Patents Examined by Christopher S. F. Low
  • Methods for removing suspended particles from soluble protein solutions
    Patent number: 6995246
    Abstract: The present invention provides soluble protein solutions, free of suspended particles in high yield. More particularly, the current invention provides a method for removing suspended particles from soluble protein solutions by filtering the soluble protein solution through highly purified diatomaceous earth.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: February 7, 2006
    Assignee: Akzo Nobel N.V.
    Inventors: Min Wan, Susan M Rabideau
  • Method for the treatment of incontinence
    Patent number: 6992109
    Abstract: The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid to treat incontinence.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: January 31, 2006
    Inventors: Catherine A. Segal, Leslie Magnus
  • Anti-tumor composition
    Patent number: 6992106
    Abstract: The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus methods of cancer and tumor treatment using the composition are also provided.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: January 31, 2006
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshihiro Morinaga, Yukio Nihei, Yasuyo Suga, Manabu Suzuki, Kazuo Ohishi, Akira Okano
  • Solution composition of an oxazolidinone antibiotic drug having enhanced drug loading
    Patent number: 6989381
    Abstract: There is provided a pharmaceutical composition for therapeutic or prophylactic administration to a subject having an infective disease or condition or at risk thereof. The composition comprises an aqueous carrier having in solution therein (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug in solution at such a drug concentration. The composition is particularly useful for intravenous delivery of the drug.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: January 24, 2006
    Assignee: Pharmacia Corporation
    Inventor: Sandra M. Sims
  • Exendins, exendin agonists, and methods for their use
    Patent number: 6989366
    Abstract: Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: January 24, 2006
    Assignee: Amylin PHarmaceuticals, Inc.
    Inventors: Nigel Robert Arnold Beeley, Kathryn S. Prickett, Sunil Bhavsar
  • P53 inhibitors and therapeutic use of the same
    Patent number: 6982277
    Abstract: The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: January 3, 2006
    Assignee: The Board of Trutees of the University of Illinois
    Inventors: Andrei V. Gudkov, Pavel G. Komarov, Elena A. Komarova
  • Method for inhibition of angiogenesis and vasculogenesis
    Patent number: 6977271
    Abstract: The present invention provides a method for inhibiting or preventing angiogenesis in animals and humans comprising the steps of administering to the animal or human an effective amount of one or more isomers of conjugated linoleic acid (“CLA”). The CLA may be administered in the form of a free fatty acid, an ester, or as a salt, in a pill, or as a component of a natural or prepared food product.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: December 20, 2005
    Assignee: Health Research, Inc.
    Inventors: Margot M. Ip, Patricia Masso-Welch, Clement Ip, Danilo Zangani
  • Hemoglobin-antioxidant conjugates
    Patent number: 6974794
    Abstract: There are provided biocompatible chemical compositions having oxygen transporting capability and comprising oxygen transporting molecules chemically bound to antioxidants, to form compositions capable of protecting a mammalian body from oxidative damage. An example of a composition according to the invention is hemoglobin covalently coupled to a 6-hydroxy chroman carboxylic acid, such as Trolox.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: December 13, 2005
    Assignee: Hemosol LP
    Inventors: James Gordon Adamson, Greg Angus McIntosh
  • Method for reducing food intake
    Patent number: 6972291
    Abstract: Provided is a method for curbing dietary cravings in a patient, typically a diabetic or obese patient, by administration of a low dose of naltrexone to the patient.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: December 6, 2005
    Inventor: Richard K. Bernstein
  • Topical spray compositions
    Patent number: 6962691
    Abstract: A topical, medicinal spray composition is provided comprising a drug or combination of drugs in a carrier which, when sprayed on a surface, forms a film. The composition comprises at least one medicament, at least one film former and at least one vehicle. The composition of the invention may further comprise at least one permeation enhancer, at least one solubilizer, at least one plasticizer, and at least one water soluble additive. A metered dose of the composition can be sprayed on a topical site to form a stable, breathable film, preferably over a fixed surface area. A wide range of medicaments for human and veterinary use may be present that act locally or transdermally.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: November 8, 2005
    Assignee: U & I Pharmaceuticals Ltd.
    Inventors: Amar Lulla, Geena Malhotra, Preeti Raut
  • Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
    Patent number: 6962979
    Abstract: The present invention discloses novel crosslinked biomaterial compsotions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bix(sulfosuccinimidyl) suberate, and dithiobis(succinimidylpropionate). Crosslinked biomaterial compositions prepared using mixtures of hydrophobic and hydrophilic crosslinking agents are also disclosed. The compositions of the present invention can be used to prepare formed implants for use in a variety of medical applications.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: November 8, 2005
    Assignee: Cohesion Technologies, Inc.
