Abstract: An ophthalmological apparatus comprises a laser source for producing a pulsed laser beam, a scanner system for deflecting the pulsed laser beam at a treatment speed in the eye tissue along a scanning treatment line, a first scanning apparatus connected upstream of the scanner system for deflecting the pulsed laser beam and for producing a first scanning movement component superposed on the scanning treatment line in a first scanning direction at a first scanning speed that is higher as compared to the treatment speed, and a second scanning apparatus connected upstream of the scanner system for deflecting the pulsed laser beam and for producing a second scanning movement component, which is superposed on the first scanning movement component in a second scanning direction, which is at an angle to the first scanning direction, at a second scanning speed that is higher as compared to the first scanning speed.

Abstract: There is provided a deep brain stimulation system having k focuses, which comprises: a first electrode and a second electrode, used for connecting one side of a brain scalp; a third electrode and a fourth electrode, used for connecting the other side of the brain scalp; and a first signal generation unit, a second signal generation unit, . . . , a (2k?1)th signal generation unit and a 2kth signal generation unit, wherein the k is a positive integer greater than or equal to 2; and each of the signal generation units is used for providing the following currents for the first electrode to the fourth electrode: a first current and a second current, which are interfered at a deep portion of a brain to form a first focus; and a (2k?1)th current and a 2kth current, which are interfered at the deep portion of the brain to form a kth focus.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.

Abstract: In one embodiment, a method for fabricating a neurostimulation stimulation lead comprises: providing a plurality of ring components and hypotubes in a mold; placing an annular frame with multiple lumens over distal ends of the plurality of hypotubes to position a portion of each hypotube within a respective lumen of the annular frame; molding the plurality of ring components and the hypotubes to form a stimulation tip component for the stimulation lead, wherein the molding fills interstitial spaces between the plurality of ring components and hypotubes with insulative material; and forming segmented electrodes from the ring components after performing the molding.

Abstract: A method of detecting a subject's physiological status, seizure state, or seizure type with limb-based accelerometers identifying a favored accelerometer or limb that provides a better sensitivity or false positive rate as compared to other accelerometers or limbs. The detection method may include determining whether the seizure conforms with an anticipated seizure type, and determining whether to base a seizure detection on data from the favored or un-favored accelerometers or limbs. The method may also include applying a weighing factor to base the detection on data obtained primarily from the favored accelerometer or limb or to not rely on data obtained primarily from un-favored accelerometers or limbs. The method may also include comparing data obtained from a favored accelerometer or limb with data obtained from other accelerometers or limbs or obtained from detection devices using ECG or EEG. An alert may be generated based on the detection of a seizure.

Abstract: A method for treating neurological pain includes inserting an introducer needle of gauge 18 or smaller through a percutaneous incision site on a body, coupling a first mating feature at a distal end of an elongate member of a stylet to a second mating feature of an implantable device that is configured to receive a wireless signal and to generate one or more electrical pulses from the wireless signal for exciting a tissue within the body, advancing the stylet and the implantable device together as an assembly to the tissue within the body through a lumen of the introducer needle, and applying the one or more electrical pulses to one or more electrodes of the implantable device to modulate the tissue within the body.

Abstract: Systems and methods for treatment of a spine of a patient. The system includes a treatment device comprising a probe tip at a distal end of the device. The system further includes a display device configured to display information associated with the treatment. The system further includes at least one computing device in electrical communication with the display device and the treatment device. The memory of the computing device includes software for operating a GUI. The at least one computing device configured to display the GUI comprising a virtual representation of: a first skeletal structure; at least one of an organ and a muscle; and a nerve network. The device also configured to display a graphic along a portion of the neural pathways associated with a user selected vertebra of the vertebrae when the treatment device is actuated to deliver the treatment.

Abstract: A method includes receiving an electrocardiogram (ECG) measured at a given location over a portion of a heart. Based on the measured ECG, a rhythmic pattern is identified over a given time-interval. The rhythmic pattern corresponds to a relation between a present cardiac cycle length and a preceding cardiac cycle length. Based on the identified rhythmic pattern, a classification of the location as either showing regular pattern or showing arrhythmia is determined. The location is graphically encoded according to the classification. The graphically encoded location is overlaid on an anatomical map of the portion of a heart.

Abstract: We report a method of a method for detecting an epileptic seizure, comprising providing a first body signal reference value; determining a current body signal value from a time series of body signals; comparing the current body signal value and the first reference value; determining a work level of the patient; determining whether the current body signal value comprises an ictal component, based on the work level and the comparing; issuing a detection of an epileptic seizure in response to the determination that the current body signal value comprises the ictal component; and taking at least one further action (e.g. warning, delivering a therapy, etc.), based on the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

Abstract: A neural stimulation system comprises a microphone arrangement for capturing an audio signal from ambient sound, a sound processor unit, a headpiece, and an implantable neural stimulator, the sound processor unit comprising a housing to be worn behind a patient's ear or at a patient's body, and a signal processing unit within the sound processor unit housing for generating a neural stimulation signal from the captured audio signal, the sound processor being communicatively coupled to the headpiece for supplying the neural stimulation signal to the headpiece, the headpiece comprising a housing separate from the housing of the sound processor and to be fixed at the patient's head, a signal transmission unit for transmitting the neural stimulation signal to a signal receiving unit of the implantable cochlear stimulator, and a user interface for controlling operation of the sound processor unit.

