Patents Examined by Christine T Mui
  • System and method for providing stable fluid flow
    Patent number: 11156543
    Abstract: An embodiment of a system with a minute measure of pulsatility in a flow of a fluid is described that comprises a first pump configured to flow the fluid to a junction at a first flow rate that comprises a measure of pulsatility; and a second pump configured to flow a portion of the fluid from the junction at a second flow rate that is less than the first flow rate to produce a flow of the fluid at a third flow rate from the junction with a minute measure of pulsatility.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: October 26, 2021
    Assignee: Life Technologies Corporation
    Inventors: Michael Ward, Jason Malkin
  • Fluidic device for the detection, capture, or removal of a disease material
    Patent number: 11154861
    Abstract: The present disclosure relates to a fluidic device to detect, capture, and/or remove disease material in a biological fluid. The present invention also relates to methods for the treatment/prevention of sepsis through the use of the claimed device.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: October 26, 2021
    Assignee: Vanderbilt University
    Inventors: Sinead E. Miller, Charleson S. Bell, Todd D. Giorgio, Andrew L. Cook
  • Sensor assembly for a sample fluid analysis system
    Patent number: 11154859
    Abstract: A sensor assembly includes a first sensor substrate with upper surface, lower surface opposite upper surface, and a first set of sensors on the first sensor substrate. The sensor assembly includes a second sensor substrate with upper surface, lower surface in opposite upper surface, and a second set of sensors on the second sensor substrate. The sensor assembly includes a base with upper surface, lower surface opposite upper surface of the base along a vertical direction, a front end, a rear end opposite the front end along a longitudinal direction perpendicular to the vertical direction, a first recess at least partially holds the first sensor substrate, a second recess at least partially holds the second sensor substrate, a first fluid passage for receiving a fluid, and a second fluid passage in series with and open to the first fluid passage. Both sensors are exposed to its corresponding fluid passage.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: October 26, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Christian Pudduck
  • Additive channels
    Patent number: 11150255
    Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: October 19, 2021
    Assignee: EMULATE, Inc.
    Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoungshin Park, Antonio Varone, Andries Van der Meer, Monicah Otieno, David Conegliano
  • Cartridge and method of distributing biological sample in fluid channel thereof
    Patent number: 11141726
    Abstract: A cartridge includes a plate including a fluid inlet and a fluid outlet, a biochip disposed under the plate, and a first adhesive layer bonding the plate and the biochip. A fluid channel is formed between the plate and the biochip. The fluid inlet and the fluid outlet are in fluid communication with the fluid channel.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: October 12, 2021
    Assignee: LifeOS Genomics Corporation
    Inventors: Cheng-Chang Lai, Hung-Wen Chang, Timothy Z. Liu, Ching-Jou Huang
  • Device for safe storing and expelling of a liquid solution
    Patent number: 11141139
    Abstract: A device for safe storing and expelling of a liquid solution, including: an annular body having a proximal portion and a distal portion and including a transverse member connected along its circumference to an inner lateral surface of the annular body between the proximal portion and the distal portion of the annular body; and a liquid tight piston fitting tightly and movable within the proximal portion of the annular body, wherein the piston includes one or more longitudinal members longitudinally protruding from the piston into an interior of the proximal portion of the annular body, and wherein each of the one or more longitudinal members includes a sharp end to cut the transverse member of the annular body when the one or more longitudinal members being pushed against the transverse member of the annular body.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: October 12, 2021
    Assignee: AID GENOMICS LTD
    Inventors: Snir Zano, Itzhak Mintz
  • Membrane-coated sintered porous media for sample collection
    Patent number: 11141951
    Abstract: The present application provides devices and methods of making and using these devices. The devices comprise a sintered porous polymeric material, a porous membrane attached to at least a portion of the sintered porous polymeric material, and optionally a housing which surrounds at least a portion of the sintered porous polymeric material. The devices can be used for sample collection, purification and transfer.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: October 12, 2021
    Assignee: Porex Corporation
    Inventors: Guoqiang Mao, Kyle Thomas Harris, Katlin Marie Lumme, Jeffrey John Williams
  • Cantilever sensors for molecule detection
    Patent number: 11137392
    Abstract: A method of preparing a cantilever sensor for measuring biochemical interactions and their associated stress wherein a cantilever having two sides is coated on one side with at least a gold layer and both sides of the cantilever are functionalized with a self-assembled monolayer (SAM) of a probe molecule by incubating the cantilever in a solution having a concentration of the probe molecule of between 1 to 1000 ?M. The unpassivated cantilever sensor comprising a layer coated on one side with a coating comprising gold and being unpassivated on the opposite side, wherein both surfaces comprises a self-assembled monolayer of a probe molecule in which the surface area occupied per probe molecule varies in the range 0.4-1.5 nm2, enabling the stress at the gold top surface that is not cancelled out by a counter stress from the bottom surface so that accurate quantitation of a target molecule is achieved.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: October 5, 2021
    Assignee: 3P SENSE LIMITED
    Inventors: Joseph Wafula Ndieyira, Samadhan Patil, Giuseppe Mazza, Massimo Pinzani
  • Interlocking cap and vial
    Patent number: 11136617
    Abstract: A cap that is securable to a vial includes a plug configured for insertion into an open end of the vial. An upper portion of the cap defines a probe recess with an open top end and configured to receive a distal end of a probe of a pipettor inserted into the open top end, to frictionally secure the cap to an end of the probe. The cap includes a radially-oriented annular surface with one or more locking members depending from a periphery of the annular surface. The locking members are spaced from the plug and each locking member includes a radial locking groove and a radial locking ridge beneath the radial locking groove. A lip of the vial snaps into the radial locking groove above the radial locking ridge to secure the cap to the vial when the plug is inserted into the open end of the vial.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: October 5, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Byron J. Knight, David A. Buse, Norbert D. Hagen, David Opalsky, Tyler Moore, Anita Prasad, Bruce Richardson
