Abstract: A therapeutic effect assessment system, including: a probe shaped and sized to be inserted into a brain of a subject, having a proximal end and a distal end and a longitudinal axis, the probe including a plurality of contacts operably coupled thereto, disposed along the longitudinal axis, wherein the probe is selectively operable for stimulating an electrophysiological evoked responses; at least one electrode configured to record readings of evoked responses caused by the stimulating; and an analysis module electrically connected to the probe and to the at least one electrode, wherein the analysis module is configured to transform or reduce certain parameters from the recorded readings of evoked responses in order to identify a threshold of brain stimulation that produces a therapeutic effect.

Abstract: Various fixation techniques for implantable medical device (IMDs) are described. In one example, an assembly comprises an IMD; and a set of active fixation tines attached to the IMD. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the IMD to a hooked position in which the active fixation tines bend back towards the IMD. The active fixation tines are configured to secure the IMD to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.

Abstract: Described herein is an apparatus and method for predicting Pulsed Field Ablation (PFA) durability. An apparatus may include at least a processor; and a memory communicatively connected to the at least processor, wherein the memory contains instructions configuring the at least processor to receive a training dataset comprising a plurality of example PFA device parameters correlated to a plurality of example PFA outcomes; train a PFA durability machine learning model using the training dataset; receive a PFA device parameter; and generate a PFA durability datum as a function of the PFA device parameter using a trained PFA durability machine learning model.

Abstract: Various fixation techniques for implantable medical device (IMDs) are described. In one example, an assembly comprises an IMD; and a set of active fixation tines attached to the IMD. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the IMD to a hooked position in which the active fixation tines bend back towards the IMD. The active fixation tines are configured to secure the IMD to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

Abstract: A method for treating sleep disordered breathing includes electrically stimulating an upper airway patency-related nerve via implantable stimulation elements.

Abstract: A non-invasive, wearable and portable medical device for evaluation and monitoring the heart condition for patients with congestive heart failure and a CHF management system is provided comprising a wearable textile-based device utilizing physiologic and biometric sensors, a Signal Acquisition Unit, and a monitoring system executing a suite of software algorithms to monitor and evaluate patients with CHF.

Abstract: A method is described, which provides electrical stimulation to a person, where the current flows from a subcranial electrode, through a target brain region, through a separate conductive path, and back to a subcutaneous electrode, and where the parameters of the electric current pulses are set to influence the resonant properties of the brain.

Abstract: An automated method of controlling neural stimulation. A neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway, and the stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable such as observed ECAP voltage (V) is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value for a future stimulus. The method adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway. A compensating transfer function is applied to the feedback variable, the compensating transfer function being configured to compensate for both (i) a distance-dependent transfer function of stimulation, and (ii) a distance dependent transfer function of measurement which is distinct from (i).

Abstract: An external power source, implantable medical device, and method for indicating an extent of power transfer between an external coil to an internal coil associated with the implantable medical device. According to one aspect, a method includes determining a parameter that depends on an extent to which the external coil is aligned with the internal coil, where the parameter includes at least one of an indication of an internal coil output power and power transfer efficiency and a resonant frequency of the external coil when inductively coupled to the internal coil. The method further includes indicating an extent to which the external coil is aligned with the internal coil based on the parameter.

Abstract: The present specification describes methods and systems for monitoring changes in physiological data, such as electrocardiogram data, respiration data, and blood pressure data, as a consequence of a change in position or movement of a subject under observation. Embodiments of the present specification provide systems for detecting and processing motion data by utilizing an available physiological monitoring device, with minimal additions of cost and equipment. A connecting wire is used to add a motion sensor to an existing physiological monitoring device. The connecting wire provides a channel for powering the motion sensing device as well as communication of data to and from the motion sensing device. Preferably, the motion sensor is embedded into the wire.

Abstract: An electrosurgical probe with internal cooling for use in systems and methods for lesioning in bone and other tissue is disclosed. The probe includes a distal electrical insulator, a proximal electrical insulator, a distal electrical conductor defining a distal electrode with a closed distal end and a proximal electrical conductor defining a proximal electrode, the distal electrode longitudinally spaced apart and electrically isolated from the proximal electrode by the distal electrical insulator. The distal electrode has a closed proximal end formed by a distal face of the distal electrical insulator to thereby define a closed distal inner lumen for circulating the cooling fluid. The proximal electrode has a closed distal end formed by a proximal face of the distal electrical insulator and a closed proximal end formed by a distal face of the proximal electrical insulator to thereby define a closed proximal inner lumen for circulating the cooling fluid.

