Abstract: This disclosure concerns release mechanisms for medical implants, particularly embolic coils and the like, which utilize bulbous elements and receiving elements to constrain the bulbous elements. In some cases, the receiving elements are sized and shaped to help constrain the bulbous element axially and/or radially, and may work in concert with constraining elements and/or release wires that are optionally moveable independently of the receiving elements.

Abstract: Described here are devices, methods, and kits for the deployment of tissue anchors. In some variations, the devices may comprise a shaft defining a lumen for housing at least one anchor therein and a mechanism for deploying the anchor distally from the lumen. In certain variations, the devices may comprise one or more stop elements. For example, a device may comprise a stop element that limits the advancement of the device through an opening in a wall portion or at the distal end of another device.

Abstract: An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.

Abstract: Multilayer structures including a porous layer and a non-porous layer are useful as buttresses when associated with a surgical stapling apparatus.

Abstract: Embolic implants delivery systems and methods of manufacture and delivery are disclosed. The devices can be used for aneurysm and/or fistula treatment. The designs offer low profile compressibility for delivery to neurovasculature, while maintaining advantageous delivery and implant detachment control features.

Abstract: Devices, systems, and methods for performing an ophthalmic procedure in an eye are disclosed. The devices include a hand-held portion and a distal, elongate member coupled to the hand-held portion having a lumen operatively coupled to a vacuum source. A drive mechanism operatively coupled to the elongate member is configured to oscillate the elongate member. When in use, the device is configured to aspirate ocular material from the eye through the lumen. The drive mechanism retracts the elongate member with a retraction speed profile and advances the elongate member with an extension speed profile. The retraction speed profile is different from the extension speed profile.

Abstract: A method of diverting fluid flow from a first vessel including an occlusion to a second vessel includes deploying a prosthesis at least partially in a fistula and making valves in the second vessel incompetent. Making the valves in the second vessel incompetent includes at least one of using a reverse valvulotome to cut the valves, inflating a balloon, expanding a stent, and lining the second vessel with a stent.

Abstract: Medical device loading apparatuses, systems, methods and kits are described. A loading apparatus comprises a main body having a proximal end defining a proximal opening, a distal end defining a distal opening, and a passageway extending between the proximal and distal openings. The passageway defines a proximal chamber having a first inner diameter, a distal chamber having a second inner diameter, and a transition chamber disposed between the proximal and distal chambers. The transition chamber has an inner diameter that transitions from the larger second inner diameter to the smaller first inner diameter. The main body has a separable connection that divides the main body between proximal and distal portions when disrupted.

Abstract: An insertion instrument is configured to eject at least one anchor body into respective target locations, and subsequently apply a predetermined tensile force at least one actuation member of the at least one anchor member so as to actuate the at least one anchor body from a first configuration to a second expanded configuration. The insertion instrument can include a tension assembly that applies the predetermined tensile force to the at least one actuation member. The predetermined tensile force can be defined by a distance of travel, a predetermined failure force of a fuse, or a combination of distance of travel and a predetermined failure force of a fuse.

Abstract: A device and method is provided to gain access to interior body regions. The system includes a safety needle assembly, a stylet assembly, a blade assembly, an obturator assembly, and a dilator assembly. The safety needle assembly or stylet assembly accesses an interior body region, after which the blade assembly expands the pathway created by the safety needle assembly or stylet assembly. The obturator then further expands the pathway and delivers the dilator assembly to the desired location. The safety needle assembly, obturator assembly, and blade assembly are removed, leaving the dilator assembly in place for future procedures.

Abstract: A device for reducing the volume of a hollow body organ includes a tissue port and a plurality of fasteners. The fasteners may be coupled to a flexible filament, such as a suture, which is tensioned to constrict the hollow body organ to achieve volume reduction.

Abstract: An endograft introducer assembly having a transfer sheath is disclosed. The assembly includes a pusher assembly comprising a guide wire catheter, a tip mounted to a proximal end of the guide wire catheter, a stent graft receiving portion distal of the tip and a pusher distal of the receiving portion. The assembly further includes a transfer sheath extending distally over the stent graft receiving portion from a proximal position adjacent to the tip, the transfer sheath having a first length over the stent graft receiving portion; and a stopper disposed co-axially around the transfer sheath. The stopper has a proximal end terminating in a stopper surface and a distal portion, the distal portion removably engaged with the transfer sheath so as to prevent relative axial movement between the stopper and the transfer sheath in at least one direction.

