Abstract: A method of predisposing a mammal to accelerated tissue repair is provided. This method comprises systemically administering to the mammal, prior to its exposure to tissue damage, an effective amount of TGF-.beta.. Preferably, the TGF-.beta. is administered no more than about 24 hours prior to exposure to tissue damage.
Abstract: A composition comprising arginine enriched whey protein can be used in the formulation of a variety of simulated food products to provide a substantially fat free, calorie controlled diet which delivers high levels of protein having a hypocholesterolemic amino acid profile.
Type:
Grant
Filed:
February 22, 1991
Date of Patent:
April 21, 1992
Assignee:
Clintec Nutrition Co.
Inventors:
Roger D. Clemens, James Martucci, W. Bruce Rowe, Irene Wei
Abstract: Insulin-like growth factor I (IGF I) and pharmaceutical compositions comprising IGF I are useful in improving glomerular filtration and renal plasma flow and can be used for the treatment of patients suffering from renal diseases and for the preparation of therapeutic combinations for treatment of renal diseases.
Type:
Grant
Filed:
December 21, 1990
Date of Patent:
April 21, 1992
Assignee:
Ciba-Geigy Corporation
Inventors:
Ernst R. Froesch, Hans-Peter Guler, Christoph Schmid, Jurgen Zapf
Abstract: The present invention relates to a new method for increasing the productivity of sows.In the method according to the invention, Bacillus IP 5832 and/or its spores is/are administered orally to breeding sows.
Abstract: A complex of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglotaminyl- (L)-meso-diamino-pimelyl-(D-amide)-D-alanyl-D-alanine with bivalent metals chosen from the group comprising Cu.sup.2+, Zn.sup.2+, Co.sub.hu 2+ ; Ni.sup.2+ and Cd.sup.2+ in the molar ratio of the organic ligand: Cu.sup.2+ =2:1 and the organic ligand: Zn.sup.2+ or Co.sup.2+ or Ni.sup.2+ or Cd.sup.2+ =1:1, compositions containing it and their use in the treatment of immunological insufficiencies and disturbances in humans and animals.
Abstract: The pharmaceutical composition of the present invention is a pharmaceutical composition of high drug content containing 1-200 parts by weight of a drug having a protein binding property and 100 parts by weight of albumin.This pharmaceutical composition is produced by stirring the drug and albumin of the above proportions at a high speed in an aqueous solvent and then removing the solvent by distillation, and has effects of alleviating the side effect of the drug used therein and also of improving the absorption, light stability, etc. of the drug.
Abstract: The present invention relates to the discovery of a new bacteria of the genus Alteromonas which has been found to attract oyster larvae by the production of compounds involved in melanin synthesis. More specifically, the present invention contemplates a method for inducing the settlement and metamorphosis of Crassostrea virginica larvae by induction with certain metabolic substances produced by the present bacteria and its altered variants. Furthermore, the present invention is directed to other and derivative metabolic products which can be employed for their desired utility and application. In accordance with the present invention, it has been discovered that ammonia (NH.sub.3) initiates settlement and metamorphosis of the oyster larvae in the same manner as the natural phenomena.
Type:
Grant
Filed:
April 25, 1988
Date of Patent:
September 10, 1991
Assignee:
Research Corporation Techniques, Inc.
Inventors:
Ronald M. Weiner, Rita R. Colwell, Dale B. Bonar, Steven L. Coon, Marianne Walsh
Abstract: Process of preparation of an organo-silicon cosmetic compound having cosmetic and cutaneous resorption activity, derived from the addition or combination or complexing of a silanol with a substance which determines its cosmetic activity and an intracutaneous fixation substance.
Type:
Grant
Filed:
March 2, 1988
Date of Patent:
August 6, 1991
Inventors:
Jean Gueyne, Marie-Christine Seguin, Jacques Bondon
Abstract: A composition for use in the topical treatment of skin disorders such as dermatitis or poison ivy, which comprises an effective amount of thymopentin and a suitable carrier is provided. A method for treating skin disorders and a method for making a topical composition are disclosed.