Abstract: In one embodiment, a method for fabricating a neurostimulation stimulation lead comprises: providing a plurality of ring components and hypotubes in a mold; placing an annular frame with multiple lumens over distal ends of the plurality of hypotubes to position a portion of each hypotube within a respective lumen of the annular frame; molding the plurality of ring components and the hypotubes to form a stimulation tip component for the stimulation lead, wherein the molding fills interstitial spaces between the plurality of ring components and hypotubes with insulative material; and forming segmented electrodes from the ring components after performing the molding.

Abstract: A cortical stimulating and recording electrode includes a flexible support element for a conductive element, the flexible support element having a head end and a tail end. The conductive element has a head contact and a tail contact, arranged respectively at the head end and tail end of the flexible support element, such that the conductive element transmits signals from the head contact to the tail contact and vice versa. Moreover, the conductive element is configured as a conductive track formed of a layer of conductive ink deposited on the flexible support element.

Abstract: It has been discovered that pain felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. A method has been developed to reduce pain in a painful region following limb joint replacement by stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following total knee arthroplasty surgery or other limb joint replacement surgeries.

Abstract: An electrode guide device is described for inserting a cochlear implant electrode array into a scala tympany of a patient cochlea has an electrode guide tube and an end positioner at least partially contained within a cavity of the guide tube at the distal end and slidable within the cavity for adjustable extension beyond the distal end. The end positioner has a natural curvature that is constrained by the cavity of the guide tube for any portion contained within the cavity of the guide tube, and any portion of the end positioner extended beyond the distal end follows the natural curvature. The electrode array can be introduced through the groove of the guide tube along a first directional line towards an electrode opening in the patient cochlea, and then the distal end of electrode array emerging from the guide tube is redirected by the extension of the end positioner along a different second directional line through the electrode opening.

Abstract: A connector assembly includes a base and a detachable cover. Ports on separate sidewalls receive an extension cable and a lead. A blade assembly maintains electrical contact between the cable and the lead, while providing a surface to strip insulation and/or sever the lead. Further, the blade is resilient so as to maintain sufficient contact with the lead when the cover is attached and/or locked to the base.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices, systems, and methods for controlled volume ablation of tissue. In one example, a catheter may include an elongated member having a distal end extending along a longitudinal axis. A first electrode may extend along the elongated member. The first electrode may have a distal portion arranged on a circumferential surface about the longitudinal axis at the distal end. A second electrode may extend along the elongated member. The second electrode may have a distal portion arranged on the circumferential surface about the longitudinal axis at the distal end of the elongated member. A sheath may be slidably disposed about the elongated member. The sheath may be configured to change position by sliding along the member to insulate a portion of one or both of the first and second electrode.

Abstract: The disclosed physiological feedback systems and methods assist with assessing, monitoring and/or treating a patient experiencing a cardiac arrest event. The systems and methods receive multiple inputs and are continuous and/or iterative during a treatment session to provide physiological state trends of the patient. An index of the physiological state of the patient can be derived and confounders, and/or their effects, can be identified, and/or removed, from the index. Additionally, the systems and methods can assist with determining ischemic injury in a patient based on cerebral tissue oxygenation and/or other physiological data.

Abstract: Surgical robotic systems including synchronous and asynchronous networks and methods employing the same are provided. One surgical robotic system includes a networked computing node, a slave robot assembly, and first and second communication paths. The slave robot assembly includes subunits, communicatively coupled to one another by way of the first communication paths, thereby forming at least a portion of a synchronous network. The networked computing node and a subunit are communicatively coupled to one another by way of the second communication paths, thereby forming at least a portion of a second network, and are configured to communicate one or more packets to one another by way of the second network. The subunit is configured to communicate, with the other subunits via the synchronous network, data from the one or more packets. A clock rate of the synchronous network is independent from a clock rate of the second network.