Abstract: The present invention relates to a cartridge for sandwich ELISA pre-loaded with antigen customized detection reagent to more efficiently perform the sandwich ELISA and a sandwich ELISA device using the cartridge. A cartridge for sandwich ELISA according to the present invention is arranged in rows and columns, and includes a body in which wells accommodating reagents are formed, a pin-assy including pins that have a capture antibody coated on one ends thereof, and a provider that moves the pin-assy to provide the well with the pin to allow the reagents and the capture antibody to be into contact and react with each other.

Abstract: Disclosed are a biosensor structure for sample measurement and a sample measuring method using same.

Abstract: Provided is an automatic analyzer capable of simplifying control of a holding unit that holds a plurality of containers having access to an aspiration nozzle whose position is fixed and that rotates and moves up and down. The automatic analyzer includes an aspiration nozzle whose position is fixed and that aspirates reaction liquid or reagent, and a holding unit that holds a plurality of containers accommodating the reaction liquid or the reagent, and that rotates and moves t up and down. The holding unit holds at least three of the containers, and an angle between adjacent containers is an integer multiple of a predetermined angle. The angle between adjacent containers is an angle between adjacent containers in a circumferential direction and an angle around a rotation center of the holding unit.

Abstract: A device and method for separating serum or plasma from blood cells in a whole blood specimen. The present invention uses a cap with a reservoir, such that blood cells are packed into the cap when the specimen container is centrifuged. When the cap is removed, the blood cells are also removed, and the serum or plasma is left in the specimen tube where it can be readily extracted by a pipette which is able to reach all the way to the bottom of the specimen tube minimizing the dead volume.

Abstract: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (~>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

Abstract: An automatic analyzer performs a dispensing operation with high throughput while reducing a risk of carry-over of a reagent that includes first and second dispensing operations. The second dispensing operation includes a first procedure of aspirating a sample accommodated by a dispensing nozzle, a second procedure of discharging the aspirated sample to a first reaction container, a third procedure in which a cleaning tank cleans an inner side and an outer side of the dispensing nozzle after the second procedure, a fourth procedure of aspirating the reagent accommodated in a reagent container after the third procedure, a fifth procedure B5 in which the cleaning tank cleans the outer side of the dispensing nozzle after the fourth procedure, a sixth procedure of aspirating the sample accommodated in the first reaction container after the fifth procedure, and a seventh procedure of discharging the reagent and the sample to a second reaction container.

Abstract: The present invention relates to a blood separation tube used in centrifugation devices and, more specifically, to a blood separation tube comprising a cell activation part configured to generate physical stress through collision with blood being centrifuged, so that blood cells in the blood, such as platelets, white blood cells, and lymphocytes, can be activated. To this end, the present invention comprises: a tube body having a chamber for accommodating blood; and a cell activation part which protrudes from the inner surface or inside of the chamber so as to activate blood cells through physical collision with blood being centrifuged.

Abstract: Systems for nucleic acid amplification testing are provided. The systems comprise a consumable amplification module and a reader module for receiving the amplification module. The amplification module comprises: a reactor vessel for containing a test sample; a heater comprising a heater element in thermal contact with the reactor vessel and controllable to add heat to the reactor vessel so as to heat the test sample; a temperature sensor for determining the temperature of at least one of the heater element and the test sample; and a heat sink or a heat spreader in thermal contact with the heater. The reader module comprises: a heater controller for selectively controlling the heater element between an on condition and an off condition in response to the determined temperature of the heater element and/or test sample; and an electrical heater interface for connecting the heater controller and the heater.

Abstract: A filtration module for filtering a process medium in a bioprocess including a process flow path for a process medium, a filter membrane coupled to the process flow path, and a sampling membrane coupled both to the process flow path and to a sampling flow path for extracting a sample from the process medium. The sampling flow path guides the extracted sample to a sampling outlet of the filtration module or to an analyzer integrated into the filtration module. A filtration assembly including the filtration module and an analyzer coupled to the sampling outlet of the filtration module. A method of sampling during a bioprocess including providing such a filtration module, urging a process medium through the process flow path, filtering the process medium by using the filter membrane, extracting a sample from the process medium by using the sampling membrane, and guiding the extracted sample to a sampling outlet.

Abstract: A cell analysis device includes a determination target identifier extraction portion configured to extract a determination target identifier that is information indicating an identification substance associated with a determination target cell that is a cell of a determination target from a table indicating a corresponding relationship between the cell and the identification substance for each compartment with respect to compartments flowing along a flow path including the cell and the identification substance that is a substance associated with the cell, an identifier acquisition portion configured to acquire the identifier that is the information for identifying the identification substance included in the compartments flowing along the flow path, a determination portion configured to determine a compartment including the determination target cell among the compartments flowing along the flow path on the basis of the identifier acquired by the identifier acquisition portion and the determination target iden

Abstract: A pipette includes an end section, a first section, a second section and a third section aligned along a central axis of the pipette tip. The end section comprises an orifice for aspirating and dispensing a fluid. A first kink is formed in an inner surface of the pipette tip between the first section and the second section, such that an angle between the inner surface of the first section and the central axis is smaller than an angle between the inner surface of the second section and the central axis. A second kink is formed in the inner surface of the pipette tip between the second section and the third section, such that the angle between the inner surface of the second section and the central axis is smaller than an angle between the inner surface of the third section and the central axis.