Abstract: A process for preparing products from legumes which comprises preparing an aqueous suspension containing finely ground seed from peas or beans, at a pH within the range of about 2.0 to 10.0, subjecting the suspension to one or more centrifugation operations and isolating therefrom at least one product containing essentially the protein content of the seed and another product containing essentially the starch content of the seed. A good quality fibrous by-product may also be isolated. The products are useful in the food industry.
Abstract: Neoplastic disease, hyperallergenicity, autoimmune disorders characterized by chronic tissue degenerative inflammation and immuno-resistant viral infections are treated by the administration of interferon at a dosage of about 0.1 to about 5 IU/lb per day by contacting said interferon with oral/pharyngeal mucosa. Interferon is administered in solution or in a novel solid unitary dosage form adapted to be dissolved in saliva when placed in the mouth.
Abstract: The present invention provides an agent utilizing for immunological assays in medical fields for blocking nonspecific adsorption, a process for preparing thereof and a method of blocking nonspecific adsorption.The agent contains a combination of milk protein as an effective constituent and a buffer solution containing one or more principal constituents selected from the group of organic acids and their salts.
Abstract: A method for enhancing the fertility and for prolonging the lifespan of the corpus luteum in female mammals. The method comprising administering to the female mammal an effective amount of an interferon alpha together with one or more pharmaceutically acceptable excipients.
Type:
Grant
Filed:
February 23, 1989
Date of Patent:
March 5, 1991
Assignees:
University of Florida Research Foundation, Inc., Currators of the University of Missouri
Inventors:
Peter J. Hansen, Kazuhiko Imakawa, R. Michael Roberts, William W. Thatcher
Abstract: The invention concerns a method for treating and preventing secondary effects of hyperinsulinemia by application of insulin-like growth factor I (IGF I), and pharmaceutical compositions comprising IGF I which are useful for this purpose.
Type:
Grant
Filed:
January 25, 1989
Date of Patent:
January 29, 1991
Assignee:
Ciba-Geigy Corporation
Inventors:
Ernst R. Froesch, Hans-Peter Guler, Christoph Schmid, Jurgen Zapf
Abstract: A method for extracting collagen from animal collagen-containing tissue using a solution of an organic amine salt. The collagen product has many uses such as cell growth matrices, prosthetic devices, synthetic skin, dressings for wounds, or membranes.
Abstract: Broad range bacteriocin compositions are provided. The compositions can be dissolved or suspended in a suitable solvent or matrix and are more active towards a broader range of bacteria than are any of the component parts. The dissolved or suspended compositions constitute enhanced broad range bactericides. The compositions include lysostaphin and a lanthionine containing peptide bacteriocin; lysostaphin, a lanthionine containing peptide bacteriocin and a chelating agent; and lysostaphin, a lanthionine containing peptide, a chelating agent and a surfactant. Each component is present in the enhanced broad range bactericide in sufficient amount such that the bactericide is more effective against staphylococci than is lysostaphin alone and is more effective at treating and preventing a broad range of microbial infections. Methods of treating bacterial infections using said compositions and bactericides are provided.
Type:
Grant
Filed:
March 1, 1989
Date of Patent:
December 25, 1990
Assignee:
Public Health Research Institute of the City of New York
Inventors:
Peter Blackburn, Sara-Ann Gusik, June Polak, Stephen D. Rubino
Abstract: A process for biologically controlling postharvest disease in pome fruits using an isolate of Pseudomonas cepacia having the identifying characteristics of NRRL B18388. The organisms are isolated from the surface of apple leaves and are useful to control a variety of fruit-rot pathogens in a variety of pome fruits. Also disclosed is a process for controlling postharvest diseases in pome fruit using the antifungal compound, pyrrolnitrin.