Patents Examined by Charanjit Aulakh
  • Patent number: 10844039
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: November 24, 2020
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • Patent number: 10844057
    Abstract: The invention is directed to a process for preparing compounds which are useful as intermediates for the preparation of medicinal agents having inhibitory activity for JAK.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: November 24, 2020
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Pierre-Jean Colson, Gene Timothy Fass
  • Patent number: 10844033
    Abstract: The present invention relates to methods of forming delta-lactone compounds by reaction of a diene with carbon dioxide in the presence of Pd and a phosphine ligand.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: November 24, 2020
    Assignees: Qatar Found. For Ed., Science and Community Development, Sultan Qaboos University, Leibniz-Institut Fur Katalyse e.V. an der Unversitat Rostock
    Inventors: Sarim Dastgir, Badria Al-Shihi, Mohammad Sharif, Matthias Beller, Ralf Jackstell
  • Patent number: 10836755
    Abstract: Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: November 17, 2020
    Assignee: CYTOKINETICS, INC.
    Inventors: Chihyuan Chuang, Bradley P. Morgan, Mark Vanderwal, Wenyue Wang, Luke W. Ashcraft
  • Patent number: 10836761
    Abstract: The present invention includes certain conchinine-derived phase-transfer catalysts of formula (I), compositions comprising the same, and methods of promoting asymmetric addition reactions using the same.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: November 17, 2020
    Assignee: Brandeis University
    Inventors: Yongwei Wu, Li Deng
  • Patent number: 10836785
    Abstract: Tetradentate and octahedral metal complexes suitable for use as phosphorescent or delayed fluorescent and phosphorescent emitters in display and lighting applications.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: November 17, 2020
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Jian Li, Guijie Li
  • Patent number: 10829497
    Abstract: Disclosed are a crystal form II of a thienopyridine derivative bisulfate and a preparation method therefor and the use thereof. The X-ray powder diffraction pattern of the crystal form II represented by the 2? diffraction angle exhibits characteristic diffraction peaks at 12.86°, 13.58°, 15.58°, 17.64°, 18.42°, 21.56°, 22.90°, 23.70° and 24.64°. The crystal form can be used as an active ingredient for preparing a pharmaceutical composition for preventing and treating diseases caused by thrombi. Compared with the original crystal form, the crystal form II of the invention has a better stability, with denser bulk solid particles, and is less susceptible to static electricity, and has better fluidity and compressibility, and when used as an active ingredient for preparing a pharmaceutical composition, the pharmaceutical preparation prepared with the crystal form II has a stronger stability.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: November 10, 2020
    Assignee: ZHONGRONG KAITE (BEIJING) BIOTECHNOLOGY CO., LTD.
    Inventors: Jingkai Gu, Xueyu Xu, Hao Wang, Xue Zhao
  • Patent number: 10822329
    Abstract: The present invention relates to providing a novel glyceric acid ester which can be produced in a high yield and is expected to be applied as a synthetic intermediate, and a method of producing the same. In addition, the present invention relates to providing a novel glyceric acid ester which exhibits a high recovery in a water-washing step after the reaction and a small work load at the time of production, and is expected to be applied as a synthetic intermediate, and a method of producing the same.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: November 3, 2020
    Assignee: KAO CORPORATION
    Inventor: Takashi Aoki
  • Patent number: 10813942
    Abstract: Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: October 27, 2020
    Assignee: Pfizer Inc.
    Inventors: Spiros Liras, Vincent Mascitti, Benjamin Thuma
  • Patent number: 10815210
    Abstract: The present invention is directed to benzocyclobutane derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity. More particularly, the compounds of the present invention are useful in the treatment of for example, Type II diabetes mellitus, Syndrome X, and complications and symptoms associated with said disorders.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 27, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Micheal Gaul, Gee-Hong Kuo, Guozhang Xu, Yin Liang
  • Patent number: 10815235
    Abstract: The present invention provides novel neuromodulatory compounds and compositions thereof. The invention also relates to methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; as well as intermediates for the preparation compounds.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: October 27, 2020
    Assignee: Xoc Pharmaceuticals
    Inventors: Thomas Armer, Scott Borland, Miguel Guzman
  • Patent number: 10807965
    Abstract: The present invention relates to a process for the preparation of apalutamide. In particular, the present invention relates to a process for the preparation of apalutamide and its intermediates. The present invention also relates to pharmaceutical compositions comprising apalutamide.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: October 20, 2020
    Assignee: CADILA HEALTHCARE LIMITED
    Inventors: Kumar Kamlesh Singh, Nikhil Amar Singh, Ganpat Dan Shimbhu Charan, Nimeshkumar Mukeshkumar Shah
  • Patent number: 10807967
    Abstract: Disclosed herein is a method of preparing N-acyl anthranilamide (I), including: reacting a substituted anthranilic acid (II) with pyrazolecarboxylic acid (III) under the action of a phosphorus reagent and a base to obtain an intermediate benzoxazinone (IV); and subjecting the intermediate benzoxazinone (IV) and a protonic acid salt of methylamine to a ring-opening reaction to obtain N-acyl anthranilamide (I), as shown in the following reaction scheme: where X is hydrogen, chloro or cyano group; and HY is hydrohalic acid, sulfuric acid, phosphoric acid or a carboxylic acid. The method has the advantages of simple operation, mild reaction conditions, less waste and high overall yield, and thus is suitable for industrial production.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: October 20, 2020
    Assignee: MAX (RUDONG) CHEMICALS CO., LTD.
