Patents Examined by Charanjit S. Aulakh
  • Patent number: 8778956
    Abstract: The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: July 15, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Kathleen Battista, Gilles Bignan, Peter J. Connolly, Allen B. Reitz, Tina Morgan Ross, Malcolm Scott, Steven A. Middleton, Michael Orsini
  • Patent number: 8173698
    Abstract: The present invention provides fluorogenic probes and corresponding fluorescent compounds, methods of using the probes, compounds and kits that include the probes.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 8, 2012
    Assignee: Life Technologies Corporation
    Inventors: Iain Johnson, Jixiang Liu, Brian Patch, Wai-Yee Leung
  • Patent number: 8158801
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: April 17, 2012
    Assignee: Life Technologies Corporation
    Inventors: Gayle Buller, Jixiang Liu, Stephen T. Yue, Jolene Bradford
  • Patent number: 8119803
    Abstract: A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CH3 or a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH3)2OH, (CH3)(C(CH3)3)OH or COCH3; Z is C2-C10 alkyl or C2-C10 arylalkyl; and is a single bond or a double bond, is disclosed. The process includes reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: February 21, 2012
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Melville Mitchell, Neil Kenneth Thomson, George Scott Wilson, Neil John Goodwin, Maureen Joan Young
  • Patent number: 8071769
    Abstract: A halogenated aromatic monomer-metal complex useful for preparing a polymer for electronic devices such as a light-emitting diode (LED) device is described. The aromatic monomer-metal complex is designed to include a linking group that disrupts conjugation, thereby advantageously reducing or preventing electron delocalization between the aromatic monomer fragment and the metal complex fragment. Disruption of conjugation is often desirable to preserve the phosphorescent emission properties of the metal complex in a polymer formed from the aromatic monomer-metal complex. The resultant conjugated electroluminescent polymer has precisely controlled metal complexation and electronic properties that are substantially or completely independent of those of the polymer backbone.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: December 6, 2011
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Wanglin Yu, James J. O'Brien
  • Patent number: 8048337
    Abstract: Disclosed are a composition comprising a mixture of at least one iridium organometallic compound and an electrically conductive polymer, an organic active layer comprising the same, an organic memory device comprising the organic active layer and methods for fabricating the same. The organic memory device may include a first electrode, a second electrode and the organic active layer between the first and second electrodes. The organic memory device possesses the advantages of rapid switching time, decreased operating voltage, decreased fabrication costs, increased reliability and improved non-volatility.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: November 1, 2011
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kwang Hee Lee, Yi Yeol Lyu, Sang Kyun Lee
  • Patent number: 7994187
    Abstract: HIV inhibitory compounds of formula: salts, hydrates, solvates, N-oxides, or stereoisomers thereof, wherein A forms pyridine, pyrimidine, pyrazine, pyridazine, triazine, imidazole, pyrazole, triazole, tetrazole, oxazole, isoxazole, oxadiazole, thiazole, isothiazole, and thiadiazole; R1 is halo, cyano, nitro, C1-6alkyl, polyhaloC1-6alkyl, —C1-6alkyl-OR4, —C(?O)—R5, —C(?O)—OR4, —C(?O)—NR6R7, —OR4, —O—C(?O)—C1-6alkyl, —O—C1-6alkyl-OR4, —O—C1-6alkyl-NR6R7, —O—C1-6alkyl-O—C(?O)—C1-6alkyl, —O—C1-6alkyl-C(?O)—OR4, —O—C1-6alkyl-C(?O)—NR6R7, —NR6R7, —NR8—C(?O)—R5, —NR8—C(?O)—OR4, —NR8—C(?O)—NR6R7, —NR8—C(?O)—C1-6alkyl-C(?O)—OR4, —NR8—C1-6alkyl-OR4, —NR8—C1-6alkyl-NR6R7, —NR8—C1-6alkyl-imidazolyl, —NR8—SO2R9, —N?CH—NR6R7, —NH—C(?NH)—NH2, —SO2NR6R7, and —O—PO(OR8)2; D forms pyridine, pyrimidine, pyrazine, pyridazine, pyrrole, imidazole, pyrazole, furane, oxazole, isoxazole, thiophene, thiazole, and isothiazole; R2 is C1-6alkyl, polyhaloC1-6alkyl, halo, cyano, —COOR4, —OR4, and —NR6R7; R3 is phenyl, pyridyl, pyrimid
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: August 9, 2011
    Assignee: Tibotec Pharmaceuticals Ltd.
