Patents Examined by Choon Koh
  • Patent number: 5108989
    Abstract: A method of predisposing a mammal to accelerated tissue repair is provided. This method comprises systemically administering to the mammal, prior to its exposure to tissue damage, an effective amount of TGF-.beta.. Preferably, the TGF-.beta. is administered no more than about 24 hours prior to exposure to tissue damage.
    Type: Grant
    Filed: April 4, 1990
    Date of Patent: April 28, 1992
    Assignee: Genentech, Inc.
    Inventors: Edward P. Amento, L. Steven Beck
  • Patent number: 5106836
    Abstract: A composition comprising arginine enriched whey protein can be used in the formulation of a variety of simulated food products to provide a substantially fat free, calorie controlled diet which delivers high levels of protein having a hypocholesterolemic amino acid profile.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: April 21, 1992
    Assignee: Clintec Nutrition Co.
    Inventors: Roger D. Clemens, James Martucci, W. Bruce Rowe, Irene Wei
  • Patent number: 5106832
    Abstract: Insulin-like growth factor I (IGF I) and pharmaceutical compositions comprising IGF I are useful in improving glomerular filtration and renal plasma flow and can be used for the treatment of patients suffering from renal diseases and for the preparation of therapeutic combinations for treatment of renal diseases.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: April 21, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Ernst R. Froesch, Hans-Peter Guler, Christoph Schmid, Jurgen Zapf
  • Patent number: 5073367
    Abstract: The present invention relates to a new method for increasing the productivity of sows.In the method according to the invention, Bacillus IP 5832 and/or its spores is/are administered orally to breeding sows.
    Type: Grant
    Filed: May 4, 1989
    Date of Patent: December 17, 1991
    Assignee: Guyomarc'h Nutrition Animale
    Inventor: Tan H. Nguyen
  • Patent number: 5066785
    Abstract: Methodology is described for the carboxyl-terminal sequencing of proteins and peptides using novel coupling reagents.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: November 19, 1991
    Assignee: City of Hope
    Inventor: Chad G. Miller
  • Patent number: 5064812
    Abstract: A complex of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglotaminyl- (L)-meso-diamino-pimelyl-(D-amide)-D-alanyl-D-alanine with bivalent metals chosen from the group comprising Cu.sup.2+, Zn.sup.2+, Co.sub.hu 2+ ; Ni.sup.2+ and Cd.sup.2+ in the molar ratio of the organic ligand: Cu.sup.2+ =2:1 and the organic ligand: Zn.sup.2+ or Co.sup.2+ or Ni.sup.2+ or Cd.sup.2+ =1:1, compositions containing it and their use in the treatment of immunological insufficiencies and disturbances in humans and animals.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: November 12, 1991
    Assignee: Sour Pliva
    Inventors: Bozidar Suskovic, Zlatko Vajtner, Radmila Naumski
  • Patent number: 5051406
    Abstract: The pharmaceutical composition of the present invention is a pharmaceutical composition of high drug content containing 1-200 parts by weight of a drug having a protein binding property and 100 parts by weight of albumin.This pharmaceutical composition is produced by stirring the drug and albumin of the above proportions at a high speed in an aqueous solvent and then removing the solvent by distillation, and has effects of alleviating the side effect of the drug used therein and also of improving the absorption, light stability, etc. of the drug.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: September 24, 1991
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventor: Toshio Satoh
  • Patent number: 5047344
    Abstract: The present invention relates to the discovery of a new bacteria of the genus Alteromonas which has been found to attract oyster larvae by the production of compounds involved in melanin synthesis. More specifically, the present invention contemplates a method for inducing the settlement and metamorphosis of Crassostrea virginica larvae by induction with certain metabolic substances produced by the present bacteria and its altered variants. Furthermore, the present invention is directed to other and derivative metabolic products which can be employed for their desired utility and application. In accordance with the present invention, it has been discovered that ammonia (NH.sub.3) initiates settlement and metamorphosis of the oyster larvae in the same manner as the natural phenomena.
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: September 10, 1991
    Assignee: Research Corporation Techniques, Inc.
    Inventors: Ronald M. Weiner, Rita R. Colwell, Dale B. Bonar, Steven L. Coon, Marianne Walsh
  • Patent number: 5037803
    Abstract: Process of preparation of an organo-silicon cosmetic compound having cosmetic and cutaneous resorption activity, derived from the addition or combination or complexing of a silanol with a substance which determines its cosmetic activity and an intracutaneous fixation substance.
    Type: Grant
    Filed: March 2, 1988
    Date of Patent: August 6, 1991
    Inventors: Jean Gueyne, Marie-Christine Seguin, Jacques Bondon
  • Patent number: 5036050
    Abstract: A composition for use in the topical treatment of skin disorders such as dermatitis or poison ivy, which comprises an effective amount of thymopentin and a suitable carrier is provided. A method for treating skin disorders and a method for making a topical composition are disclosed.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: July 30, 1991
    Assignee: Immunobiology Research Institute, Inc.
