; and (c) isolating a polyuronic acid having an average degree of polymerization less than 20 obtained in step (b).
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: June 7, 2005
    Assignee: Seiko Epson Corporation
    Inventor: William Marritt
  • Patent number: 6878729
    Abstract: Compounds having a structure according to Formula (I): are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: April 12, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Ji-In Kim Almstead, Nicholas John Izzo, David Robert Jones, Richard Masaru Kawamoto
  • Patent number: 6872711
    Abstract: The present invention relates to novel ?-substituted-?-aminoethylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: March 29, 2005
    Assignee: Ilex Oncology Research S.A.
    Inventors: Hieu Trung Phan, Lan Mong Nguyen, Vinh Van Diep, Raymond Azoulay, Eric Joseph Niesor, Craig Leigh Bentzen, Robert John Ife
  • Patent number: 6867307
    Abstract: Intermediate compounds which can be used in the preparation of phytone and Vitamin E, a process for the preparation thereof, and a process for the preparation of phytone and Vitamin E from these intermediate compounds.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: March 15, 2005
    Assignee: Adisseo France S.A.S.
    Inventors: Jean-Erick Ancel, Pierre Meilland
  • Patent number: 6867309
    Abstract: A red-emitting organic electroluminescent compound, the structure of the compound as follows: wherein n is an integer of 1˜6; Ar represents aryl or heteroaryl; R1 and R2 individually represent alkyl of from 1 to 20 carbon atoms, aryl, carbocyclic and other heterocyclic systems; R3 and R4 individually represent hydrogen, alkyl of from 1 to 10 atoms, branched or unbranched 5 or 6 member substituent ring connecting respectively with R1 and R2, or alkyl methyl silane group; R5 represents alkyl of from 1 to 20 atoms, aryl, or heteroaryl; and R6 represents alkyl of from 1 to 10 atoms, and a 5 or 6-member carbocyclic ring connecting with R5.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: March 15, 2005
    Assignees: Chi Mei Optoelectronics Corporation, Kyocera Corporation
    Inventors: Ruey-Min Chen, Jun-Wen Chung, Chun-Che Hsu
  • Patent number: 6864219
    Abstract: The invention relates to novel substituted aryl ketones of the general formula (I) wherein all variables are as defined in the specification, and to processes for their preparation, to intermediates and to the use of these compounds as herbicides.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: March 8, 2005
    Assignees: Bayer Aktiengesellschaft, Nihon Bayer Agrochem, K.K.
    Inventors: Otto Schallner, Stefan Lehr, Hans-Georg Schwarz, Klaus-Helmut Müller, Dorothee Hoischen, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Akihiko Yanagi, Shinichi Narabu, Toshio Goto
  • Patent number: 6858623
    Abstract: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: February 22, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Younes Bekkali, Eugene R. Hickey, Weimin Liu, Usha R. Patel, Denice M. Spero, Sanxing Sun, David S. Thomson, Yancey D. Ward, Erick R. R. Young
  • Patent number: 6855828
    Abstract: Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: February 15, 2005
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Cameron J. Koch, Alexander V. Kachur, Sydney M. Evans, Chyng-Yann Shiue, Ian R. Baird, Kirsten A. Skov, William R. Dolbier, Jr., An-Rong Li, Brian R. James
  • Patent number: RE39723
    Abstract: Seco-baccatin III derivatives of formula: wherein R, R1-R4, R1 R?, R11 R?, and R111 R?? are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; and methods for treating cancer, arthritis, and inhibiting angiogenesis in an animal comprising administrating to a patient in need thereof a therapeutically effective amount of a seco-baccatin III derivative are disclosed.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: July 10, 2007
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Alessandro Pontiroli