Abstract: A substantially U-shaped staple has a bridge, legs, and an internally disposed compression device with a bias portion having a compression surface movably disposed between the legs and a compression resistor connected to the bridge and to the compression surface and is formed to resist movement of the compression surface towards the bridge with a force.

Abstract: A compression device, useful for applying circumferential compression to an object, includes a simplified cinch mechanism. The device includes a guidance slide, a jamming feature/pull tab, a buckle assembly and a cinch strap, which form a loop for placing about an object. The cinch strap includes both an inner portion, anchored to the jamming feature, and an outer portion, anchored to the guidance slide. The inner portion of the cinch strap passes through the guidance slide to an adjustable, locking side of the buckle assembly, and the outer portion of the cinch strap passes from the adjustable, locking side of the buckle assembly to the guidance slide. The cinch strap can move freely when pulled on by the inner portion and lock when pulled on by the outer portion, such that an inner circumference of the device is adjustable but can maintain a minimum circumferential length after tension is applied.

Abstract: A polymeric surgical ligating clip is provided having curved leg members joined by a resilient hinge. A leg member includes a flexible rib protruding from a vessel clamping inner surface and extends longitudinally between the proximal and distal end portions of the leg member. The flexible rib defines a channel extending transversely through the rib along a majority of said length. The flexible rib can collapse and provides better retention of the clip on a vessel. The clip can contain a flexible rib on both legs in an interlocking fashion. Or a plurality of teeth can protrude from a second vessel clamping inner surface of a second leg member. The plurality of teeth can include first and second rows of teeth extending longitudinally on the second leg member, transversely separated from each other on opposite sides of a centerline of the clip.

Abstract: In one aspect, the present invention provides a device for occluding an aperture in a body, for example, a patent foramen ovale (PFO), including a first side adapted to be disposed on one side of the septum and a second side adapted to be disposed on the opposite side of the septum. The device has an elongated, low-profile delivery configuration and a shortened, radially expanded deployment configuration. The first and second sides are adapted to occlude the aperture upon deployment of the device at its intended delivery location. The device also includes a radially expandable center portion. In some embodiments, the center portion includes a plurality of ribs provided by slits in device. The ribs expand radially when the device is deployed. The expandable center portion facilitates the positioning of the device in the aperture. The device can be secured in the deployed configuration using a catch system.

Abstract: An intraluminal scoring system for expanding an opening within an intraluminal passage includes a balloon catheter which is positioned alongside plaque lining a wall of the intraluminal passage. A wire is positioned between the balloon and the plaque so that the inflation of the balloon restricts the wire between the balloon and the plaque. After the balloon is inflated, a mechanical vibration is induced in the proximal end of the wire by a lithotripter actuator. The vibration travels through the wire to the distal portion, causing the wire to impact the plaque lining the wall of the passage causing scoring, compression, or fragmentation of the plaque.

Abstract: Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measurable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

Abstract: A surgical device for temporary protection of an anastomosis in the colon, the rectum, or the anal passage, including: a semi-rigid hollow longitudinal temporary anchor element, a first wall of which includes a substantially cylindrical main portion with a substantially circular section having a length of at least 50 mm, the first wall having an outside diameter that may be varied in a controlled manner; and a flexible sheath fixed to the anchor element against, preferably around, the first wall and having a length downstream of the anchor element of at least 50 cm, and an outside diameter when at rest in the range 20 mm to 40 mm, and the sheath is made from a biocompatible elastomer material having a wall thickness in the range 0.05 mm to 1 mm.

Abstract: An assembly and method for the protection of medical personnel from accidental suture needle sticks is described. The assembly includes a case containing a needle which can be retracted when not in use. The needle is extended and retracted through the engagement of a needle driver which compresses a compressible member. The compressible member exerts a force on the needle which in turn extends the needle's point beyond the casing so that the user can suture tissue. Disengaging the needle driver retracts the needle point which protects the user from accidentally receiving a needle prick from a contaminated needle between punctures.