Patents Examined by Charesse Evans
  • Patent number: 6932980
    Abstract: The present invention is to a safe, biodegradable trace metal binding system that effectively delivers chromium, cobalt, copper, iron, manganese, molybdenum, selenium and zinc to animals. The method of preparing an animal foodstuff composition involves the steps of: providing transgenic algal cells comprising a nucleotide sequence, the nucleotide sequence being capable of expressing a non-native metal-binding protein in the transgenic algal cells; binding the metal-binding protein with at least one metal so as to produce a metal-bound adduct of the metal-binding protein; and admixing the metal-bound adduct with animal foodstuff. The invention is also to a animal foodstuff composition comprising animal foodstuff and transgenic algal cells expressing a non-native metal-binding protein in the transgenic algal cells, such that the transgenic algal cells contain the metal-binding protein and the metal-binding protein being bound to a metal.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: August 23, 2005
    Inventors: Richard Sayre, Richard Wagner
  • Patent number: 6899891
    Abstract: Nutritional compositions comprising at least one of aloe vera, hydrolyzed collagen, garcinia cambogia, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are disclosed. Nutritional compositions comprising aloe vera, hydrolyzed collagen, garcinia cambogia tea, fenugreek tea, coleus forskohli tea, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are also disclosed. Methods for preparing and using these compositions are additionally provided.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: May 31, 2005
    Inventor: Harry J. Siskind
  • Patent number: 6858231
    Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: February 22, 2005
    Assignee: J. Rettenmaier & Soehne GmbH + Co. KG
    Inventors: Bob E. Sherwood, John H. Staniforth, Edward A. Hunter
  • Patent number: 6844009
    Abstract: The invention concerns novel media in the form of complex dispersions, method for preparing same and their uses. Said media consist of a first medium in the form of droplets wherein is dispersed a phase containing organized double layers of surfactants, preferably in the form of multilamellar vesicles, said droplets being in emulsion in a second medium called continuous phase non-miscible with the first medium. Said media can be used as base for cosmetic compositions. They can contain active principles, in particular for controlling their release and/or protecting and/or controlling their pH. They can also be used to make polymer microspheres containing an active principle. They are also useful as antigen vector.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: January 18, 2005
    Assignee: Capsulis
    Inventors: Corinne Degert, Philippe Poulin, Stéphane Ugazio, René Laversanne, Didier Roux
  • Patent number: 6793933
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to enhance the immune system (e.g., increase the activity of T and B lymphocytes and natural killer cells) in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: September 21, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Ling Yuk Cheung
  • Patent number: 6759055
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to improve kidney functions (e.g., restoring urine secretion and/or lowering blood urea nitrogen, serum proteinuria, and/or serum creatinine levels) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making such compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: July 6, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Ling Yuk Cheung
  • Patent number: 6756050
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to improve the memory of a mammal. Also included are methods of making such compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: June 29, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Larry Ling Yuk Cheung
  • Patent number: 6753008
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to normalize the serum level of GPT, AP and/or LDH-5 in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: June 22, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Ling Yuk Cheung
  • Patent number: 6743445
    Abstract: A method of coating an active material is provided. The method comprises contacting an active material with a film-forming composition comprising an aqueous dispersion of an amylose-alcohol complex, an insoluble film-forming polymer and a plasticiser at a temperature of less than 60° C. The method finds particular application in the preparation of dosage forms comprising active materials that are unstable at temperatures in excess of 60° C. The compositions prepared in accordance with the method can be used to deliver an active material to the colon.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: June 1, 2004
    Assignee: BTG International Limited
    Inventors: John Michael Newton, Chuei Wuei Leong
  • Patent number: 6737076
    Abstract: A hypoallergenic composition for the induction of protein tolerance in at risk individuals of protein allergy. The composition contains (i) a “non allergenic” protein extensively hydrolyzed basis and/or of (ii) a free amino acid basis. The composition contains, as an active ingredient, at least one tolerogenic peptide of the allergenic protein.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: May 18, 2004
    Assignee: Nestec S.A.
    Inventors: Rodolphe Fritsche, Sophie Pecquet, Lionel Bovetto, Francoise Maynard
  • Patent number: 6733788
    Abstract: A system for delivering solute to a target location within a mammalian body, the system including a medical device, a thermosensitive cellulose gel structure over the medical device, and a biologically active solute within said gel structure. The gel structure deswells and expels the biologically active solute with an increase in gel temperature. The invention includes a method of delivering solute to a target location, where the method includes the steps of providing a thermosensitive cellulose gel structure, wherein the gel structure is loaded with a solute; positioning the loaded gel structure to the target location; and increasing the temperature of the loaded gel structure.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: May 11, 2004
    Assignee: SciMed Life Systems, Inc.
