Abstract: The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers
thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
Type:
Grant
Filed:
December 15, 1997
Date of Patent:
April 3, 2001
Assignee:
Aventis Pharmaceuticals Inc.
Inventors:
John M. Kane, George D. Maynard, Timothy P. Burkholder, Larry D. Bratton, Christopher R. Dalton, Braulio Santiago, Elizabeth M. Kudlacz