Patents Examined by Christine J. Saoud
  • Corticotropin-releasing hormone analogs and their uses
    Patent number: 7285534
    Abstract: This invention provides members of the corticiotropin-releasing hormone superfamily and peptide analogs thereof wherein the 38th amino acid from the N-terminus is D-Nle, i.e. [D-Nle38]-CRH peptide. The peptide analogs can be used to treat proliferative disorders of the skin such as melanoma.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: October 23, 2007
    Assignee: The Regents of the University of California
    Inventors: Edward Wei, Kurt Carlson
  • PRO4356 antibodies
    Patent number: 7285645
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: October 23, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • PRO 4326 polypeptides
    Patent number: 7282560
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: October 16, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • PRO1508 antibodies
    Patent number: 7282569
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: October 16, 2007
    Assignee: Genetech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • Steroid hormone binding protein
    Patent number: 7279284
    Abstract: Several ESTs deduced as a part of a cDNA encoding a protein that is homologous with a membrane-bound steroid binding protein PMBP were found. Based on the sequence data of these ESTs, a consensus sequence was extracted, and primers were designed based on this consensus sequence. Using the thus designed primers, a polymerase chain reaction of human genes was effected. As a result, a gene encoding a novel steroid hormone binding protein that is homologous with PMBP was successfully isolated from a human for the first time.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: October 9, 2007
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventor: Yuichi Hirata
  • VEGF inhibitor polypeptides
    Patent number: 7279159
    Abstract: Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: October 9, 2007
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Thomas J. Daly, James P. Fandl, Nicholas J. Papadopoulos
  • Pro1782 polypeptides
    Patent number: 7279552
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: October 9, 2007
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Maureen Beresini, Laura DeForge, Luc Desnoyers, Ellen Filvaroff, Wei-Qiang Gao, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Steven Sherwood, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Methods of treating a tumor that expresses APRIL by administering BCMA
    Patent number: 7276241
    Abstract: A novel receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: October 2, 2007
    Assignees: Biogen Idec MA Inc., Apoxis SA
    Inventors: Pascal Schneider, Jeffrey Thompson, Teresa Cachero, Christine Ambrose, Paul Rennert
  • Antibodies to a polypeptide encoded by a nucleic acid under-expressed in stomach and lung tumor
    Patent number: 7276586
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: October 2, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • PRO1757 antibodies
    Patent number: 7271250
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: September 18, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • ACPL antibodies and methods of use thereof
    Patent number: 7270817
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: September 18, 2007
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • Modified growth hormone
    Patent number: 7271150
    Abstract: The invention provides a growth hormone (GH) in which amino acids within the regulated secretory pathway (RSP) sorting signal have been mutated as well as a GH in which the three-dimensional conformation of the RSP sorting signal has been altered, and a composition comprising an effective amount of such a GH in an excipient.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: September 18, 2007
    Assignee: United States of America, Represented by the Secretary, Department of Health and Human Services
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce J. Baum, Christopher R. Snell
  • Ligand of G protein-coupled receptor protein and DNA thereof
    Patent number: 7268212
    Abstract: A GPR7 ligand containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:1 wherein the N-terminal amino acid residue may optionally be brominated, is useful in developing a receptor-binding assay system with the use of the GPR7 expression system, in screening a candidate compound for a drug such as an antiobestic, etc.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: September 11, 2007
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Shuji Hinuma, Ryo Fujii, Shoji Fukusumi, Masaaki Mori, Hiromi Yoshida
  • IFN receptor 1 binding proteins, DNA encoding them, and methods of modulating cellular response to interferons
    Patent number: 7264945
    Abstract: Novel proteins IR1B1 and IR1B4 have been isolated which bind to the type I IFN receptor IFNAR1 and function in the cellular response to IFNs. DNA encoding such proteins in either the sense or anti-sense orientation can be administered to either enhance or inhibit the cellular response to IFNs. Antibodies to the proteins can be used for isolation of the new protein or for immunodetection thereof.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: September 4, 2007
    Assignee: Yeda Research and Development Co. Ltd
    Inventors: Michel Revel, Carolina Abramovitch, Judith E. Chebath
  • Methods for treating neuropathic pain by administering IL-10 polypeptides
    Patent number: 7261882
    Abstract: Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: August 28, 2007
    Assignee: Reagents of the University of Colorado
    Inventor: Linda May Rothblum Watkins
  • Method for the treatment of multiple sclerosis
    Patent number: 7258859
    Abstract: A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to the subject a therapeutically effective amount of an IL-21 receptor antagonist, wherein the subject has failed to respond treatment with beta interferon, thereby treating the subject.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: August 21, 2007
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Roland Martin, Henry McFarland, Bibiana Bielekova
  • Methods for diagnosing and treatment of hyperphosphatemic conditions using FGF20 polypeptides
    Patent number: 7259144
    Abstract: The present invention describes novel methods for diagnosis and treatment of conditions that alter phosphate transport in mammals. The fibroblast growth factor proteins and nucleotides that may be useful as a therapeutic or in the diagnosis of such conditions are also described.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: August 21, 2007
    Assignee: CuraGen Corporation
    Inventor: Richard A. Shimkets
  • Polypeptide encoded by a nucleic acid under-expressed in stomach and lung tumor
    Patent number: 7259238
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: August 21, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • Rage-related methods for treating inflammation
    Patent number: 7258857
    Abstract: The present invention provides a method for treating inflammation in a subject which comprises administering to the subject soluble receptor for advanced glycation endproduct (sRAGE) in an amount effective to inhibit binding of advanced glycation endproducts (AGEs) to RAGE thereby treating inflammation in the subject. The present invention also provides for a method for treating inflammation in a subject which comprises administering to the subject an agent in an amount effective to inhibit the interaction between receptor for advanced glycation endproduct (RAGE) and its ligand thereby treating inflammation in the subject.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 21, 2007
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: David M. Stern, Kevan Herold, Shi Du Yan, Ann Marie Schmidt, Ira Lamster
  • Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
    Patent number: 7255860
    Abstract: The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: August 14, 2007
    Assignee: Rinat Neuroscience Corp.
    Inventors: David L. Shelton, German J. Vergara