Abstract: A sensor (1) for detection of gas, in particular for detection of CO2. The sensor (1) has a contact face (2) which is directed towards a measuring site. The sensor (1) includes at least one radiation source (3), a measurement volume (4) for receiving the gas to be measured, and at least a first detector (5) for detection of radiation transmitted from the source (3) to the first detector (5) through the measurement volume (4). The sensor has a path (6) of the radiation between radiation source (3) and first detector (5). The radiation propagates along the path in a non-imaging way.

Abstract: Disclosed herein are devices and methods for detecting blood glucose levels in a subject that involve passively quantifying mid-infrared emissions from the eye of the subject.

Abstract: The present invention provides for the use of hydroxyapatite-selective fluorescent dyes in combination with fluorescence lifetime imaging to detect any hydroxyapatite spherules or hydroxyapatite deposits in the retina tissue of a subject, including the peripheral or macula tissue, wherein the hydroxyapatite spherules or hydroxyapatite deposits initiate or support the growth of sub-RPE deposits and correlates with age-related macular degeneration and/or Alzheimer's disease.

Abstract: A method and system for adjusting the AUC limit threshold to reduce the number of false alarms. In one embodiment the method includes the steps of: defining a AUC limit threshold; defining a saturation limit threshold for a desired oxygen saturation level; periodically measuring a patient's measured oxygen saturation level over time; calculating the difference between the patient's measured oxygen saturation and defined saturation limit threshold; summing the differences between the patient's measured oxygen saturation and defined saturation limit threshold over a time interval wherein the patient's measured oxygen saturation is less than defined saturation limit threshold, wherein the summation defines a measured AUC; comparing the measured AUC over the time interval against the defined AUC limit threshold; determining regions in which the measured AUC exceeds the defined AUC limit threshold; and adjusting the AUC limit threshold.

Abstract: A non-invasive optical internal substance detector includes: a diode array including a plurality of light emitting diodes (LEDs) for emitting light toward a target where an internal substance is detected, and a plurality of photodiodes (PDs) for receiving light which is reflected from the target after being emitted from the plurality of light emitting diodes; and a controller for controlling the plurality of light emitting diodes to be turned on or off and for processing a signal obtained from the photodiodes. The plurality of light emitting diodes and the plurality of photodiodes each have a size of several micrometers to several tens of micrometers and are arranged at intervals of several micrometers to several tens of micrometers from each other.

Abstract: An analyte monitoring system may include one or more of an analyte sensor, a transceiver, a display device, and a management system. The transceiver may be configured to receive sensor data from the analyte sensor and calculate analyte monitoring information. The display device may be configured to receive the analyte monitoring information from the transceiver. The management system may be configured to receive analyte monitoring information from the display device. The management system may be configured to use the analyte monitoring information to produce a comparison result. The management system may be configured to, based on the comparison result, transmit to the display device management information associated with the received analyte monitoring information. Producing the comparison result may include comparing one or more performance diagnostics with one or more performance indicators. Producing the comparison result may include comparing compliance information with usage protocol information.

Abstract: A measurement system for measuring blood characteristics includes a controller, an emitter, a sensor, and a reference sensor. The emitter emits light at a plurality of wavelengths from a first side of a blood flow channel to a second side of the blood flow channel. The sensor is provided on the second side of the blood flow channel. The reference sensor is provided on the first side of the blood flow channel. The controller compensates measurements from the sensor based upon measurements from the reference sensor. The reference sensor may be disposed in a position to increase noise immunity of the measurement system. The measurement system may be connected to or part of a dialysis system.

Abstract: An infrared light source radiates infrared light. An ATR prism receives, on a first end face, the infrared light radiated from the infrared light source, causes the received infrared light to pass therethrough while repeating total reflection off a second end face and a third end face, and emits the infrared light that has passed therethrough from the third end face. An infrared photodetector detects the intensity of the infrared light emitted from the ATR prism. Strain sensors, which are contact sensors of one type, are attached to the ATR prism and configured to detect a contact state between the ATR prism and a measurement skin.

Abstract: A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values.

Abstract: An endoscope system includes an endoscope with an image pickup that generates image data by capturing an image of tissue illuminated with light containing wavelength regions spaced from and not overlapping with each other. The image pickup has an RGB filter, the wavelength regions include first and second regions corresponding to a B region and to a G region of the filter. A processor calculates an index representing a molar concentration ratio of first and second biological substances contained in the tissue based on the image data including information on the first and second regions. In the first region, image data B of the tissue varies depending on the molar concentration ratio, the second region contains isosbestic points of the tissue, and, in the second region, image data G has a constant value. The processor calculates the index based on the data B and G.