    Inventors: Bart Rudolf Romanie Kesteleyn, Wim Bert Griet Schepens
  • Patent number: 7989644
    Abstract: Disclosed are electroluminescent devices that comprise organic layers that contain dibenzofuran compounds. The compounds are suitable components of, for example, blue-emitting, durable, organo-electroluminescent layers. The electroluminescent devices may be employed for full color display panels in, for example, mobile phones, televisions and personal computer screens.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: August 2, 2011
    Assignee: BASF SE
    Inventors: Junichi Tanabe, Hidetaka Oka, Hiroshi Yamamoto
  • Patent number: 7989478
    Abstract: The present invention relates to a cinnamoyl compound represented by the formula (I):
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: August 2, 2011
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yoshitaka Tomigahara, Kiyoshi Higashi, Junya Takahashi, Chizuko Takahashi
  • Patent number: 7985602
    Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: July 26, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Ronald J. Graham, Ruiming Zou, Krishna G. Upadhya, Scott C. Benson
  • Patent number: 7977483
    Abstract: A process of making topotecan or a pharmaceutically acceptable salt thereof comprising reacting an iminium salt with 10-hydroxy-camptothecin.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: July 12, 2011
    Assignee: Scinopharm Taiwan, Ltd.
    Inventors: Tsung-Cheng Hu, Piin-Jye Harn
  • Patent number: 7968714
    Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: June 28, 2011
    Assignee: Regents of the University of California
    Inventors: Bakthan Singaram, Ritchie A. Wessling
  • Patent number: 7964590
    Abstract: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: June 21, 2011
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Andre Lescarbeau, Martin Tremblay
  • Patent number: 7964361
    Abstract: Disclosed are analogues of trimethine cyanine dyes, which are useful for importing fluorescent properties to target materials by covalent and non-covalent association.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: June 21, 2011
    Assignee: Carnegie Mellon University
    Inventors: Alan S. Waggoner, Ratnakar B. Mujumdar
  • Patent number: 7960547
    Abstract: The present invention discloses a transition metal complex having carbene ligands. The disclosed transition metal complex has a structure of a center transition metal surrounded by two identical carbene ligands and one double-chilating ligand which is a nitrogen-contain heteroaryl group compound with pyridyl group.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: June 14, 2011
    Inventors: Chien-Hong Cheng, Cheng-Han Hsieh, Kun-Yi Lu
  • Patent number: 7960403
    Abstract: Compounds according to formula (I): wherein A, R1, R2 and R3 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: June 14, 2011
    Assignee: Virochem Pharma Inc.
    Inventors: Laval Chan Chun Kong, Christophe Moinet, Marc Courchesne, Louis Vaillancourt, Charles Blais, Monica Bubenik
  • Patent number: 7960401
    Abstract: The use of a compound of formula I Y is a single bond, C?O, C?S or S(O)m m where m is 0, 1 or 2; the ring represented by T is a 5 or 6 membered heteroaromatic and R1, R2, R3, R8 and Ra are specified organic groups and p is 0, 1, 2, 3, 4, 5 or 6; q is 0, 1, 2, 3, 4, 5 or 6; p+q is 1, 2, 3, 4, 5 or 6; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs; novel compounds are also provided.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: June 14, 2011
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Jérôme Cassayre, Louis-Pierre Molleyres, Peter Maienfisch, Fredrik Cederbaum
  • Patent number: 7960412
    Abstract: The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; ??(I-1) formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R? represents 1 to 4 independent hydrogen atoms and the like; and R? represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: June 14, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Shinichi Hamaoka, Noritaka Kitazawa, Kazumasa Nara, Atsushi Sasaki, Atsushi Kamada, Tadashi Okabe
  • Patent number: 7951817
    Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: May 31, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, Southern Research Institute, University of New England College of Osteopathic Medicine, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca
  • Patent number: 7951815
    Abstract: Novel 1,4,8-triazaspiro[4,5]decan-2-one compounds corresponding to formula I processes for the preparation thereof, related methods of treatment and pharmaceutical formulations containing such compounds.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: May 31, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Corinna Sundermann, Bernd Sundermann, Stefan Ober-Boersch, Werner Englberger, Hagen-Heinrich Hennies