Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorder associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract: The present invention relates to the use of CFTR correctors in the treatment of genetic disorders affecting striated muscle selected from sarcoglycanopathies, Brody's disease (BD) and the recessive forms of Cathecolaminergic Polymorphic Ventricular Tachycardia (CPVT).
Type:
Grant
Filed:
November 29, 2013
Date of Patent:
June 5, 2018
Assignee:
UNIVERSITA' DEGLI STUDI DI PADOVA
Inventors:
Dorianna Sandona', Roberta Sacchetto, Elisa Bianchini, Pompeo Volpe, Romeo Betto, Francesco Mascarello
Abstract: The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.
Type:
Grant
Filed:
August 5, 2015
Date of Patent:
March 20, 2018
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Armin Heckel, Sara Frattini, Dieter Hamprecht, Joerg Kley
Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Type:
Grant
Filed:
November 13, 2014
Date of Patent:
January 16, 2018
Assignee:
Gilead Pharmasset LLC
Inventors:
Elizabeth M. Bacon, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, Evan S. Krygowski, John O. Link, James G. Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng-Yu Yang, Sheila Zipfel
Abstract: Methods and kits for treating oral mucositis are disclosed. The treatment comprises administering to a patient in need thereof a Reactive Oxygen Species scavenger in a pharmaceutically acceptable formulation.
Type:
Grant
Filed:
October 12, 2007
Date of Patent:
January 2, 2018
Assignee:
GALERA LABS, LLC
Inventors:
David M. Rothstein, Chris Murphy, Vivien Wong, Glenn Kazo
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Abstract: Methods and kits for treating oral mucositis are disclosed. The treatment comprises administering to a patient in need thereof a Reactive Oxygen Species scavenger in a pharmaceutically acceptable formulation.
Type:
Grant
Filed:
June 11, 2014
Date of Patent:
May 9, 2017
Assignee:
GALERA LABS, LLC
Inventors:
David M. Rothstein, Chris Murphy, Vivian Wong, Glenn Kazo
Abstract: Provided is a process for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus.
Type:
Grant
Filed:
August 10, 2012
Date of Patent:
March 21, 2017
Assignees:
Southern Research Institute, Sanford-Burnham Medical Research Institute
Inventors:
Marintha L. Heil, Nicholas D. P. Cosford, Robert Ardecky, Jiwen Zou
Abstract: The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.
Type:
Grant
Filed:
August 24, 2012
Date of Patent:
March 14, 2017
Assignee:
CYMABAY THERAPEUTICS, INC.
Inventors:
Jiangao Song, Phuongly Pham, Jingyuan Ma, Aaron Robert Novack, Imad Nashashibi, David W. G. Wone, Dong-Fang Shi, Xin Chen
Abstract: A conjugated compound of formula Q-Z—R4 wherein Q is a TLR7 and/or TLR8 agonist and Z—R4 is a TLR2 agonist, and the uses thereof in the treatment of infection, cancer or immune disorders or for use in vaccines.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
February 14, 2017
Assignee:
INVIVOGEN
Inventors:
Fabienne Vernejoul, Arnaud Debin, Daniel Drocourt, Eric Perouzel, Gerard Tiraby, Thierry Lioux
Abstract: The invention provides an anion-containing calcium phosphate compound, composition and dental patch comprising the same and their use in remineralizing teeth. The anion-containing calcium phosphate compound has the following formula: (Ca+2)x(anion?a)y(PO4?3)z wherein 2x=(a*y+3z); a is an integer of 1 to 3; and each of x, y and z is not 0.
Abstract: Disclosed are salts of 2-phenylethylamines and deprotonated inorganic acids, compositions and formulations containing the same, and methods of making and using the salts, compositions and formulations.
Type:
Grant
Filed:
June 13, 2013
Date of Patent:
December 27, 2016
Inventors:
Ronald Kramer, Alexander Nikolaidis, Bruce Kneller
Abstract: The invention relates to small molecules having biological and therapeutic activity. Particularly, the invention relates to small molecules having lipolytic and anti-adipogenic activity. Two examples of such molecules are 4-methyl-2-(octanoylamino) pentanoic acid and N-isopentyloctanamide. The invention further relates to methods of preventing or treating skin conditions such as cellulite using small molecules having lipolytic and anti-adipogenic activity.
Abstract: The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)—N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided.
Type:
Grant
Filed:
April 21, 2014
Date of Patent:
November 8, 2016
Assignee:
TAKASAGO INTERNATIONAL CORPORATION
Inventors:
Louis Lombardo, Michael E. Lankin, Kenya Ishida, Shigeru Tanaka, Hideo Ujihara, Kenji Yagi, Jennifer B. Tartaglia, Carter B. Green, Amrit S. Mankoo
Abstract: Disclosed herein are methods of treating diseases associated with increased numbers of eosinophils basophils, and/or neutrophils with R(+) pramipexole.
Type:
Grant
Filed:
August 13, 2013
Date of Patent:
October 18, 2016
Assignee:
Knopp Biosciences LLC
Inventors:
Michael E. Bozik, Gregory Hebrank, Wildon Farwell, Thomas Petzinger, Jr., Steven Dworetzky
Abstract: A conjugated compound of formula Q-Z—R4 wherein Q is a TLR7 and/or TLR8 agonist and Z—R4 is a lipid covalently linked to an amino acid or peptide coupled to a polyamine group, and a process for the manufacture of the conjugated compound, as well as a complex formed between the conjugated compound and a polyanionic molecule and a pharmaceutical composition containing the conjugated compound or complex. Also described is the use of the conjugated compound or complex in the treatment of infection, cancer or immune disorders or for use in vaccines.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
October 4, 2016
Assignee:
INVIVOGEN
Inventors:
Fabienne Vernejoul, Arnaud Debin, Daniel Drocourt, Eric Perouzel, Gerard Tiraby, Thierry Lioux
Abstract: The invention provides the use of a 4-hydroxydihydrochalcone of the formula (I) wherein R1, R2, R3 and R4 each, independently, represent H, OH or O-alkyl, with the proviso that at least one of the groups R1, R2 or R3 represents OH, a salt of such a 4-hydroxydihydrochalcone of the formula (I), a mixture containing or consisting of two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R1, R2, R3 and R4 are each defined in the way given above, a mixture containing or consisting of salts of two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R1, R2, R3 and R4 are each defined in the way given above or a mixture containing or consisting of a 4-hydroxydihydrochalcone of the formula (I) or two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R1, R2, R3 and R4 are each defined in the way given above, and a salt of a 4-hydroxydihydrochalcone of the formula (I) or two or more salts of different 4-hydroxydihydrochalcones of the formula
Type:
Grant
Filed:
March 21, 2007
Date of Patent:
September 20, 2016
Assignee:
SYMRISE AG
Inventors:
Gerhard Krammer, Jakob Ley, Thomas Riess, Martin Haug, Susanne Paetz, Günter Kindel, Ralph Schmidtmann
Abstract: Indication of use of erdosteine as antidote in a large number of intoxications, especially in heavy metals like lead or mercury, and paracetamol. Indication of use of erdosteine as prophylaxis for intoxications. Erdosteine can be administered per os or intravenous, using a solution obtained with sodium hydrogen carbonate and bidistilled water.
Type:
Grant
Filed:
August 13, 2009
Date of Patent:
August 30, 2016
Assignee:
RAFIFARM S.R.L.
Inventors:
Marco Peretto, Cristina Sarbulescu, Victor Voicu
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.