Abstract: An embodiment of the present disclosure seeks to select characteristics of incoming intensity data that cause comparisons of selected characteristics to produce defined probe off space having reduced crossover with defined probe on space. Once defined, the present disclosure compares characteristics of incoming intensity data with the now defined probe off space, and in some embodiments, defined probe on space, to determine whether a probe off condition exists. When a processor determines a probe off condition exists, the processor may output or trigger an output signal that audibly and/or visually indicates to a user that the optical sensor should be adjusted for a proper application to a measurement site.

Abstract: A pulse oximeter may reduce power consumption in the absence of overriding conditions. Various sampling mechanisms may be used individually or in combination. Various parameters may be monitored to trigger or override a reduced power consumption state. In this manner, a pulse oximeter can lower power consumption without sacrificing performance during, for example, high noise conditions or oxygen desaturations.

Abstract: The present disclosure provides a system and method for analyzing a physiological parameter of a vital sign signal. The method may include acquiring a vital sign signal, storing data, computing and analyzing, processing, and outputting a result. The system may compute and analyze the physiological parameter of the vital sign signal, especially a blood oxygen saturation, via a plurality of algorithms, judge or process the computation result, and output the judgment result.

Abstract: A measurement apparatus for measuring biological information includes a sensor that executes selectively at least a first detection mode or a second detection mode, and a controller. The controller controls switching to the second detection mode based on output of the sensor while the sensor is in the first detection mode.

Abstract: A method is provided for predicting that a patient will require a blood transfusion during a treatment. The method includes obtaining, on a processor, first data that indicates values for one or more parameters of a characteristic of a continuous photoplethysmographic (PPG) waveform collected during the treatment. The method further includes applying, on the processor, coefficients to the values for the one or more parameters. The method further includes determining, on the processor, second data that indicates a prediction that the patient will require the blood transfusion during the treatment based on applying the coefficients to the values for the one or more parameters. An apparatus is also provided for predicting that the patient will require the blood transfusion during the treatment.

Abstract: A system and method for continuous glucose monitoring (CGM) of blood in a blood vessel of a patient using a non-invasive sensor composed of a patch antenna operating in the Industrial, Scientific and Medical (ISM) Radio band (5.725 GHz-5.875 GHz). The device determines the blood glucose concentration of the blood in the blood vessel based on the measured shift of the resonant frequency of the non-invasive antenna patch sensor. A radio frequency (RF) synthesizer is used to drive the patch antenna with a fraction of its output coupled to both the antenna and receiver through a directional coupler. In this approach both the transmitted (FWD) and received (REV) power are processed, by demodulating logarithmic amplifiers, which convert the RF signals to corresponding voltages for downstream processing. The resulting voltages are then fed into a microcontroller and the measured shift in resonant frequency is converted to a real-time glucose concentration.

Abstract: A monitoring device configured to be attached to a subject includes a sensor configured to detect and/or measure physiological information and a processor coupled to the sensor. The sensor includes at least one optical emitter and at least one optical detector. The processor receives and analyzes signals produced by the sensor, and the processor changes wavelength of light emitted by the at least one optical emitter in response to detecting a change in subject activity. For example, the processor instructs the at least one optical emitter to emit shorter wavelength light in response to detecting an increase in subject activity, and the processor instructs the at least one optical emitter to emit longer wavelength light in response to detecting an decrease in subject activity. Detecting a change in subject activity may include detecting a change in at least one subject vital sign and/or subject motion.

Abstract: A sensor device includes a first light emitter that emits light with a wavelength from a first spectral range, a second light emitter that emits light with a wavelength from a second spectral range, a first light detector configured to detect light with a wavelength from the first spectral range, but not to respond to light with a wavelength from the second spectral range, and a second light detector configured to detect light with a wavelength from the first spectral range and light with a wavelength from the second spectral range, wherein a distance between the first light emitter and the first light detector is smaller than a distance between the second light emitter and the second light detector.

Abstract: A monitoring device configured to be attached to a subject includes a photoplethysmography (PPG) sensor configured to measure a plurality of physiological parameters from the subject, a motion sensor configured to detect an activity state of the subject, and a processor coupled to the PPG sensor and the motion sensor. The PPG sensor is configured to measure each physiological parameter in a respective one of a plurality of time intervals. The processor instructs the PPG sensor to measure a first one of the plurality of physiological parameters if the activity state is at or above a threshold, and to measure a second one of the plurality of physiological parameters if the activity state is below the threshold.

Abstract: A system includes a sensor, a second connector, a local processor, a first telemetry module, a second telemetry module, and a remote processor. The sensor is coupled to a cord and the cord has a first connector. The second connector is coupled to a housing. The second connector is configured to mate with the first connector. The local processor is coupled to the second connector and disposed in the housing. The local processor is configured to execute instructions stored in a local memory. The local memory is disposed in the housing. The local processor is configured to generate calculated data based on a signal received at the second connector. The signal corresponds to a parameter measured by the sensor. The first telemetry module is coupled to the local processor and is configured to wirelessly communicate the calculated data. The second telemetry module is configured to communicate with the first telemetry module. The remote processor is coupled to the second telemetry module.