Abstract: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.

Abstract: Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).

Abstract: Methods of treating solid organ injuries using compounds that enhance Wnt signalling are described.

Abstract: The invention relates to a stable immunogenic product for the induction of antibodies against one or more antigenic proteins in a subject. The invention is characterized in that it comprises proteinaceous immunogenic heterocomplexes which are formed by associations between (i) antigenic protein molecules and (ii) proteinaceous carrier molecules and in that less than 40% of the antigenic proteins (i) are linked to the proteinaceous carrier molecules (ii) by a covalent bond.

Abstract: The present invention relates to anti-human PAX 5 antibodies capable of binding to one or more epitopes located within the C-terminal regulatory domain of PAX 5. In particular the invention relates to an antibody, antigen binding fragment or recombinant protein thereof, which is capable of specific binding to an epitope located within the C-terminal fragment of human PAX 5 protein, wherein said epitope comprises from 3 to 17 amino acid residues of amino acid sequence GSPYYYSAAARGAAPPA (SEQ ID NO:2). The invention also relates to immunogenic peptide sequences for the production of the antibodies, diagnostic and therapeutic applications comprising using the antibodies and formulations comprising thereof.

Abstract: The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein. The fusion proteins, the nucleic acid, and the cell are suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications as described herein.

Abstract: A flexible steerable device comprising a plurality of interconnected segments configured to pivot relative to each other, each of the plurality of segments having a cavity disposed therein. The device also includes a flexible tube disposed within the cavities of the plurality of segments. The flexible tube includes at least one rigidizing chamber having fusible material disposed therein, wherein upon varying temperature of the fusible material, the fusible material shifts between a first state in which the flexible steerable device is flexible and a second state in which the flexible steerable device is rigidized.

Abstract: Contemplated compositions and methods are directed to prevent and/or treat various autoimmune diseases that are typically associated with glycan dysregulation, and especially autoimmune demyelinating diseases. Further especially contemplated aspects include animal models and systems for screening compounds to treat and/or prevent such diseases.

Abstract: An ozone delivery system, method, and apparatus are disclosed. Ozonated water can be used to disinfect and clean various surfaces, equipment, and animals in a dairy setting. Animals can be disinfected and protected from disease through the use of wash-pen and sprayer injections, and other footbath products. Ozone can be educted into a drop hose and a pre-dip line at periodic intervals and into a foot bath to provide refreshed ozonated water. The ozone delivery system and method sterilizes all equipment and floor surfaces without damaging diary equipment components. The system can incorporate computer-controlled options such as maintaining off gas levels, maintaining cleaning and disinfecting records, monitoring ozonated water levels, monitoring concentrations of ozone in said ozonated water, controlling entry and exit gates, controlling a drainage system, and monitoring and educting ozone in a foot bath and wash pen.

Abstract: The present invention provides a composition for controlling plant diseases comprising, as active ingredients, a compound represented by formula (1) and ethaboxam.

Abstract: This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure.

Abstract: A surgical tool system including a handpiece with a motor and a cutting accessory with a shaft that is rotated by the handpiece motor. The handpiece includes a coupling assembly with plural locking elements for holding the accessory shaft to an output drive shaft that is actuated by the handpiece motor. The locking elements are longitudinally spaced apart from each other. The accessory shaft is formed with retention features against which the handpiece locking elements engage. The shaft retention features are in columns. The retention features in adjacent retention features are longitudinally offset from each other. This allows the coarse or fine adjustment of the extent to which the accessory shaft extends forward from the handpiece coupling assembly.

Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

Abstract: A concentrated and one phase cleaning and disinfecting solution containing a sparingly soluble cyclic carboxylic acid. The solution has a pH of from about 0.05 to about 2, and comprises, consists essentially of, or consists of from about 2% w/w to about 8% w/w hydrogen peroxide; from about 5% w/w to about 20% w/w linear alkyl benzene sulfonic acid; from about 0.5% w/w to about 8% w/w of at least one sparingly soluble (i.e. a solubility in pure water at room temperature of less than 1% w/w) cyclic carboxylic acid, wherein the cyclic carboxylic acid is present in acid and salt form in a ratio of at least 9:1 (acid:salt); from about 2% w/w to about 10% w/w of at least one block copolymer surfactant (e.g. PLURONIC L62); and from about 4% w/w to about 15% w/w of at least one solvent.

Abstract: A device for the treatment of human or animal tissue by means of a movable instrument is disclosed. The device comprises means for generating a magnetic stator field, in which the tissue is located. For example, the means for generating the magnetic stator field may be a magnetic resonance tomograph (MRT). At least one conductor loop is provided on or in the instrument, and a generator is provided for generating a current that flows through the conductor loop in order to generate a magnetic useful field, which, in conjunction with the stator field, generates a resulting action for applying a useful force to the instrument.

Abstract: A working unit of a manipulator includes a hollow joint shaft, wires disposed as power transmitting members in the hollow joint shaft, and a distal-end working unit mounted on an end of the hollow joint shaft and movable by the wires. The wires are wound around respective tubular members in the distal-end working unit. The hollow joint shaft has a pair of visual checking holes defined in respective side walls thereof near the distal end thereof for allowing the wires to be visually checked therethrough. The visual checking holes are positioned to expose the tubular members therethrough.

Abstract: It is possible to inhibit inflammatory processes by administration of antibodies to chemokines. Identification of chemokines which are over-produced makes it possible to block specific chemokine activity using antibodies to the over-expressed chemokines.

Abstract: The present invention provides novel kinocidin peptides comprising a C-terminal portion of a kinocidin, wherein the C-terminal portion encompasses an ?-helical secondary structure and further displays antimicrobial activity. The kinocidin peptides of the invention are derived from and correspond to a C-terminal portion of a kinocidin that includes a ?KC core and that can be a CXC, CC, or C class chemokine. Structural, physicochemical and functional properties of this novel class of antimicrobial peptides and amino acid sequences of particular kinocidin peptides are also disclosed. The invention also provides related antimicrobial methods.

Abstract: A method for detecting an inflammatory disease in a subject is disclosed. The method comprises the steps of (a) detecting a level of expression of one or more inflammatory disease markers in a biological sample obtained from the subject; and (b) comparing the level of expression of said one or more inflammatory disease markers in the biological sample to a normal level of expression of the one or more inflammatory disease markers, wherein the one or more inflammatory disease markers comprise one or more markers selected from the group consisting of CXCL9, CXCL10, CXCL11, CXCL13, CXCR3 and CXCR5. Also disclosed are a method for monitoring the course of treatment for an inflammatory disease in a subject and a kit for detecting an inflammatory disease in a subject.

Abstract: Disclosed are oral rehydration compositions with sucrose, sodium, chloride, and citric acid or citrate. The composition further comprises an osmolarity of below 250 mOsm/L, and sodium below 75 meq/L. Further disclosed are methods of treatment using the same.