    Inventors: Tapan Audhya, Krishnamurthy Venkatasubramanian, Gideon Goldstein
  • Patent number: 5034227
    Abstract: A process for preparing products from legumes which comprises preparing an aqueous suspension containing finely ground seed from peas or beans, at a pH within the range of about 2.0 to 10.0, subjecting the suspension to one or more centrifugation operations and isolating therefrom at least one product containing essentially the protein content of the seed and another product containing essentially the starch content of the seed. A good quality fibrous by-product may also be isolated. The products are useful in the food industry.
    Type: Grant
    Filed: June 3, 1988
    Date of Patent: July 23, 1991
    Assignee: James Richardson & Sons Limited
    Inventor: Gary B. Nickel
  • Patent number: 5019382
    Abstract: Neoplastic disease, hyperallergenicity, autoimmune disorders characterized by chronic tissue degenerative inflammation and immuno-resistant viral infections are treated by the administration of interferon at a dosage of about 0.1 to about 5 IU/lb per day by contacting said interferon with oral/pharyngeal mucosa. Interferon is administered in solution or in a novel solid unitary dosage form adapted to be dissolved in saliva when placed in the mouth.
    Type: Grant
    Filed: January 17, 1990
    Date of Patent: May 28, 1991
    Assignee: The Texas A&M University System
    Inventor: Joseph M. Cummins, Jr.
  • Patent number: 5017559
    Abstract: The present invention provides an agent utilizing for immunological assays in medical fields for blocking nonspecific adsorption, a process for preparing thereof and a method of blocking nonspecific adsorption.The agent contains a combination of milk protein as an effective constituent and a buffer solution containing one or more principal constituents selected from the group of organic acids and their salts.
    Type: Grant
    Filed: February 24, 1989
    Date of Patent: May 21, 1991
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Shunichi Dosako, Hiroshi Shinmoto
  • Patent number: 5002764
    Abstract: A method of treating actinic keratoses with alpha.sub.2 interferon is disclosed.
    Type: Grant
    Filed: August 22, 1989
    Date of Patent: March 26, 1991
    Assignee: Schering Corporation
    Inventors: Edwin A. Peets, Kenneth A. Smiles, Daniel J. Tanner
  • Patent number: 4997646
    Abstract: A method for enhancing the fertility and for prolonging the lifespan of the corpus luteum in female mammals. The method comprising administering to the female mammal an effective amount of an interferon alpha together with one or more pharmaceutically acceptable excipients.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: March 5, 1991
    Assignees: University of Florida Research Foundation, Inc., Currators of the University of Missouri
    Inventors: Peter J. Hansen, Kazuhiko Imakawa, R. Michael Roberts, William W. Thatcher
  • Patent number: 4988675
    Abstract: The invention concerns a method for treating and preventing secondary effects of hyperinsulinemia by application of insulin-like growth factor I (IGF I), and pharmaceutical compositions comprising IGF I which are useful for this purpose.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: January 29, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Ernst R. Froesch, Hans-Peter Guler, Christoph Schmid, Jurgen Zapf
  • Patent number: 4983721
    Abstract: A method for extracting collagen from animal collagen-containing tissue using a solution of an organic amine salt. The collagen product has many uses such as cell growth matrices, prosthetic devices, synthetic skin, dressings for wounds, or membranes.
    Type: Grant
    Filed: November 25, 1988
    Date of Patent: January 8, 1991
    Assignee: Boston Biomedical Research Institute
    Inventor: Peter F. Davison
  • Patent number: 4980163
    Abstract: Broad range bacteriocin compositions are provided. The compositions can be dissolved or suspended in a suitable solvent or matrix and are more active towards a broader range of bacteria than are any of the component parts. The dissolved or suspended compositions constitute enhanced broad range bactericides. The compositions include lysostaphin and a lanthionine containing peptide bacteriocin; lysostaphin, a lanthionine containing peptide bacteriocin and a chelating agent; and lysostaphin, a lanthionine containing peptide, a chelating agent and a surfactant. Each component is present in the enhanced broad range bactericide in sufficient amount such that the bactericide is more effective against staphylococci than is lysostaphin alone and is more effective at treating and preventing a broad range of microbial infections. Methods of treating bacterial infections using said compositions and bactericides are provided.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: December 25, 1990
    Assignee: Public Health Research Institute of the City of New York
    Inventors: Peter Blackburn, Sara-Ann Gusik, June Polak, Stephen D. Rubino
  • Patent number: 4975277
    Abstract: A process for biologically controlling postharvest disease in pome fruits using an isolate of Pseudomonas cepacia having the identifying characteristics of NRRL B18388. The organisms are isolated from the surface of apple leaves and are useful to control a variety of fruit-rot pathogens in a variety of pome fruits. Also disclosed is a process for controlling postharvest diseases in pome fruit using the antifungal compound, pyrrolnitrin.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: December 4, 1990
    Assignee: United States of America
    Inventors: Wojciech J. Janisiewicz, James Roitman