    Inventor: Woonza M. Rhee
  • Dental and oralogic composition
    Patent number: 6951463
    Abstract: The first embodiment of present invention provides a composition, which includes: (a) a photocatalytic titanium oxide or a photocatalytic titanium oxide precursor; (b) at least one selected from the group including: a silicon compound having the following formula (I): wherein X1, X2, X3 and X4 each independently represent an alkoxy group or a halogen atom, a hydrolyzate of the silicon compound (I), a silicone resin, silicone resin precursor and silica; and (c) a liquid medium. Another embodiment of the present invention provides a dental and oralogic composition, that includes a photocatalytic titanium oxide or a photocatalytic titanium oxide precursor. Another embodiment of the present invention provides a dental and oralogic composition, that includes a photocatalytic titanium oxide or a photocatalytic titanium oxide precursor, and a liquid medium.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: October 4, 2005
    Assignee: Kuraray Co., Ltd.
    Inventors: Eiichi Masuhara, Yoshinori Kadoma, Junichi Yamauchi, Koichi Okada, Satoshi Yamaguchi
  • Use of serotonin agents for adjunct therapy in the treatment of cancer
    Patent number: 6927223
    Abstract: The invention provides a method for the treatment of cancer comprising administering a serotonin agent. Also provided is a method for the treatment of cachexia comprising administering a serotonin agent.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: August 9, 2005
    Assignee: Washington State University Research Foundation
    Inventors: Gary G. Meadows, Tanja Obradovic
  • Compounds with growth hormone releasing properties
    Patent number: 6919315
    Abstract: Disclosed are compounds of formula I formula I wherein R1, R2, R5, R6, R7, R8, G, J, L, M, a, b, c, d, e, and f are as defined in the specification, and compositions containing them. These compounds are useful for treating medical disorders resulting from a deficiency in growth hormone.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: July 19, 2005
    Assignee: Novo Nordisk A/S
    Inventors: Bernd Peschke, Birgit Richter, Thomas Hansen Kruse, Michael Ankersen, Lutz Richter
  • Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
    Patent number: 6914122
    Abstract: The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: July 5, 2005
    Assignee: Schering Corporation
    Inventors: Srikanth Venkatraman, Kevin X. Chen, Ashok Arasappan, F. George Njoroge, Viyyoor Moopil Girijavallabhan, Ashit K. Ganguly, Tin-Yau Chan, Brian Alexander Mc Kittrick, Nanhua Hugh Yao, Andrew Joseph Prongay, Vincent Stewart Madison
  • Antipicornaviral compounds, their preparation and use
    Patent number: 6906198
    Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: June 14, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr., Jayashree Girish Tikhe
  • Aqueous ifosfamide composition
    Patent number: 6906047
    Abstract: This invention is directed towards a ready-to-use aqueous composition of ifosfamide. In one embodiment, the invention is directed to an aqueous ifosfamide composition which comprises ifosfamide, a pharmaceutically acceptable buffer, and water. The concentration of ifosfamide in the composition may be between about 40 mM and about 400 mM. The concentration of buffer in the composition may be between about 10 mM and about 260 mM. The molar ratio of ifosfamide to buffer may be between about 0.5:1 to about 20:1. The pH of the composition may be between about 4 and about 8.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: June 14, 2005
    Assignee: Gensia Sicor Pharmaceuticals, Inc.
    Inventors: Dorla Mirejovsky, Michael Burkhart
  • Cartilage/bone inducing materials for reparation
    Patent number: 6903071
    Abstract: A cartrilage and bone morphogenetic repairing composition comprising a collagen-free aqueous solution of a polyoxyethylene-polyoxypropylene and an effective amount of a bone morphogenetic protein, the molecular weight of polyoxypropylene as a constituent of said polyoxyethylene-polyoxypropylene molecular is 900 to 4,000 in a unit of Dalton (D) and the ethylene oxide content is 5 to 90% by weight of the polyoxyethylene-propoxypropylene molecule whereby the solution is liquid at 1 to 30° C. and gelatinizes at about 37° C. and a method of using the same.
    Type: Grant
    Filed: November 14, 1996
    Date of Patent: June 7, 2005
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Takesada Shimura, Satsuki Toriyama
  • Phosphoramidates and methods therefor
    Patent number: 6903081
    Abstract: Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosphate esters or amides. Described phosphoramidate compounds exhibit antiproliferative activity. Pharmaceutical formulations are provided for treatment of cancers.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: June 7, 2005
    Assignee: Purdue Research Foundation
    Inventors: Richard F. Borch, Hugo Garrido-Hernandez, Sandra C. Tobias
  • Benzimidazole compounds, and pharmaceutical compositions and unit dosages thereof
    Patent number: 6900235
    Abstract: Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: May 31, 2005
    Assignee: UAF Technologies and Research, LLC
    Inventors: Joseph K. Agyin, James C. Quada, Jr., James Berger Camden