Abstract: Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.
Type:
Grant
Filed:
December 28, 2006
Date of Patent:
January 21, 2014
Assignee:
Alza Corporation
Inventors:
Mahmoud Ameri, Michel J. N. Cormier, Scott Sellers, Yuh-Fun Maa