  • Method of identifying or evaluating synergistic combinations of actives and compositions containing the same
    Patent number: 11137387
    Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 5, 2021
    Assignee: The Procter & Gamble Company
    Inventors: John Erich Oblong, Holly Ann Rovito
  • Check valves for microfluidic systems and methods thereof
    Patent number: 11130129
    Abstract: The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: September 28, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Cameron Scott Ball, Ronald F. Renzi, Robert Meagher
  • Pipette tip container
    Patent number: 11130122
    Abstract: A pipette tip container comprising a pipette tip having a lumen extending between a proximal opening of a first diameter and a distal orifice of a second smaller diameter; a pellet arranged in the lumen of the pipette tip between said proximal opening and distal orifice, the second diameter being too narrow to let the pellet pass; and a retainer arranged between the pellet and the proximal opening and arranged to prevent the pellet from moving past the retainer in the lumen but to let fluid move past the retainer in the lumen; the retainer having a distal end such that a portion of its periphery does not contact the inner wall of the lumen, a proximal end such that a portion of its periphery maintains the retainer in the lumen by friction with the inner wall of the lumen; and a radial opening between the distal and proximal ends.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: September 28, 2021
    Assignee: Bio-Rad Europe GmbH
    Inventors: Typhaine Dagland, Gilles Venturi, Vincent Doury, Laurent Fournier
  • Measuring device with injector and spray deflector
    Patent number: 11131632
    Abstract: A measuring device for the measurement of light signals emitted from samples in wells of a microplate, in particular to a luminescence measuring device for measuring luminescence signals. The luminescence measuring device has a first injector with an injector needle having an outlet end for dispensing a reagent into a well, and a luminescence optical device having an optical axis extending substantially perpendicularly to the microplate and a measuring region surrounding the optical axis. The injector needle extends to below the luminescence optical device and opens with its outlet end into the measuring region. The luminescence measuring device has further a spray deflector arranged between the outlet end of the injector and the luminescence optical device.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 28, 2021
    Assignee: TECAN TRADING AG
    Inventors: Manfred Lansing, Johannes Posch, Tobias Sawetzki
  • Systems and methods for performing biological assays
    Patent number: 11123736
    Abstract: Systems and methods for performing biological assays are provided herein. The systems and methods determine one or more characteristics of a nucleic acid amplification sample based on a modified optical property of the sample.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: September 21, 2021
    Assignee: Lucira Health, Inc.
    Inventors: Debkishore Mitra, Frank B. Myers, III, John Robert Waldeisen, Ivan Krastev Dimov
  • Automated diagnostic analyzers having rear accessible track systems and related methods
    Patent number: 11125766
    Abstract: Example apparatus and methods related to automated diagnostic analyzers having rear accessible track systems are described herein. An example apparatus disclosed herein includes an analyzer to perform a diagnostic test. The analyzer has a first side and a second side opposite the first side. The example apparatus includes a loading bay disposed on the first side of the analyzer to receive a first carrier and a pipetting mechanism coupled to the analyzer adjacent the second side. The example apparatus also includes a first carrier shuttle to transport the first carrier from a first location adjacent the loading bay to a second location adjacent the pipetting mechanism and a track disposed adjacent the second side of the analyzer to transfer a second carrier to a third location adjacent the pipetting mechanism.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: September 21, 2021
    Assignees: Abbott Laboratories, Canon Medical Systems Corporation
    Inventors: Brian L. Ochranek, David C. Arnquist, Takehiko Oonuma, Hirotoshi Tahara, Naoto Sato, Bradley P. Smith
  • Methods, devices, and systems for analyte detection and analysis
    Patent number: 11118223
    Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: September 14, 2021
    Assignee: ULTIMA GENOMICS, INC.
    Inventors: Gilad Almogy, Nathan Beckett, Stephanie Kubecka
  • Non-poissonian droplet partitioning using feedback
    Patent number: 11117134
    Abstract: A method of partitioning droplets from a fluid reservoir containing particles provides a non-Poissonian distribution of dispensed droplets containing a desired number of particles.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: September 14, 2021
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Laura Huang, Benjamin James Hadwen, Adam Christopher Wilson
  • Non-hydrogen-bonding universal reader for DNA sequencing
    Patent number: 11119089
    Abstract: The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: September 14, 2021
    Assignee: Arizona Board of Regents on behalf of Arizona
    Inventors: Peiming Zhang, Sovan Biswas, Suman Sen, Stuart Lindsay
  • Systems and methods for multi-analysis
    Patent number: 11112418
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: September 7, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Daniel Young, Samartha Anekal, Chinmay Pangarkar
  • Microfluidic structure, microfluidic device having the same and method of controlling the microfluidic device
    Patent number: 11110454
    Abstract: A microfluidic structure in which a plurality of chambers arranged at different positions are connected in parallel and into which a fixed amount of fluid may be efficiently distributed without using a separate driving source, and a microfluidic device having the same. The microfluidic device includes a platform having a center of rotation and including at least one microfluidic structure. The microfluidic structure includes a sample supply chamber configured to accommodate a sample, a plurality of first chambers arranged in a circumferential direction of the platform at different distances from the center of rotation of the platform, and a plurality of siphon channels, each of the siphon channels being connected to a corresponding one of the first chambers.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: September 7, 2021
    Assignee: NEXUS DX, INC.
    Inventor: Beom Seok Lee