Patents Examined by Christohpher R. Tate
  • Cyclic nucleotide phosphodiesterase and a method for production thereof
    Patent number: 5728563
    Abstract: A novel cyclic nucleotide phosphodiesterase, which is different from known isozyme families, is isolated and purified from rat cerebrum. This enzyme has the following physicochemical properties (1) to (3). (1) The enzyme acts on cAMP to form 5'-AMP and on cGMP to form 5'-GMP; (2) The Km values for cAMP and cGMP are 0.11 .mu.M and 1.78 .mu.M, respectively, as indicating substrate specificity; and (3) the molecular weight is approximately 298000.
    Type: Grant
    Filed: June 21, 1995
    Date of Patent: March 17, 1998
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventor: Toshio Tanaka