Patents Examined by Cheryl Liljestrand
  • Method to diagnose hereditary hemochromatosis
    Patent number: 5753438
    Abstract: New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: May 19, 1998
    Assignee: Mercator Genetics, Inc.
    Inventors: Dennis T. Drayna, John N. Feder, Andreas Gnirke, Bruce E. Kimmel, Winston J. Thomas, Roger K. Wolff
  • Detection of target nucleic acid molecules using synthesis-deficient thermostable DNA polymerase
    Patent number: 5691142
    Abstract: A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. In this novel detection method, the signal indicative of the presence of the target nucleic acid sequence is amplified through cleavage of detection molecule(s) which comprise hairpin structures.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 25, 1997
    Assignee: Third WaveTechnologies, Inc.
    Inventors: James E. Dahlberg, Victor I. Lyamichev, Mary Ann D. Brow