    Inventors: Baochuan Guan, Tianhao Zhang, Qiuju Sheng, Bangchi Chen
  • Patent number: 10804476
    Abstract: Platinum and palladium complexes are disclosed that can be useful as narrow band phosphorescent emitters. Also disclosed are methods for preparing and using the platinum and palladium complexes.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: October 13, 2020
    Assignee: ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Jian Li, Eric Turner
  • Patent number: 10799484
    Abstract: The present invention describes the use of a 5HT3-antagonist, in combination with a 6-propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine, to reduce adverse effects and to facilitate the neuroprotective treatment of a patient suffering from a synucleinopathic disorder to enable a therapeutically effective 6-propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine daily dose without the dose-limiting adverse effects caused by pramipexole when administered alone.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: October 13, 2020
    Assignee: CHASE THERAPEUTICS CORPORATION
    Inventors: Thomas N. Chase, Kathleen E. Clarence-Smith
  • Patent number: 10799613
    Abstract: The present invention relates to methods of metathesizing olefins using catalysts previously considered to be practically inactive. The present invention further relates to novel photosensitive compositions, their use as photoresists, and methods related to patterning polymer layers on substrates. Further, modifications to the compositions and method provide for an unprecedented functionalization of the compositions, useful for example in the preparation of sensors, drug delivery systems, and tissue scaffolds. The novel compositions and associated methods also provide for the opportunity to prepare 3-dimensional objects which provide new access to critically dimensioned devices, including for example photonic devices.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: October 13, 2020
    Assignee: California Institute of Technology
    Inventors: Raymond Weitekamp, Robert H. Grubbs, Harry A. Atwater, James Fakonas
  • Patent number: 10790457
    Abstract: Tridentate platinum, palladium, and gold complexes of Formulas A-I and A-II and tridentate iridium and rhodium compounds of Formulas B-I, B-II, and B-III suitable for delayed fluorescent and phosphorescent or phosphorescent emitters in display and lighting applications.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: September 29, 2020
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Jian Li, Guijie Li
  • Patent number: 10774031
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: September 15, 2020
    Assignee: XW LABORATORIES INC.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Xuan Zhang
  • Patent number: 10774101
    Abstract: Optionally substituted BODIPY-Iridium complexes, such as those depicted Formula 4, may be useful in filters for display devices.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: September 15, 2020
    Assignee: NITTO DENKO CORPORATION
    Inventor: Tissa Sajoto
  • Patent number: 10765116
    Abstract: The invention relates to compounds of the formula (Ia) or (Ib), in which Aa, Ab, Ac, Ad, R1, R10 R11, R12, R13, R14, R15, R16, R17, Q, R4, R5, R6 and have the meanings indicated in the claims, and to agrochemical formulations containing the compounds according to formula (Ia) or (Ib) for use as acaricides and/or insecticides for combating animal pests, primarily arthropods and in particular insects and arachnids. 2-[3-(alkylsulfonyl)-2H-indazol-2-yl]-3H-imidazo[4,5-b]pyridine derivatives and similar compounds are particularly preferable.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: September 8, 2020
    Assignees: BAYER CROPSCIENCE AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFT
    Inventors: Nina Kausch-Busies, Rüdiger Fischer, Laura Hoffmeister, David Wilcke, Dominik Hager, Matthieu Willot, Marc Mosrin, Kerstin Ilg, Ulrich Görgens, Andreas Turberg