Abstract: Embodiments disclosed herein relate to methods and systems for performing an automated assay, and particularly to performing an assay on a plurality of samples on an automated instrument.

Abstract: A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.

Abstract: A cartridge for providing a target analyte for detection is described. One such exemplar cartridge includes a base portion including: (1) a receiving area disposed at or near a center region of the base portion; (2) multiple reaction wells disposed outside the center region or radially disposed at or near a perimeter of the base portion; and (3) multiple connecting tracks that substantially linearly extend from a region at or proximate to the receiving area to the multiple reaction wells and designed to convey a sample including the target analyte from the receiving area to the multiple reaction wells, each of which are configured to transform the sample to a detectable sample. Systems and methods of reacting and detecting the sample including the target analyte are also described.

Abstract: In an acid digestion reaction performed in a vessel, an elastic lid or septum can be mounted to the mouth of the vessel with a flanged band. In response to determining that a predetermined pressure has been reached in the vessel, a closing force being applied to the lid or septum can be reduced to initiate venting from the vessel. One or more parameters, including the closing force, can be monitored during the venting, and the closing force can be responsively adjusted to optimize the venting. The closing force can be provided by a clamping apparatus that may or may not include a hydraulic system. The clamping apparatus can be configured to increase the closing force in response to increased hydraulic pressure in the hydraulic system. The clamping apparatus can include an engager having an upwardly extending recess extending at least partially around a downwardly protruding portion of the engager.

Abstract: A gene detection substrate is provided, including: a substrate; a gene detection channel in the substrate, an opening of the gene detection channel is on one side of the substrate; the gene detection channel includes a sample injection groove, a sample outgoing groove and a flow channel groove sequentially connected and communicated with each other; the flow channel groove includes reaction holes and flow channel structures; the reaction holes are distributed at intervals, and any two adjacent reaction holes are communicated with each other through the flow channel structure; the flow channel structure includes a first, second, and third sub-grooves sequentially connected and communicated with each other; a width of each of the first and third sub-grooves in a first direction is smaller than that of the second sub-groove in the first direction; and the first direction is perpendicular to an arrangement direction of two adjacent reaction holes.

Abstract: Embodiments include systems for sequencing a biological sample. The system may include a reusable subsystem and a removable subsystem. The reusable subsystem may actuate and operate the removable subsystem to automate the sequencing. A base unit of the reusable subsystem may form a fluidic connection between an integrated reagent cartridge and an integrated sensor cartridge of the removable subsystem. The integrated reagent cartridge may be configured to hold reagents and the integrated sensor cartridge may be configured with a biosensor for sequencing the biological sample.

Abstract: A lateral flow assay device comprising a conjugate pad for receiving a quantity of fluid, and a membrane comprising a test line for determining whether the fluid comprises a target analyte. The device includes an actuator connected to a moving element comprising a shaft or a wheel. A first magnet is connected to the backing of the membrane. Second and third magnets are connected to the moving element. The actuator moves the moving element between first and second positions. In the first position, the opposite poles of the first and second magnets attract each other and maintain a gap between the membrane and the conjugate pad separate. In the second position, the similar poles of the first and third magnets repel each other and close the gap between membrane and the conjugate pad, allowing the fluid to flow from the conjugate pad into the membrane and the test line.

Abstract: A multi-channel head of a liquid handling apparatus for aspirating and dispensing a metered amount of liquid is configured to attach an array of disposable tips in a pick-up action, in which the multi-channel head is lowered relative to the disposable tips so as to insert each connector into an internal passageway of a corresponding disposable tip by an amount sufficient to bring an upper collar of the disposable tips into contact with an underside of the alignment plate which in turn deforms the elastomeric seal against the tip internal passageway so as to form a sealing contact therewith. An alignment action is thereafter performed in which the alignment plate is moved relative to connectors by an amount sufficient to close any gap between the underside of the alignment plate and the upper surface of the tip collars that arises due to e.g., relaxation of the deformed seals.

Abstract: A cost-effective and limited interaction explosive detector for dangerous, illegal, and/or illicit substances such as explosives, flammable or volatile fluids, and/or other appropriate substances is described. The explosive detector may be integrated into various containers or packages, such as cardboard boxes, paper envelopes, metal shipping containers, and/or other containers or packaging. The integrated explosive detector may provide a visual indication when a subject substance is encountered. The integrated explosive detector may include a port or vent that allows for ambient flow of fluids, such as air, between an interior of the container and the outside environment.