Abstract: The devices and method described herein allow for therapeutic damage to increase volume in these hyperdynamic hearts to allow improved physiology and ventricular filling and to reduce diastolic filling pressure by making the ventricle less stiff. For example, improving a diastolic heart function in a heart by creating at least one incision in cardiac muscle forming an interior heart wall of the interior chamber where the at least one incision extends into one or more layers of the interior heart wall without puncturing through the interior heart wall and the incision is sufficient to reduce a stiffness of the interior chamber to increase volume of the chamber and reduce diastolic filling pressure.

Abstract: The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.

Abstract: The invention relates to a method for obtaining brain wave data using a microelectrode array, comprising a plurality of electrodes for electrically measuring brain waves and an integrated optical stimulation unit for stimulating brain regions by means of optical signals, wherein the stimulation unit has one or more electrical light sources, and wherein the method includes stimulating neurons of the brain via optical signals produced by the light sources, recording a response of the neurons to the stimulation via the electrodes, unambiguously assigning the recorded response to individual optical stimulation signals provided by the light source, and determining an unambiguous correlation between the optical stimulation signals and resulting brain waves measured by the electrodes.

Abstract: A non-invasive, wearable and portable medical device for evaluation and monitoring the heart condition for patients with congestive heart failure and a CHF management system is provided comprising a wearable textile-based device utilizing physiologic and biometric sensors, a Signal Acquisition Unit, and a monitoring system executing a suite of software algorithms to monitor and evaluate patients with CHF.

Abstract: Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface.

Abstract: There is provided a neurostimulator and method for delivering to a subject a stimulation in response to a predicted or detected condition. The neurostimulator including: a power circuit for providing electrical power to the neurostimulator; a recording array having a plurality of electrodes for recording a plurality of neurophysiological signals corresponding to a plurality of sites of the subject; a signal processor configured to: determine a phase synchrony among the neurophysiological signals; and associate selected phase synchrony calculations with the prediction or detection of a neurological or neurophysiological condition; and one or more stimulators for delivering to the subject a stimulation in response to the predicted or detected condition.

Abstract: A magnetic resonance imaging (MRI) telemetry arrangement and process for a cochlear implant system are described. Electrode current is measured that is induced in a cochlear implant electrode lead during an MRI process performed on an implanted patient. An MRI telemetry signal for an external telemetry sensor is then output based on the measured electrode current.

Abstract: A method and apparatus for hemodynamically characterizing a neurological or fitness state by dynamic scattering light (DLS) is disclosed herein. In particular, a non-pulsatile blood-shear-rate-descriptive (BSRD) signal(s) is optically generated and analyzed. In some embodiments, the BSRD signal is generated dynamically so as to adaptively maximize (i.e. according to a bandpass or frequency-selection profile) a prominence of a predetermined non-pulsatile physiological signal within the BSRD. In some embodiments, the BSRD is subjected to a stochastic or stationary-status analysis. Alternatively or additionally, the neurological or fitness state may be computed from multiple BSRDs, including two or more of: (i) a [sub-200 Hz, ˜300 Hz] BSRD signal; (ii) a [˜300 Hz, ˜1000 Hz] signal; (iii) a [˜1000 Hz, ˜4000 Hz] signal and (iv) a [˜4000 Hz, z Hz] (z>=7,000) signal.

Abstract: A medical device lead assembly includes an end connector element having a plurality of fixed connection element tabs each respectively extending from the end connector element to a tab distal end, and a lead body having a plurality of lead filars extending through the lead body and forming a filar coil. Each of the plurality of lead filars is coupled to a corresponding fixed connection tab. Each of the plurality of lead filars have a diameter of less than 150 micrometers or less than 125 micrometers, or from 50 to 125 micrometers or from 50 to 100 micrometers. The filar coil having an outer diameter value being less than 1.5 mm and a first pitch within the lead body and a second pitch adjacent to the end connector element and the second pitch is greater than the first pitch.

Abstract: The disclosed physiological feedback systems and methods assist with assessing, monitoring and/or treating a patient experiencing a cardiac arrest event. The systems and methods receive multiple inputs and are continuous and/or iterative during a treatment session to provide physiological state trends of the patient. An index of the physiological state of the patient can be derived and confounders, and/or their effects, can be identified, and/or removed, from the index. Additionally, the systems and methods can assist with determining ischemic injury in a patient based on cerebral tissue oxygenation and/or other physiological data.