    Inventors: James F. McBride, Stevin H. Gehrke, John P. Fisher
  • Patent number: 6726919
    Abstract: A sterile, injectable homogenized dispersion of micromatrices or microdroplets having a mean diameter from about 50 nm to about 1000 nm comprising about 1% to about 7.5% of propofol, about 1% to about 8% of a propofol-soluble diluent, and about 0.67% to about 5% of a surface stabilizing amphiphilic agent suspended in an aqueous medium containing a synergetic quantity of antimicrobial agent and a tonicity modifying amount of a pharmaceutically acceptable water-soluble hydroxyl-group-containing excipient, wherein the ratio of propofol to diluent is in the range of about 0.25 to about 7.5 while the ratio of propofol to amphiphilic agent is in the range from about 0.4 to about 1.5, and wherein the viscosity of the dispersion is in the range of 1.1 to 8 cps, processes for the formation of the dispersion, and methods of use are disclosed.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: April 27, 2004
    Assignee: RTP Pharma, Inc.
    Inventors: Gary W. Pace, Michael G. Vachon, Awadesh K. Mishra, Robert A. Snow
  • Patent number: 6726918
    Abstract: Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodible polymer, wherein the implant delivers the agent to the vitreous in an amount sufficient to reach a concentration equivalent to at least about 0.05 &mgr;g/ml dexamethasone within about 48 hours and maintains a concentration equivalent to at least about 0.03 &mgr;g/ml dexamethasone for at least about three weeks.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: April 27, 2004
    Assignee: Oculex Pharmaceuticals, Inc.
    Inventors: Vernon G. Wong, Mae W. L. Hu
  • Patent number: 6719993
    Abstract: Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: April 13, 2004
    Assignee: Skeletal Kinetics, LLC
    Inventor: Brent R. Constantz
  • Patent number: 6716444
    Abstract: A drug eluting medical device is disclosed. The device includes a barrier layer for reducing the rate of release of a drug.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: April 6, 2004
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Daniel Castro, Stephen D. Pacetti
  • Patent number: 6703045
    Abstract: A composition useful for reducing serum glucose levels by an oral controlled release system and a method for treating diabetes in a human being by controlling the blood glucose level (BGL) and reducing the complications associated with diabetic hyperglycemia and also the long term management of Non-Insulin Dependent Diabetes Mellitus (NIDDM) by avoiding the problems associated with the tight control of BGL, i.e., hypoglycemia tolerance and seizures. The composition is directed to a solid, hydrophilic matrix controlled release oral dosage form where the dosage form contains a therapeutically effective amount of antidiabetic drug in the matrix ensuring complete bioavailability of the drug from the matrix of the tablet.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: March 9, 2004
    Assignee: Council of Scientific & Industrial Research
    Inventors: Sanju Dhawan, Anil Kumar Singla
  • Patent number: 6689346
    Abstract: A reshapable hair styling composition comprising at least one acrylic copolymer comprising: (a) units derived from at least one monomer chosen from (meth)acrylate esters of C4 to C18 straight and branched chain alkyl alcohols, (b) units derived from at least one monomer chosen from (meth)acrylate esters of saturated and unsaturated cyclic alcohols containing 6 to 20 carbon atoms, (c) optionally units derived from at least one monomer chosen from hydrophilic monomers, and (d) optionally units derived from at least one monomer other than (a), (b), and (c) monomers, wherein said composition provides a reshapable effect.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: February 10, 2004
    Assignee: L'Oreal
    Inventors: Isabelle Rollat, Henri Samain
  • Patent number: 6685926
    Abstract: A method of conditioning and oxidatively dyeing human hair includes applying an oxidative hair dyeing composition to the human hair in order to dye the human hair and, simultaneously or subsequently to the applying of the oxidative hair dyeing composition, applying a particular hair conditioning composition to the hair. This hair conditioning composition has a pH value of from 3.4 to 3.9, which corresponds to an isoelectric point of the human hair, and contains from 0.001 to 2.5% by weight of a cationic polymer, an optional pH buffer and preferably additional conditioning ingredients, such as a cationic surfactant and/or a fatty alcohol.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: February 3, 2004
    Assignee: Wella Aktiengesellschaft
    Inventors: Ursula Hehner, Herbert Deutz, Petra Braun, Ernst Flemming
  • Patent number: 6667050
    Abstract: The present invention relates to a chewable, palatable oral contraceptive tablet, comprising an oral contraceptive agent, a chewable carrier suitable for human consumption, and not comprising a ferrocene compound, as well as use of these tablets in a method of human female oral contraception, and in a method of enhancing compliance with a human female oral contraceptive regimen.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: December 23, 2003
    Assignee: Galen (Chemicals) Limited
    Inventors: Roger M. Boissonneault, Tina M. deVries
  • Patent number: RE38522
    Abstract: The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone powder. The bone powder has a particle size ranging from about 100 to about 850 microns and is mixed in a high molecular weight hydrogel carrier, the hydrogel component of the carrier ranging from about 0.3 to 3.0% of the composition and having a molecular weight of about at least 10,000 Daltons. The composition contains about 25% to about 40% bone powder and can be additionally provided with BMP's and a sodium phosphate buffer.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: May 25, 2004
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Arthur A. Gertzman, Moon Hae Sunwoo