Patents Examined by Chukwuma Nwaonivha
  • Pharmaceutically active pyrrolidine derivatives as Bax inhibitors
    Patent number: 7018988
    Abstract: The present invention is related to new substituted pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention of neurodegenerative disorders, diseases associated with polygultamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders renal hypoxia, hepatitis and AIDS. Said pyrrolidine derivatives display a modulatory and most notably a down-regulating-up to an inhibitory-activity with respect to the cellular death agonist Bax and/or the activation pathways leading to Bax and allows therefore to block the release of cytochrome (c).
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: March 28, 2006
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Serge Halazy, Anna Quattropani, Agnes Bombrun, Mattias Schwarz, Russel Thomas, Anthony Baxter
  • Syntheses of quinazolinones
    Patent number: 7009049
    Abstract: The present invention is directed to methods for the preparation of enantiomerically pure quinazolinones, intermediates in such methods, and compositions comprising such quinazolinones.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: March 7, 2006
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Gustave Bergnes, Edward Ha, George Yiannikouros, Panos Kalaritis, Brandon E. Yonce, Kurt Alan Welday, Jr.